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G4RLQ5

- G4RLQ5_THETK

UniProt

G4RLQ5 - G4RLQ5_THETK

Protein

DNA ligase

Gene

lig1

Organism
Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei253 – 2531ATPUniRule annotation
    Active sitei255 – 2551N6-AMP-lysine intermediateUniRule annotation
    Binding sitei260 – 2601ATPUniRule annotation
    Binding sitei275 – 2751ATPUniRule annotation
    Binding sitei305 – 3051ATPUniRule annotation
    Binding sitei345 – 3451ATPUniRule annotation
    Binding sitei420 – 4201ATPUniRule annotation
    Binding sitei426 – 4261ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciTTEN768679:GJSY-1865-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:lig1Imported
    Synonyms:ligUniRule annotationImported
    Ordered Locus Names:TTX_1883Imported
    OrganismiThermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)Imported
    Taxonomic identifieri768679 [NCBI]
    Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
    ProteomesiUP000002654: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliG4RLQ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK10747.
    OMAiMVKMLEG.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G4RLQ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFSELAKVL AGIESTTQRT MMVKLLVNLF KKLGPDEIDK AIYIILGDVR    50
    PPWEGVELGI AEKLCLRALS RASGVKLEEL ESLYQKTGDV GEAARKALSK 100
    RQAQTLLAFA GAKRAPLSIS QVYDTFLKIA RTTGEGSIDL KVSLLSSLFS 150
    QASPEEAKYI ARFVVGKLRL GVADMTIIDA LAEAFNVDEG QLEKAYNIHP 200
    DLGYLAKVVL ERGQAGLAQV RVTPGVPVMP MLAQRLSTSH EVLTKLGGAA 250
    ICEYKYDGER AQIHIGPNGI SIYSRRLENI THAYPDVVEA VRRSVSAKEA 300
    IIEGEIVALD PDTGDILPFQ ELMHRKRKHE VEEAMREYPV KLNLFDVIYL 350
    DGEDLTDKPL IYRRLKLSEI VRESEDVVIA KWALFDDEEK VDLFFHEAIS 400
    MGMEGLVCKS PTSLYEMGAR GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR 450
    GKRAGLYGAF LMAAYDPKTD MFYTVCKVGS GFTDADLKKM YQMLEPYKID 500
    HRHPRVSSRM EPDVWFTPGI VLEIIGAEIT LSPLHTCCQG AIKPDVGLAI 550
    RFPRFTGRYR SDKGPEEATT VDELLEIYRN QKKVKLEGPA TT 592
    Length:592
    Mass (Da):66,176
    Last modified:December 14, 2011 - v1
    Checksum:i74C715A0BFBF00F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN869859 Genomic DNA. Translation: CCC82500.1.
    RefSeqiYP_004893578.1. NC_016070.1.

    Genome annotation databases

    EnsemblBacteriaiCCC82500; CCC82500; TTX_1883.
    GeneIDi11262769.
    KEGGittn:TTX_1883.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FN869859 Genomic DNA. Translation: CCC82500.1 .
    RefSeqi YP_004893578.1. NC_016070.1.

    3D structure databases

    ProteinModelPortali G4RLQ5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CCC82500 ; CCC82500 ; TTX_1883 .
    GeneIDi 11262769.
    KEGGi ttn:TTX_1883.

    Phylogenomic databases

    KOi K10747.
    OMAi MVKMLEG.

    Enzyme and pathway databases

    BioCyci TTEN768679:GJSY-1865-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1Imported.

    Entry informationi

    Entry nameiG4RLQ5_THETK
    AccessioniPrimary (citable) accession number: G4RLQ5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3