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Protein
Submitted name:

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Corynebacterium pseudotuberculosis 42/02-A
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431SubstrateUniRule annotation
Sitei252 – 2521Critical for catalysisUniRule annotation
Metal bindingi345 – 3451Magnesium or manganeseUniRule annotation
Sitei415 – 4151Critical for catalysisUniRule annotation
Binding sitei542 – 5421SubstrateUniRule annotation
Metal bindingi543 – 5431Magnesium or manganeseUniRule annotation
Metal bindingi547 – 5471Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: InterPro
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciCPSE1087453:GLBV-467-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Isocitrate dehydrogenase [NADP]Imported
Gene namesi
Name:icdImported
ORF Names:Cp4202_0451Imported
OrganismiCorynebacterium pseudotuberculosis 42/02-AImported
Taxonomic identifieri1087453 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeCorynebacteriaceaeCorynebacterium
ProteomesiUP000002656: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni130 – 1378Substrate bindingUniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.

Sequencei

Sequence statusi: Complete.

G4QWE5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIIYTRTD EAPLLATYSL KPVVEAFAST AGIEVETRDI SLAGRILSQF
60 70 80 90 100
PEFLTEDQKV DDALAELGEL AKTPEANIIK LPNISASVPQ LKAAVTELQS
110 120 130 140 150
QGYKLPNYPD SPSTEEEKDI RARYDAVKGS AVNPVLREGN SDRRAPIAVK
160 170 180 190 200
NFAKKHPHRM GAWSADSKTN VVTMESNDFR HNEKSVIMPD NDTLTIKLVT
210 220 230 240 250
DNGEKVLKDG LKVLKGEVVD GTFISARALD EFLADQVKRA KDEGVLFSAH
260 270 280 290 300
LKATMMKVSD PIIFGHVVRA YFADVFAKYG EQLEAAGLNG ENGLAAIYSG
310 320 330 340 350
LESLPNGAEI KAAFDEALES GADIAMVNSA KGITNLHVPS DVIIDASMPA
360 370 380 390 400
MIRTSGHMWN KNDEEQDTLA VIPDSSYAGV YQTVIADCKK NGAFDPTTMG
410 420 430 440 450
TVPNVGLMAQ KAEEYGSHDK TFKIEANGTV QVVSSAGEVL IEHNVEAGDI
460 470 480 490 500
WRACQAKDAP IQDWVKLAVT RSRLSGMPAV FWLDPERAHD RNLAALVEKY
510 520 530 540 550
LADHDTEGLD IHIMSPVEAT QFSIDRIRRG EDTISVTGNV LRDYNTDLFP
560 570 580 590 600
ILELGTSAKM LSVVPLMAGG GLFETGAGGS APKHVQQLVK ENHLRWDSLG
610 620 630 640 650
EFLALAESLR HFANTEGNTK AGILADTLDR ATETLLNEGY SPSRKAGEID
660 670 680 690 700
NRGSHFFLTK FWAKELSIQS EDADLAATFT PVAEALETHS EDIADALLAV
710 720 730
QGAPADLGGY YHPDDAKTTA VMRPVASYND IISSIK
Length:736
Mass (Da):79,815
Last modified:December 14, 2011 - v1
Checksum:i3797F15423600831
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003062 Genomic DNA. Translation: AEP69717.1.
RefSeqiWP_014522796.1. NC_017306.1.
YP_005691979.1. NC_017306.1.

Genome annotation databases

EnsemblBacteriaiAEP69717; AEP69717; Cp4202_0451.
GeneIDi12851657.
KEGGicos:Cp4202_0451.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003062 Genomic DNA. Translation: AEP69717.1.
RefSeqiWP_014522796.1. NC_017306.1.
YP_005691979.1. NC_017306.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEP69717; AEP69717; Cp4202_0451.
GeneIDi12851657.
KEGGicos:Cp4202_0451.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciCPSE1087453:GLBV-467-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 3 hits.
InterProiIPR004436. Isocitrate_DH_NADP_mono.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PfamiPF03971. IDH. 1 hit.
[Graphical view]
PIRSFiPIRSF009407. IDH_monmr. 1 hit.
TIGRFAMsiTIGR00178. monomer_idh. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 42/02-AImported.

Entry informationi

Entry nameiG4QWE5_CORPS
AccessioniPrimary (citable) accession number: G4QWE5
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: March 4, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.