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Protein

Histone-lysine N-methyltransferase

Gene

Smp_055310

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei327S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
ORF Names:Smp_055310Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
Proteomesi
  • UP000008854 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi6183.Smp_055310__mRNA.

Structurei

3D structure databases

ProteinModelPortaliG4V5N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini272 – 394SETInterPro annotationAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni282 – 284S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni354 – 355S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1085. Eukaryota.
COG2940. LUCA.
InParanoidiG4V5N4.
OMAiRERENNF.
OrthoDBiEOG091G0UBI.
PhylomeDBiG4V5N4.

Family and domain databases

InterProiView protein in InterPro
IPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

G4V5N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSVKVSSHS YTLKWEDSSS IENSYSKKHC LHSCNSSSPS LRQTQLNFSP
60 70 80 90 100
NHQTKLSKQF ENVVDVIKPN NTNWSTNEKD SLKSNEHNSY PQTSIKPEPL
110 120 130 140 150
SVLLTESSNK SPESIITSPT RIMKQAILTE TGISPGGNVC KKPIRKKKAA
160 170 180 190 200
TNKKSQVKRS RSVDSPQINT ITKNDIDGND SVTLSTSNTR QTGTTTTTTR
210 220 230 240 250
VCKSTSVSPK KNSHVASDLC TATRNKQNKS KTQLQTQLTS YGIRKTARQY
260 270 280 290 300
AKEIEREREN NFLNALKNNI ETGMKIIQTE EKGRGIIATR TFYEGEFVVE
310 320 330 340 350
YAGDLISEKL AKQREAVYKQ NPEIGSYMFF FVHAGQRYCV DATKETPRLG
360 370 380 390 400
RLINHSRLKP NCIVKVIPID GIPRLALFAR KSISPGEELL YDYGDRDKET

LQLHPWLKT
Length:409
Mass (Da):46,039
Last modified:December 14, 2011 - v1
Checksum:i17662DB15B3678C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601624 Genomic DNA. Translation: CCD76627.1.
RefSeqiXP_018649498.1. XM_018795158.1.

Genome annotation databases

EnsemblMetazoaiSmp_055310.1; Smp_055310.1:pep; Smp_055310.
GeneDBiSmp_055310.1:pep.
GeneIDi8354950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HE601624 Genomic DNA. Translation: CCD76627.1.
RefSeqiXP_018649498.1. XM_018795158.1.

3D structure databases

ProteinModelPortaliG4V5N4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_055310__mRNA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_055310.1; Smp_055310.1:pep; Smp_055310.
GeneDBiSmp_055310.1:pep.
GeneIDi8354950.

Phylogenomic databases

eggNOGiKOG1085. Eukaryota.
COG2940. LUCA.
InParanoidiG4V5N4.
OMAiRERENNF.
OrthoDBiEOG091G0UBI.
PhylomeDBiG4V5N4.

Family and domain databases

InterProiView protein in InterPro
IPR016858. Hist_H4-K20_MeTrfase.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00856. SET. 1 hit.
SMARTiView protein in SMART
SM00317. SET. 1 hit.
PROSITEiView protein in PROSITE
PS51571. SAM_MT43_PR_SET. 1 hit.
PS50280. SET. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiG4V5N4_SCHMA
AccessioniPrimary (citable) accession number: G4V5N4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 15, 2017
This is version 32 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.