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G4RLQ5 (G4RLQ5_THETK) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA ligase RuleBase RU000617 HAMAP-Rule MF_00407
EC=6.5.1.1 RuleBase RU000617 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig1 EMBL CCC82500.1
Synonyms:lig HAMAP-Rule MF_00407
Ordered Locus Names:TTX_1883 EMBL CCC82500.1
OrganismThermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) [Complete proteome] [HAMAP]
Taxonomic identifier768679 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Thermoproteus ›

Protein attributes

Sequence length592 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617 HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196 HAMAP-Rule MF_00407

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2551N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2531ATP By similarity HAMAP-Rule MF_00407
Binding site2601ATP By similarity HAMAP-Rule MF_00407
Binding site2751ATP By similarity HAMAP-Rule MF_00407
Binding site3051ATP By similarity HAMAP-Rule MF_00407
Binding site3451ATP By similarity HAMAP-Rule MF_00407
Binding site4201ATP By similarity HAMAP-Rule MF_00407
Binding site4261ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
G4RLQ5 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: 74C715A0BFBF00F9

FASTA59266,176
        10         20         30         40         50         60 
MEFSELAKVL AGIESTTQRT MMVKLLVNLF KKLGPDEIDK AIYIILGDVR PPWEGVELGI 

        70         80         90        100        110        120 
AEKLCLRALS RASGVKLEEL ESLYQKTGDV GEAARKALSK RQAQTLLAFA GAKRAPLSIS 

       130        140        150        160        170        180 
QVYDTFLKIA RTTGEGSIDL KVSLLSSLFS QASPEEAKYI ARFVVGKLRL GVADMTIIDA 

       190        200        210        220        230        240 
LAEAFNVDEG QLEKAYNIHP DLGYLAKVVL ERGQAGLAQV RVTPGVPVMP MLAQRLSTSH 

       250        260        270        280        290        300 
EVLTKLGGAA ICEYKYDGER AQIHIGPNGI SIYSRRLENI THAYPDVVEA VRRSVSAKEA 

       310        320        330        340        350        360 
IIEGEIVALD PDTGDILPFQ ELMHRKRKHE VEEAMREYPV KLNLFDVIYL DGEDLTDKPL 

       370        380        390        400        410        420 
IYRRLKLSEI VRESEDVVIA KWALFDDEEK VDLFFHEAIS MGMEGLVCKS PTSLYEMGAR 

       430        440        450        460        470        480 
GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR GKRAGLYGAF LMAAYDPKTD MFYTVCKVGS 

       490        500        510        520        530        540 
GFTDADLKKM YQMLEPYKID HRHPRVSSRM EPDVWFTPGI VLEIIGAEIT LSPLHTCCQG 

       550        560        570        580        590 
AIKPDVGLAI RFPRFTGRYR SDKGPEEATT VDELLEIYRN QKKVKLEGPA TT

« Hide

References

[1]"The complete genome sequence of Thermoproteus tenax: a physiologically versatile member of the Crenarchaeota."
Siebers B., Zaparty M., Raddatz G., Tjaden B., Albers S.V., Bell S.D., Blombach F., Kletzin A., Kyrpides N., Lanz C., Plagens A., Rampp M., Rosinus A., von Jan M., Makarova K.S., Klenk H.P., Schuster S.C., Hensel R.
PLoS ONE 6:E24222-E24222(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN869859 Genomic DNA. Translation: CCC82500.1.
RefSeqYP_004893578.1. NC_016070.1.

3D structure databases

ProteinModelPortalG4RLQ5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC82500; CCC82500; TTX_1883.
GeneID11262769.
KEGGttn:TTX_1883.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK10747.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG4RLQ5_THETK
AccessionPrimary (citable) accession number: G4RLQ5
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info