Skip Header

Contribute Send feedback
Read comments (?) or add your own

G4NZU3 (G4NZU3_BACPN) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
S-ribosylhomocysteine lyase HAMAP-Rule MF_00091
EC=4.4.1.21 HAMAP-Rule MF_00091
Alternative name(s):
AI-2 synthesis protein HAMAP-Rule MF_00091
Autoinducer-2 production protein LuxS HAMAP-Rule MF_00091
Gene names
Name:luxS HAMAP-Rule MF_00091 EMBL AEP87922.1
ORF Names:GYO_3320 EMBL AEP87922.1
OrganismBacillus subtilis subsp. spizizenii TU-B-10 EMBL AEP87922.1
Taxonomic identifier1052585 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length157 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity. SAAS SAAS003815 HAMAP-Rule MF_00091

Catalytic activity

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione. SAAS SAAS003815 HAMAP-Rule MF_00091

Cofactor

Binds 1 iron ion per subunit By similarity. SAAS SAAS003815 HAMAP-Rule MF_00091

Subunit structure

Homodimer By similarity. SAAS SAAS003815 HAMAP-Rule MF_00091

Sequence similarities

Belongs to the LuxS family. HAMAP-Rule MF_00091

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding541Iron By similarity HAMAP-Rule MF_00091
Metal binding581Iron By similarity HAMAP-Rule MF_00091
Metal binding1261Iron By similarity HAMAP-Rule MF_00091

Sequences

Sequence LengthMass (Da)Tools
G4NZU3 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: DD011A298BBD2CF8

FASTA15717,724
        10         20         30         40         50         60 
MPSVESFELD HNAVVAPYVR HCGVHKVGTD GVVNKFDIRF CQPNKQAMKP DTIHTLEHLL 

        70         80         90        100        110        120 
AFTIRSHAEK YDHFDIIDIS PMGCQTGYYL VVSGEPTPAE IVDLLEDTMK EAVEITEIPA 

       130        140        150 
ANEKQCGQAK LHDLEGAKRL MRFWLSQDKE ELLKVFG

« Hide

References

[1]"Whole-Genome Sequences of Bacillus subtilis and Close Relatives."
Earl A.M., Eppinger M., Fricke W.F., Rosovitz M.J., Rasko D.A., Daugherty S., Losick R., Kolter R., Ravel J.
J. Bacteriol. 194:2378-2379(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: TU-B-10 EMBL AEP87922.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002905 Genomic DNA. Translation: AEP87922.1.
RefSeqYP_004878554.1. NC_016047.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAEP87922; AEP87922; GYO_3320.
GeneID11240654.
KEGGbst:GYO_3320.

Phylogenomic databases

KOK07173.

Enzyme and pathway databases

BioCycBSUB1052585:GJWW-3287-MONOMER.

Family and domain databases

Gene3D3.30.1360.80. 1 hit.
HAMAPMF_00091. LuxS.
InterProIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFPIRSF006160. AI2. 1 hit.
PRINTSPR01487. LUXSPROTEIN.
ProDomPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF63411. Metalloenz_metal-bd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG4NZU3_BACPN
AccessionPrimary (citable) accession number: G4NZU3
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 3, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info