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G4REV1

- G4REV1_PELHB

UniProt

G4REV1 - G4REV1_PELHB

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Protein

Acetyl-coenzyme A synthetase

Gene

acsA

Organism
Pelagibacterium halotolerans (strain JCM 15775 / CGMCC 1.7692 / B2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Note: Magnesium.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei309 – 3091Coenzyme AUniRule annotation
Binding sitei333 – 3331Coenzyme AUniRule annotation
Binding sitei500 – 5001ATPUniRule annotation
Binding sitei515 – 5151ATPUniRule annotation
Binding sitei523 – 5231Coenzyme A; via carbonyl oxygenUniRule annotation
Binding sitei526 – 5261ATPUniRule annotation
Metal bindingi537 – 5371Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi539 – 5391Magnesium; via carbonyl oxygenUniRule annotation
Metal bindingi542 – 5421Magnesium; via carbonyl oxygenUniRule annotation
Binding sitei584 – 5841Coenzyme AUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi385 – 3873ATPUniRule annotation
Nucleotide bindingi409 – 4146ATPUniRule annotation

GO - Molecular functioni

  1. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  2. AMP binding Source: InterPro
  3. ATP binding Source: UniProtKB-KW
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPHAL1082931:GJXT-1906-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligaseUniRule annotation
Acyl-activating enzymeUniRule annotation
Gene namesi
Name:acsAUniRule annotation
Ordered Locus Names:KKY_1911Imported
OrganismiPelagibacterium halotolerans (strain JCM 15775 / CGMCC 1.7692 / B2)Imported
Taxonomic identifieri1082931 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesHyphomicrobiaceaePelagibacterium
ProteomesiUP000008850: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei609 – 6091N6-acetyllysineUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG4REV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni191 – 1944Coenzyme A bindingUniRule annotation

Sequence similaritiesi

Belongs to the ATP-dependent AMP-binding enzyme family.UniRule annotation

Phylogenomic databases

KOiK01895.
OMAiQTAILFE.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4REV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSEVFAPSD EVVAKTRVTA EQYDRMYRRS VSDPDGFWGE QAQRIDWIKP
60 70 80 90 100
FTKVKNTSFE WPDVSIKWFE DGQLNVAANC IDRHLKEHGD TVAIIFEPDD
110 120 130 140 150
PEAETRHITY RLLHGEVCRF ANVLKELGVQ KGERVTIYMP MIPEAAYAML
160 170 180 190 200
ACARIGAVHS VVFGGFSPDA LAGRVNDCDS RVVITADEGC RGGKKVPLKV
210 220 230 240 250
NVDKALEDCP GVEKVLVVRN TGSDIAMTSG RDVWLHEAEA GVEAVCEPEP
260 270 280 290 300
MNAEDPLFIL YTSGSTGKPK GVLHTTGGYL VYASLTHELT FDYRQGEVFW
310 320 330 340 350
CTADVGWVTG HSYIVYGPLA NGATTLMFEG VPNYPDAGRF WEVVDKHKVN
360 370 380 390 400
IFYTAPTAIR ALMGAGNQFV ERADLSSLRL LGSVGEPINP EAWMWYHKQV
410 420 430 440 450
GRERCIVVDT WWQTETGGFM ITPLPGAIPT KPGSATKPFF GVQPVVLEPE
460 470 480 490 500
SGKVIEETEA AGVLAIADSW PGQMRTVYGD HQRFKETYFQ QYKGYYFTGD
510 520 530 540 550
GCRRDEDGYY WITGRVDDVL NVSGHRLGTA EVESALVAHP KVSEAAVVGF
560 570 580 590 600
PHDVKGQGIY CYVTLMAGEA ASDDLAGELR NWVRKEIGPI ASPDHIQFAP
610 620 630 640
GLPKTRSGKI MRRILRKVAE NDYGALGDTS TLADPGVVDD LIANRKNR
Length:648
Mass (Da):71,561
Last modified:December 14, 2011 - v1
Checksum:i1940E68026A1A373
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003075 Genomic DNA. Translation: AEQ51922.1.
RefSeqiYP_004899672.1. NC_016078.1.

Genome annotation databases

EnsemblBacteriaiAEQ51922; AEQ51922; KKY_1911.
GeneIDi11342874.
KEGGiphl:KKY_1911.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003075 Genomic DNA. Translation: AEQ51922.1 .
RefSeqi YP_004899672.1. NC_016078.1.

3D structure databases

ProteinModelPortali G4REV1.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AEQ51922 ; AEQ51922 ; KKY_1911 .
GeneIDi 11342874.
KEGGi phl:KKY_1911.

Phylogenomic databases

KOi K01895.
OMAi QTAILFE.

Enzyme and pathway databases

BioCyci PHAL1082931:GJXT-1906-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 15775 / CGMCC 1.7692 / B2Imported.

Entry informationi

Entry nameiG4REV1_PELHB
AccessioniPrimary (citable) accession number: G4REV1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3