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G4PRS1 (G4PRS1_ECOLX) Unreviewed, UniProtKB/TrEMBL

Last modified January 22, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446

EC=1.1.1.42 RuleBase RU004446
Gene names
Name:icdA EMBL AEQ12061.1
ORF Names:CE10_1241 EMBL AEQ12061.1
OrganismEscherichia coli O7:K1 str. CE10 [Complete proteome] EMBL AEQ12061.1
Taxonomic identifier1072459 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Sequences

Sequence LengthMass (Da)Tools
G4PRS1 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: 9A02EEFCB3B4FDD9

FASTA41645,770
        10         20         30         40         50         60 
MESKVVVPAQ GKKITLQNGK LNVPENPIIP YIEGDGIGVD VTPAMLKVVD AAVEKAYKGE 

        70         80         90        100        110        120 
RKISWMEIYT GEKSTQVYGQ DVWLPAETLD LIREYRVAIK GPLTTPVGGG IRSLNVALRQ 

       130        140        150        160        170        180 
ELDLYICLRP VRYYQGTPSP VKHPELTDMV IFRENSEDIY AGIEWKADSA DAEKVIKFLR 

       190        200        210        220        230        240 
EEMGVKKIRF PEHCGIGIKP CSEEGTKRLV RAAIEYAIAN DRDSVTLVHK GNIMKFTEGA 

       250        260        270        280        290        300 
FKDWGYQLAR EEFGGELIDG GPWLKVKNPN TGKEIVIKDV IADAFLQQIL LRPAEYDVIA 

       310        320        330        340        350        360 
CMNLNGDYIS DALAAQVGGI GIAPGANIGD ECALFEATHG TAPKYAGQDK VNPGSIILSA 

       370        380        390        400        410 
EMMLRHMGWT EAADLIVKGM EGAINAKTVT YDFERLMEGA KLLKCSEFGD AIIKNM 

« Hide

References

[1]"Complete Genome Sequence of the Neonatal-Meningitis-Associated Escherichia coli Strain CE10."
Lu S., Zhang X., Zhu Y., Kim K.S., Yang J., Jin Q.
J. Bacteriol. 193:7005-7005(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CE10 EMBL AEQ12061.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003034 Genomic DNA. Translation: AEQ12061.1.
RefSeqYP_006143345.1. NC_017646.1.

3D structure databases

ProteinModelPortalG4PRS1.
SMRG4PRS1. Positions 1-416.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEQ12061; AEQ12061; CE10_1241.
GeneID12674046.
KEGGeoc:CE10_1241.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Enzyme and pathway databases

BioCycECOL1072459:GLD5-1241-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11835. PTHR11835. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsTIGR00183. prok_nadp_idh. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG4PRS1_ECOLX
AccessionPrimary (citable) accession number: G4PRS1
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: January 22, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)