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Protein

Alanine racemase

Gene

GNIT_0637

Organism
Glaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei134 – 1341SubstrateUniRule annotation
Active sitei256 – 2561Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei304 – 3041Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGNIT1085623:GJU2-637-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:GNIT_0637Imported
OrganismiGlaciecola nitratireducens (strain JCM 12485 / KCTC 12276 / FR1064)Imported
Taxonomic identifieri1085623 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaAlteromonadalesAlteromonadaceaeGlaciecola
ProteomesiUP000009282 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG4QEM7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4QEM7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARHTHAAID LDALTHNFMA MSECSPNSKQ VVVVKADAYG NGAVAVALCL
60 70 80 90 100
QNHADMFAVA FIDEVFELRA AGITQPILVL QGPHQEQECE LTNTLNVVWM
110 120 130 140 150
LHAEQQLNWI NKRIKNKEIN NLHHWVKFDT GMHRLGFMLE DYERLSEDYA
160 170 180 190 200
HIFHAETVVA THLARADEPN NKASLTAIEQ FLNVMVGRHN CLSIANSAAN
210 220 230 240 250
ICLPASAKTW NRMGISLYGS SPFENDEVLV SLQTVMSLNS EVIAIRHIPA
260 270 280 290 300
GESVGYGATW TAQQPSTIAT VAIGYADGYP RHAPIGTPAL IDGHVAKLVG
310 320 330 340 350
RVSMDMLTFD VTDIDNVDIG SPVELWGRNL PINQVAKHIG TIGYELMTRV

SKRVPRKLV
Length:359
Mass (Da):39,577
Last modified:December 13, 2011 - v1
Checksum:i486C1981890210CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003060 Genomic DNA. Translation: AEP28790.1.
RefSeqiYP_004870783.1. NC_016041.1.

Genome annotation databases

EnsemblBacteriaiAEP28790; AEP28790; GNIT_0637.
KEGGigni:GNIT_0637.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003060 Genomic DNA. Translation: AEP28790.1.
RefSeqiYP_004870783.1. NC_016041.1.

3D structure databases

ProteinModelPortaliG4QEM7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEP28790; AEP28790; GNIT_0637.
KEGGigni:GNIT_0637.

Phylogenomic databases

KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciGNIT1085623:GJU2-637-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of seawater bacterium Glaciecola nitratireducens FR1064T."
    Bian F., Qin Q.L., Xie B.B., Shu Y.L., Zhang X.Y., Yu Y., Chen B., Chen X.L., Zhou B.C., Zhang Y.Z.
    J. Bacteriol. 193:7006-7007(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JCM 12485 / KCTC 12276 / FR1064Imported.

Entry informationi

Entry nameiG4QEM7_GLANF
AccessioniPrimary (citable) accession number: G4QEM7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 13, 2011
Last sequence update: December 13, 2011
Last modified: March 31, 2015
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.