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G4RGJ8

- G4RGJ8_PELHB

UniProt

G4RGJ8 - G4RGJ8_PELHB

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Protein
Ribosomal RNA small subunit methyltransferase A
Gene
rsmA, ksgA, KKY_1022
Organism
Pelagibacterium halotolerans (strain JCM 15775 / CGMCC 1.7692 / B2)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits By similarity.UniRule annotationSAAS annotations

Catalytic activityi

4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281S-adenosyl-L-methionine; via carbonyl oxygen By similarityUniRule annotation
Binding sitei30 – 301S-adenosyl-L-methionine; via amide nitrogen By similarityUniRule annotation
Binding sitei55 – 551S-adenosyl-L-methionine; via carbonyl oxygen By similarityUniRule annotation
Binding sitei77 – 771S-adenosyl-L-methionine By similarityUniRule annotation
Binding sitei103 – 1031S-adenosyl-L-methionine By similarityUniRule annotation
Binding sitei122 – 1221S-adenosyl-L-methionine By similarityUniRule annotation

GO - Molecular functioni

  1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
  2. RNA binding Source: UniProtKB-KW
  3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotations, Transferase

Keywords - Biological processi

rRNA processingUniRule annotationSAAS annotations

Keywords - Ligandi

RNA-bindingUniRule annotationSAAS annotations, S-adenosyl-L-methionineUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciPHAL1082931:GJXT-1019-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
Alternative name(s):
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase
16S rRNA dimethyladenosine transferase
16S rRNA dimethylase
S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase
Gene namesi
Name:rsmAUniRule annotation
Synonyms:ksgAUniRule annotation
Ordered Locus Names:KKY_1022Imported
OrganismiPelagibacterium halotolerans (strain JCM 15775 / CGMCC 1.7692 / B2)Imported
Taxonomic identifieri1082931 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaePelagibacterium
ProteomesiUP000008850: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK02528.
OMAiKMLRQSV.

Family and domain databases

Gene3Di1.10.8.100. 1 hit.
3.40.50.150. 1 hit.
HAMAPiMF_00607. 16SrRNA_methyltr_A.
InterProiIPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR001737. rRNA_Ade_methylase_transferase.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR11727. PTHR11727. 1 hit.
PfamiPF00398. RrnaAD. 1 hit.
[Graphical view]
SMARTiSM00650. rADc. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00755. ksgA. 1 hit.
PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4RGJ8-1 [UniParc]FASTAAdd to Basket

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MSQIDSLPPL REVIAEHGLR AKKELGQNFL LDLNLTARIA RSAGDLTDVT    50
VIEVGPGPGG LTRALLAAGA KKVIAIERDE RALPALAQIS QAYRGRLEVI 100
SADALEIDYR VLAEGRTKIV ANLPYNIATP LLTGWLSQEP WPAWFESLTL 150
MFQREVAERI VARPGDKAYG RLGVLTGWRG DARIAMNLDR NAFTPPPKVT 200
SSVVHIVPKQ VETDVPVRAL EEVTRHAFGQ RRKMIRQSLK GLGVPLEALF 250
GAVGLKGDER AETLPVSTYI AMAREVAKLR G 281
Length:281
Mass (Da):30,722
Last modified:December 14, 2011 - v1
Checksum:i9C2523EC8227D2A0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003075 Genomic DNA. Translation: AEQ51057.1.
RefSeqiYP_004898807.1. NC_016078.1.

Genome annotation databases

EnsemblBacteriaiAEQ51057; AEQ51057; KKY_1022.
GeneIDi11345242.
KEGGiphl:KKY_1022.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003075 Genomic DNA. Translation: AEQ51057.1 .
RefSeqi YP_004898807.1. NC_016078.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEQ51057 ; AEQ51057 ; KKY_1022 .
GeneIDi 11345242.
KEGGi phl:KKY_1022.

Phylogenomic databases

KOi K02528.
OMAi KMLRQSV.

Enzyme and pathway databases

BioCyci PHAL1082931:GJXT-1019-MONOMER.

Family and domain databases

Gene3Di 1.10.8.100. 1 hit.
3.40.50.150. 1 hit.
HAMAPi MF_00607. 16SrRNA_methyltr_A.
InterProi IPR023165. rRNA_Ade_diMease-like.
IPR020596. rRNA_Ade_Mease_Trfase_CS.
IPR001737. rRNA_Ade_methylase_transferase.
IPR020598. rRNA_Ade_methylase_Trfase_N.
IPR011530. rRNA_adenine_dimethylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR11727. PTHR11727. 1 hit.
Pfami PF00398. RrnaAD. 1 hit.
[Graphical view ]
SMARTi SM00650. rADc. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00755. ksgA. 1 hit.
PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 15775 / CGMCC 1.7692 / B2.

Entry informationi

Entry nameiG4RGJ8_PELHB
AccessioniPrimary (citable) accession number: G4RGJ8
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: June 11, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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