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G4RKR5 (G4RKR5_THETK) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glyceraldehyde-3-phosphate dehydrogenase HAMAP-Rule MF_00559
Short name=GAPDH HAMAP-Rule MF_00559
EC=1.2.1.59 HAMAP-Rule MF_00559
Alternative name(s):
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase HAMAP-Rule MF_00559
Gene names
Name:gap HAMAP-Rule MF_00559 EMBL CCC82160.1
Ordered Locus Names:TTX_1534 EMBL CCC82160.1
OrganismThermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) [Complete proteome] [HAMAP]
Taxonomic identifier768679 [NCBI]
Taxonomic lineageArchaea › Crenarchaeota › Thermoprotei › Thermoproteales › Thermoproteaceae › Thermoproteus ›

Protein attributes

Sequence length343 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H. SAAS SAAS006436 HAMAP-Rule MF_00559 RuleBase RU003388

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5. SAAS SAAS006436 HAMAP-Rule MF_00559 RuleBase RU003388

Subunit structure

Homotetramer By similarity. SAAS SAAS006436 HAMAP-Rule MF_00559 RuleBase RU003388

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00559 RuleBase RU003388.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. HAMAP-Rule MF_00559 RuleBase RU000397

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding10 – 112NAD By similarity HAMAP-Rule MF_00559
Region137 – 1393Glyceraldehyde 3-phosphate binding By similarity HAMAP-Rule MF_00559
Region193 – 1942Glyceraldehyde 3-phosphate binding By similarity HAMAP-Rule MF_00559

Sites

Active site1381Nucleophile By similarity HAMAP-Rule MF_00559
Binding site1081NAD; via amide nitrogen By similarity HAMAP-Rule MF_00559
Binding site1671NAD By similarity HAMAP-Rule MF_00559
Binding site3001NAD; via carbonyl oxygen By similarity HAMAP-Rule MF_00559

Sequences

Sequence LengthMass (Da)Tools
G4RKR5 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: F33C598161EF9141

FASTA34337,680
        10         20         30         40         50         60 
MKVAIVGYGT IGKRVADAVS RQDDMTLVGI YKVTPDYEAV AAAQKGYRVF APREKADAFK 

        70         80         90        100        110        120 
KIGVEVEGDL NDLASRADVI VDATPDGVGA QNKELYVKLG KNAIFQGGEE ADVAEVSFNA 

       130        140        150        160        170        180 
LGNYEKALGK RYIRVVSCNT TSITRVLSSL LLNGYKIRRA RVFITRRGAD PKEHKKGPIN 

       190        200        210        220        230        240 
DVVPNPATVP SHHGPDVQTV LEGIDIVTLA VAVPVTIMHM HMAYIELDEA PSKDAVMEAL 

       250        260        270        280        290        300 
ATTPRILLFE TKKGYSSLAQ IIEWARDIGR PRGDVWEVSV LQDSVTVRGN ELYLMYGVHQ 

       310        320        330        340 
EAVVVPENID AIRAMYRLAD KWSSIEKTDK SLGIVTHGKK YNR

« Hide

References

[1]"The complete genome sequence of Thermoproteus tenax: a physiologically versatile member of the Crenarchaeota."
Siebers B., Zaparty M., Raddatz G., Tjaden B., Albers S.V., Bell S.D., Blombach F., Kletzin A., Kyrpides N., Lanz C., Plagens A., Rampp M., Rosinus A., von Jan M., Makarova K.S., Klenk H.P., Schuster S.C., Hensel R.
PLoS ONE 6:E24222-E24222(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FN869859 Genomic DNA. Translation: CCC82160.1.
RefSeqYP_004893238.1. NC_016070.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCCC82160; CCC82160; TTX_1534.
GeneID11262412.
KEGGttn:TTX_1534.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00150.

Enzyme and pathway databases

UniPathwayUPA00109; UER00184.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
HAMAPMF_00559. G3P_dehdrog_arch.
InterProIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006436. Glyceraldehyde-3-P_DH_2_arc.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
SMARTSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01546. GAPDH-II_archae. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG4RKR5_THETK
AccessionPrimary (citable) accession number: G4RKR5
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info