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G4RN83

- G4RN83_THETK

UniProt

G4RN83 - G4RN83_THETK

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Protein

Thymidine kinase

Gene

tdk

Organism
Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei84 – 841Proton acceptorUniRule annotation
Metal bindingi139 – 1391ZincUniRule annotation
Metal bindingi142 – 1421ZincUniRule annotation
Metal bindingi170 – 1701ZincUniRule annotation
Metal bindingi173 – 1731ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 148ATPUniRule annotation
Nucleotide bindingi83 – 864ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciTTEN768679:GJSY-357-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:TTX_0352Imported
OrganismiThermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)Imported
Taxonomic identifieri768679 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
ProteomesiUP000002654: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.
OMAiDHISEST.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

G4RN83-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVAIVGPMF AGKTTELIRL VERQVIAGRR AIVFKPTIDD RYDPDAVAAH
60 70 80 90 100
NGAKYKAVRV APDESGVGAI KELSASYQVV AVDEVQFFPP SLAEVLNELA
110 120 130 140 150
DEKLVVAAGL NLDYRGQPFE TTMRIMAYAD KVVSLTAVCT VCGRPATRTQ
160 170
RLAPGPRIYV GGAGLYEARC RRHHSVPG
Length:178
Mass (Da):19,254
Last modified:December 14, 2011 - v1
Checksum:i05FCDA3A8AF985B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN869859 Genomic DNA. Translation: CCC81027.1.
RefSeqiWP_014126284.1. NC_016070.1.
YP_004892107.1. NC_016070.1.

Genome annotation databases

EnsemblBacteriaiCCC81027; CCC81027; TTX_0352.
GeneIDi11263362.
KEGGittn:TTX_0352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN869859 Genomic DNA. Translation: CCC81027.1 .
RefSeqi WP_014126284.1. NC_016070.1.
YP_004892107.1. NC_016070.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC81027 ; CCC81027 ; TTX_0352 .
GeneIDi 11263362.
KEGGi ttn:TTX_0352.

Phylogenomic databases

KOi K00857.
OMAi DHISEST.

Enzyme and pathway databases

BioCyci TTEN768679:GJSY-357-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1Imported.

Entry informationi

Entry nameiG4RN83_THETK
AccessioniPrimary (citable) accession number: G4RN83
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 29, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3