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G4RGJ8

- G4RGJ8_PELHB

UniProt

G4RGJ8 - G4RGJ8_PELHB

Protein

Ribosomal RNA small subunit methyltransferase A

Gene

rsmA

Organism
Pelagibacterium halotolerans (strain JCM 15775 / CGMCC 1.7692 / B2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 21 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.UniRule annotationSAAS annotation

    Catalytic activityi

    4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)-dimethyladenine(1519) in 16S rRNA.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei30 – 301S-adenosyl-L-methionine; via amide nitrogenUniRule annotation
    Binding sitei55 – 551S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
    Binding sitei77 – 771S-adenosyl-L-methionineUniRule annotation
    Binding sitei103 – 1031S-adenosyl-L-methionineUniRule annotation
    Binding sitei122 – 1221S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity Source: UniProtKB-EC
    2. RNA binding Source: UniProtKB-KW
    3. rRNA (adenine-N6,N6-)-dimethyltransferase activity Source: InterPro

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    rRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    RNA-bindingUniRule annotationSAAS annotation, S-adenosyl-L-methionineUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPHAL1082931:GJXT-1019-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA small subunit methyltransferase AUniRule annotation (EC:2.1.1.182UniRule annotation)
    Alternative name(s):
    16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferaseUniRule annotation
    16S rRNA dimethyladenosine transferaseUniRule annotation
    16S rRNA dimethylaseUniRule annotation
    S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferaseUniRule annotation
    Gene namesi
    Name:rsmAUniRule annotation
    Synonyms:ksgAUniRule annotation
    Ordered Locus Names:KKY_1022Imported
    OrganismiPelagibacterium halotolerans (strain JCM 15775 / CGMCC 1.7692 / B2)Imported
    Taxonomic identifieri1082931 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaePelagibacterium
    ProteomesiUP000008850: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.UniRule annotation

    Phylogenomic databases

    KOiK02528.
    OMAiKMLRQSV.

    Family and domain databases

    Gene3Di1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPiMF_00607. 16SrRNA_methyltr_A.
    InterProiIPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR11727. PTHR11727. 1 hit.
    PfamiPF00398. RrnaAD. 1 hit.
    [Graphical view]
    SMARTiSM00650. rADc. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00755. ksgA. 1 hit.
    PROSITEiPS01131. RRNA_A_DIMETH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G4RGJ8-1 [UniParc]FASTAAdd to Basket

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    MSQIDSLPPL REVIAEHGLR AKKELGQNFL LDLNLTARIA RSAGDLTDVT    50
    VIEVGPGPGG LTRALLAAGA KKVIAIERDE RALPALAQIS QAYRGRLEVI 100
    SADALEIDYR VLAEGRTKIV ANLPYNIATP LLTGWLSQEP WPAWFESLTL 150
    MFQREVAERI VARPGDKAYG RLGVLTGWRG DARIAMNLDR NAFTPPPKVT 200
    SSVVHIVPKQ VETDVPVRAL EEVTRHAFGQ RRKMIRQSLK GLGVPLEALF 250
    GAVGLKGDER AETLPVSTYI AMAREVAKLR G 281
    Length:281
    Mass (Da):30,722
    Last modified:December 14, 2011 - v1
    Checksum:i9C2523EC8227D2A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003075 Genomic DNA. Translation: AEQ51057.1.
    RefSeqiYP_004898807.1. NC_016078.1.

    Genome annotation databases

    EnsemblBacteriaiAEQ51057; AEQ51057; KKY_1022.
    GeneIDi11345242.
    KEGGiphl:KKY_1022.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003075 Genomic DNA. Translation: AEQ51057.1 .
    RefSeqi YP_004898807.1. NC_016078.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AEQ51057 ; AEQ51057 ; KKY_1022 .
    GeneIDi 11345242.
    KEGGi phl:KKY_1022.

    Phylogenomic databases

    KOi K02528.
    OMAi KMLRQSV.

    Enzyme and pathway databases

    BioCyci PHAL1082931:GJXT-1019-MONOMER.

    Family and domain databases

    Gene3Di 1.10.8.100. 1 hit.
    3.40.50.150. 1 hit.
    HAMAPi MF_00607. 16SrRNA_methyltr_A.
    InterProi IPR023165. rRNA_Ade_diMease-like.
    IPR020596. rRNA_Ade_Mease_Trfase_CS.
    IPR001737. rRNA_Ade_methylase_transferase.
    IPR020598. rRNA_Ade_methylase_Trfase_N.
    IPR011530. rRNA_adenine_dimethylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR11727. PTHR11727. 1 hit.
    Pfami PF00398. RrnaAD. 1 hit.
    [Graphical view ]
    SMARTi SM00650. rADc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00755. ksgA. 1 hit.
    PROSITEi PS01131. RRNA_A_DIMETH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JCM 15775 / CGMCC 1.7692 / B2Imported.

    Entry informationi

    Entry nameiG4RGJ8_PELHB
    AccessioniPrimary (citable) accession number: G4RGJ8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 21 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3