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Protein

DNA ligase

Gene

lig1

Organism
Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei253ATPUniRule annotation1
Active sitei255N6-AMP-lysine intermediateUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei275ATPUniRule annotation1
Binding sitei305ATPUniRule annotation1
Binding sitei345ATPUniRule annotation1
Binding sitei420ATPUniRule annotation1
Binding sitei426ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTEN768679:G1H3R-1907-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:lig1Imported
Synonyms:ligUniRule annotation
Ordered Locus Names:TTX_1883Imported
OrganismiThermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)Imported
Taxonomic identifieri768679 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
Proteomesi
  • UP000002654 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi768679.TTX_1883

Structurei

3D structure databases

ProteinModelPortaliG4RLQ5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini333 – 466DNA_LIGASE_A3InterPro annotationAdd BLAST134

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01347 Archaea
COG1793 LUCA
KOiK10747
OMAiWIKYKRD

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

G4RLQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFSELAKVL AGIESTTQRT MMVKLLVNLF KKLGPDEIDK AIYIILGDVR
60 70 80 90 100
PPWEGVELGI AEKLCLRALS RASGVKLEEL ESLYQKTGDV GEAARKALSK
110 120 130 140 150
RQAQTLLAFA GAKRAPLSIS QVYDTFLKIA RTTGEGSIDL KVSLLSSLFS
160 170 180 190 200
QASPEEAKYI ARFVVGKLRL GVADMTIIDA LAEAFNVDEG QLEKAYNIHP
210 220 230 240 250
DLGYLAKVVL ERGQAGLAQV RVTPGVPVMP MLAQRLSTSH EVLTKLGGAA
260 270 280 290 300
ICEYKYDGER AQIHIGPNGI SIYSRRLENI THAYPDVVEA VRRSVSAKEA
310 320 330 340 350
IIEGEIVALD PDTGDILPFQ ELMHRKRKHE VEEAMREYPV KLNLFDVIYL
360 370 380 390 400
DGEDLTDKPL IYRRLKLSEI VRESEDVVIA KWALFDDEEK VDLFFHEAIS
410 420 430 440 450
MGMEGLVCKS PTSLYEMGAR GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR
460 470 480 490 500
GKRAGLYGAF LMAAYDPKTD MFYTVCKVGS GFTDADLKKM YQMLEPYKID
510 520 530 540 550
HRHPRVSSRM EPDVWFTPGI VLEIIGAEIT LSPLHTCCQG AIKPDVGLAI
560 570 580 590
RFPRFTGRYR SDKGPEEATT VDELLEIYRN QKKVKLEGPA TT
Length:592
Mass (Da):66,176
Last modified:December 14, 2011 - v1
Checksum:i74C715A0BFBF00F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN869859 Genomic DNA Translation: CCC82500.1
RefSeqiWP_014127753.1, NC_016070.1

Genome annotation databases

EnsemblBacteriaiCCC82500; CCC82500; TTX_1883
GeneIDi11262769
KEGGittn:TTX_1883
PATRICifig|768679.9.peg.1908

Similar proteinsi

Entry informationi

Entry nameiG4RLQ5_THETK
AccessioniPrimary (citable) accession number: G4RLQ5
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health