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Protein

Thymidine kinase

Gene

tdk

Organism
Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84Proton acceptorUniRule annotation1
Metal bindingi139ZincUniRule annotation1
Metal bindingi142ZincUniRule annotation1
Metal bindingi170ZincUniRule annotation1
Metal bindingi173ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 14ATPUniRule annotation8
Nucleotide bindingi83 – 86ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciTTEN768679:G1H3R-369-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:TTX_0352Imported
OrganismiThermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)Imported
Taxonomic identifieri768679 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
Proteomesi
  • UP000002654 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi768679.TTX_0352

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04798 Archaea
COG1435 LUCA
KOiK00857
OMAiKEQFGWI

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

G4RN83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVAIVGPMF AGKTTELIRL VERQVIAGRR AIVFKPTIDD RYDPDAVAAH
60 70 80 90 100
NGAKYKAVRV APDESGVGAI KELSASYQVV AVDEVQFFPP SLAEVLNELA
110 120 130 140 150
DEKLVVAAGL NLDYRGQPFE TTMRIMAYAD KVVSLTAVCT VCGRPATRTQ
160 170
RLAPGPRIYV GGAGLYEARC RRHHSVPG
Length:178
Mass (Da):19,254
Last modified:December 14, 2011 - v1
Checksum:i05FCDA3A8AF985B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN869859 Genomic DNA Translation: CCC81027.1
RefSeqiWP_014126284.1, NC_016070.1

Genome annotation databases

EnsemblBacteriaiCCC81027; CCC81027; TTX_0352
GeneIDi11263362
KEGGittn:TTX_0352
PATRICifig|768679.9.peg.369

Similar proteinsi

Entry informationi

Entry nameiG4RN83_THETK
AccessioniPrimary (citable) accession number: G4RN83
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: February 28, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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