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G4RLQ5

- G4RLQ5_THETK

UniProt

G4RLQ5 - G4RLQ5_THETK

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Protein
DNA ligase
Gene
lig1, lig, TTX_1883
Organism
Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei253 – 2531ATP By similarityUniRule annotation
Active sitei255 – 2551N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei260 – 2601ATP By similarityUniRule annotation
Binding sitei275 – 2751ATP By similarityUniRule annotation
Binding sitei305 – 3051ATP By similarityUniRule annotation
Binding sitei345 – 3451ATP By similarityUniRule annotation
Binding sitei420 – 4201ATP By similarityUniRule annotation
Binding sitei426 – 4261ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciTTEN768679:GJSY-1865-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:lig1Imported
Synonyms:ligUniRule annotationImported
Ordered Locus Names:TTX_1883Imported
OrganismiThermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1)Imported
Taxonomic identifieri768679 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiThermoprotealesThermoproteaceaeThermoproteus
ProteomesiUP000002654: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG4RLQ5.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

KOiK10747.
OMAiMVKMLEG.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4RLQ5-1 [UniParc]FASTAAdd to Basket

« Hide

MEFSELAKVL AGIESTTQRT MMVKLLVNLF KKLGPDEIDK AIYIILGDVR    50
PPWEGVELGI AEKLCLRALS RASGVKLEEL ESLYQKTGDV GEAARKALSK 100
RQAQTLLAFA GAKRAPLSIS QVYDTFLKIA RTTGEGSIDL KVSLLSSLFS 150
QASPEEAKYI ARFVVGKLRL GVADMTIIDA LAEAFNVDEG QLEKAYNIHP 200
DLGYLAKVVL ERGQAGLAQV RVTPGVPVMP MLAQRLSTSH EVLTKLGGAA 250
ICEYKYDGER AQIHIGPNGI SIYSRRLENI THAYPDVVEA VRRSVSAKEA 300
IIEGEIVALD PDTGDILPFQ ELMHRKRKHE VEEAMREYPV KLNLFDVIYL 350
DGEDLTDKPL IYRRLKLSEI VRESEDVVIA KWALFDDEEK VDLFFHEAIS 400
MGMEGLVCKS PTSLYEMGAR GWNWIKYKRD YRSEMSDTVD LVVVGAFYGR 450
GKRAGLYGAF LMAAYDPKTD MFYTVCKVGS GFTDADLKKM YQMLEPYKID 500
HRHPRVSSRM EPDVWFTPGI VLEIIGAEIT LSPLHTCCQG AIKPDVGLAI 550
RFPRFTGRYR SDKGPEEATT VDELLEIYRN QKKVKLEGPA TT 592
Length:592
Mass (Da):66,176
Last modified:December 14, 2011 - v1
Checksum:i74C715A0BFBF00F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN869859 Genomic DNA. Translation: CCC82500.1.
RefSeqiYP_004893578.1. NC_016070.1.

Genome annotation databases

EnsemblBacteriaiCCC82500; CCC82500; TTX_1883.
GeneIDi11262769.
KEGGittn:TTX_1883.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FN869859 Genomic DNA. Translation: CCC82500.1 .
RefSeqi YP_004893578.1. NC_016070.1.

3D structure databases

ProteinModelPortali G4RLQ5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CCC82500 ; CCC82500 ; TTX_1883 .
GeneIDi 11262769.
KEGGi ttn:TTX_1883.

Phylogenomic databases

KOi K10747.
OMAi MVKMLEG.

Enzyme and pathway databases

BioCyci TTEN768679:GJSY-1865-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1.

Entry informationi

Entry nameiG4RLQ5_THETK
AccessioniPrimary (citable) accession number: G4RLQ5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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