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G4Q874 (G4Q874_ACIIR) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO HAMAP-Rule MF_01037
EC=2.1.1.74 HAMAP-Rule MF_01037
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase HAMAP-Rule MF_01037
Folate-dependent tRNA(M-5-U54)-methyltransferase HAMAP-Rule MF_01037
Gene names
Name:trmFO HAMAP-Rule MF_01037
Ordered Locus Names:Acin_1179 EMBL AEQ22405.1
OrganismAcidaminococcus intestini (strain RyC-MR95) [Complete proteome] [HAMAP]
Taxonomic identifier568816 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Negativicutes › Selenomonadales › Acidaminococcaceae › Acidaminococcus ›

Protein attributes

Sequence length442 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity. HAMAP-Rule MF_01037 SAAS SAAS004417

Catalytic activity

5,10-methylenetetrahydrofolate + uridine54 in tRNA + FADH2 = tetrahydrofolate + 5-methyluridine54 in tRNA + FAD. HAMAP-Rule MF_01037 SAAS SAAS004417

Cofactor

FAD By similarity. HAMAP-Rule MF_01037 SAAS SAAS004417

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01037 SAAS SAAS004417.

Sequence similarities

Belongs to the MnmG family. TrmFO subfamily. HAMAP-Rule MF_01037

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 166FAD By similarity HAMAP-Rule MF_01037

Sequences

Sequence LengthMass (Da)Tools
G4Q874 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: CD1F80D36F10853B

FASTA44249,321
        10         20         30         40         50         60 
MKETMTVHVI GAGLAGSEAT WQLVSRKIPV KLHEMRPKKS DPAHHTAYYS ELVCSNSLRA 

        70         80         90        100        110        120 
DNIENAVGLL KEEMRRLDSL IMAQADAHRV PAGGALAVDR MGFAQGVTEA IRNHPLVTVI 

       130        140        150        160        170        180 
EEETIDLSFP EEDYVIVATG PLTSEPLSGA IQNLVSQDYF HFFDAAAPIV TLESINEEIA 

       190        200        210        220        230        240 
YKASRYGKGE AAYYNCPLNK EEYLRFWEAL RTAEVADVKD FEHGMVFEGC MPIEEMAVRG 

       250        260        270        280        290        300 
EDTMRFGPLK PVGLPDPRTG EDPYAVVQLR QDNGAGSLFN MVGFQTHLRW PEQKRVFRMI 

       310        320        330        340        350        360 
PGLEEAEFIR YGVMHKNSYL NSPLLLDADY SLRSHPHLYF AGQMTGVEGY VESAASGLAA 

       370        380        390        400        410        420 
GIYLSRTLSG KAKLLFPRET AIGALSHYIS NPEVKHFQPM NINFGLIAPW DGPRIRGKKE 

       430        440 
KNHAIAMRAL DILENYKNLL HN

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References

[1]"Complete genome sequence of Acidaminococcus intestini RYC-MR95, a Gram-negative bacterium from the phylum Firmicutes."
D'Auria G., Galan J.C., Rodriguez-Alcayna M., Moya A., Baquero F., Latorre A.
J. Bacteriol. 193:7008-7009(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RyC-MR95 EMBL AEQ22405.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003058 Genomic DNA. Translation: AEQ22405.1.
RefSeqYP_004896545.1. NC_016077.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEQ22405; AEQ22405; Acin_1179.
GeneID11264298.
KEGGain:Acin_1179.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK04094.

Enzyme and pathway databases

BioCycAINT568816:GHMB-1178-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 2 hits.
HAMAPMF_01037. TrmFO.
InterProIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
IPR020595. GIDA-rel_CS.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00137. gid_trmFO. 1 hit.
PROSITEPS01281. GIDA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG4Q874_ACIIR
AccessionPrimary (citable) accession number: G4Q874
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 3, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info