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Protein

Alanine racemase

Gene

KKY_1005

Organism
Pelagibacterium halotolerans (strain JCM 15775 / CGMCC 1.7692 / B2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Active sitei259 – 2591Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei312 – 3121Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPHAL1082931:GJXT-1002-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:KKY_1005Imported
OrganismiPelagibacterium halotolerans (strain JCM 15775 / CGMCC 1.7692 / B2)Imported
Taxonomic identifieri1082931 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaePelagibacterium
ProteomesiUP000008850 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG4RFZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.
OMAiDTGFNRL.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.

Sequencei

Sequence statusi: Complete.

G4RFZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSSKSILGG GITIDLDAIV RNWKALDTVS GKSLTGAVLK ADGYGTGAKT
60 70 80 90 100
VGRALYKAGA RFFFVATPDE GVVLREAIPN AFIFVLDGLI PRTAADYAAH
110 120 130 140 150
GLMPVLASMS QLTEWLDFCL NRGKAAPAAL HFDTGFNRVG FRMKEAELVA
160 170 180 190 200
RELKQSGFEP QMIMSHFACA DQPSHEMTRK QNGLFQGLLN HFPDVPASIA
210 220 230 240 250
NSAAVMSSKD YHYHLVRPGI AMYGGRAING RPNPMAPVIS MDVPILQIKD
260 270 280 290 300
ARIGETVGYG AAYRLRRDTR IAIMALGYAD GYFRGLSGIG GQMGGRVAVN
310 320 330 340 350
GTIVPVLGRI SMDMTAIDIT DVQGLVQPGD PVEILGPNIS IDDVADAART
360 370
IGYEVLTTLN GRFPRSYINV PDGVSLD
Length:377
Mass (Da):40,364
Last modified:December 14, 2011 - v1
Checksum:iEB58639950F343AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003075 Genomic DNA. Translation: AEQ51040.1.
RefSeqiYP_004898790.1. NC_016078.1.

Genome annotation databases

EnsemblBacteriaiAEQ51040; AEQ51040; KKY_1005.
KEGGiphl:KKY_1005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003075 Genomic DNA. Translation: AEQ51040.1.
RefSeqiYP_004898790.1. NC_016078.1.

3D structure databases

ProteinModelPortaliG4RFZ7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEQ51040; AEQ51040; KKY_1005.
KEGGiphl:KKY_1005.

Phylogenomic databases

KOiK01775.
OMAiDTGFNRL.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciPHAL1082931:GJXT-1002-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 15775 / CGMCC 1.7692 / B2Imported.

Entry informationi

Entry nameiG4RFZ7_PELHB
AccessioniPrimary (citable) accession number: G4RFZ7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 29, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.