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G4Q2T8 (G4Q2T8_ACIIR) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddlA EMBL AEQ22744.1
Synonyms:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Acin_1525 EMBL AEQ22744.1
OrganismAcidaminococcus intestini (strain RyC-MR95) [Complete proteome] [HAMAP] EMBL AEQ22744.1
Taxonomic identifier568816 [NCBI]
Taxonomic lineageBacteriaFirmicutesNegativicutesSelenomonadalesAcidaminococcaceaeAcidaminococcus

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain104 – 307204ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding133 – 18856ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2611Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2741Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2761Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
G4Q2T8 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: 923E7CD09C4DD86A

FASTA31233,567
        10         20         30         40         50         60 
MMKTKRIGVV MGGPSKEREV SLNTGSAIVE ALKEKGYDAV PIDLDPSLFP SQIEDAGVKV 

        70         80         90        100        110        120 
VFNAVHGLYG EDGRLQAVLE MLGVPYTGSG VLSSAIAMNK FYTKRMFEAN GVKTANCLYL 

       130        140        150        160        170        180 
TDKDRQTAKQ DIIRKLGIPC VVKPAEQGSS IGVTIVKKEE DLDKALEEAF SYGKLVLAEA 

       190        200        210        220        230        240 
FFTGKEVAAG VMMDSSGNPI AMPLVLIEPH VDFYDYHNKY TKGATTYTCP APFDECLTKA 

       250        260        270        280        290        300 
LQEEAVKAYK ALGCSGVARV DEMVDAEGNF ICLEVNTIPG MTATSLVPKA AKAMGLSFPD 

       310 
LCEKILETAH LG 

« Hide

References

[1]"Complete Genome Sequence of Acidaminococcus intestini RYC-MR95, a Gram-Negative Bacterium from the Phylum Firmicutes."
D'Auria G., Galan J.C., Rodriguez-Alcayna M., Moya A., Baquero F., Latorre A.
J. Bacteriol. 193:7008-7009(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RyC-MR95 EMBL AEQ22744.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003058 Genomic DNA. Translation: AEQ22744.1.
RefSeqYP_004896884.1. NC_016077.1.

3D structure databases

ProteinModelPortalG4Q2T8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEQ22744; AEQ22744; Acin_1525.
GeneID11264928.
KEGGain:Acin_1525.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycAINT568816:GHMB-1521-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG4Q2T8_ACIIR
AccessionPrimary (citable) accession number: G4Q2T8
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)