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G4RLQ5

- G4RLQ5_THETK

UniProt

G4RLQ5 - G4RLQ5_THETK

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Protein

DNA ligase

Gene

lig1

Organism
Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Note: Divalent metal cations.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531ATPUniRule annotation
Active sitei255 – 2551N6-AMP-lysine intermediateUniRule annotation
Binding sitei260 – 2601ATPUniRule annotation
Binding sitei275 – 2751ATPUniRule annotation
Binding sitei305 – 3051ATPUniRule annotation
Binding sitei345 – 3451ATPUniRule annotation
Binding sitei420 – 4201ATPUniRule annotation
Binding sitei426 – 4261ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA biosynthetic process Source: InterPro
  4. DNA ligation involved in DNA repair Source: InterPro
  5. DNA recombination Source: UniProtKB-HAMAP
  6. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTEN768679:GJSY-1865-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:lig1Imported
Synonyms:ligUniRule annotationImported
Ordered Locus Names:TTX_1883Imported
OrganismiThermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)Imported
Taxonomic identifieri768679 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
ProteomesiUP000002654: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG4RLQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4RLQ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEFSELAKVL AGIESTTQRT MMVKLLVNLF KKLGPDEIDK AIYIILGDVR
60 70 80 90 100
PPWEGVELGI AEKLCLRALS RASGVKLEEL ESLYQKTGDV GEAARKALSK
110 120 130 140 150
RQAQTLLAFA GAKRAPLSIS QVYDTFLKIA RTTGEGSIDL KVSLLSSLFS
160 170 180 190 200
QASPEEAKYI ARFVVGKLRL GVADMTIIDA LAEAFNVDEG QLEKAYNIHP
210 220 230 240 250
DLGYLAKVVL ERGQAGLAQV RVTPGVPVMP MLAQRLSTSH EVLTKLGGAA
260 270 280 290 300
ICEYKYDGER AQIHIGPNGI SIYSRRLENI THAYPDVVEA VRRSVSAKEA
310 320 330 340 350
IIEGEIVALD PDTGDILPFQ ELMHRKRKHE VEEAMREYPV KLNLFDVIYL
360 370 380 390 400
DGEDLTDKPL IYRRLKLSEI VRESEDVVIA KWALFDDEEK VDLFFHEAIS
410 420 430 440 450
MGMEGLVCKS PTSLYEMGAR GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR
460 470 480 490 500
GKRAGLYGAF LMAAYDPKTD MFYTVCKVGS GFTDADLKKM YQMLEPYKID
510 520 530 540 550
HRHPRVSSRM EPDVWFTPGI VLEIIGAEIT LSPLHTCCQG AIKPDVGLAI
560 570 580 590
RFPRFTGRYR SDKGPEEATT VDELLEIYRN QKKVKLEGPA TT
Length:592
Mass (Da):66,176
Last modified:December 14, 2011 - v1
Checksum:i74C715A0BFBF00F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN869859 Genomic DNA. Translation: CCC82500.1.
RefSeqiWP_014127753.1. NC_016070.1.
YP_004893578.1. NC_016070.1.

Genome annotation databases

EnsemblBacteriaiCCC82500; CCC82500; TTX_1883.
GeneIDi11262769.
KEGGittn:TTX_1883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN869859 Genomic DNA. Translation: CCC82500.1 .
RefSeqi WP_014127753.1. NC_016070.1.
YP_004893578.1. NC_016070.1.

3D structure databases

ProteinModelPortali G4RLQ5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC82500 ; CCC82500 ; TTX_1883 .
GeneIDi 11262769.
KEGGi ttn:TTX_1883.

Phylogenomic databases

KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci TTEN768679:GJSY-1865-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1Imported.

Entry informationi

Entry nameiG4RLQ5_THETK
AccessioniPrimary (citable) accession number: G4RLQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 26, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3