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Protein

Histidine ammonia-lyase

Gene

hutH

Organism
Bacillus subtilis subsp. spizizenii (strain TU-B-10)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidine = urocanate + NH3.UniRule annotationSAAS annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (hutH)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processHistidine metabolismUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00379; UER00549

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine ammonia-lyaseUniRule annotationSAAS annotation (EC:4.3.1.3UniRule annotationSAAS annotation)
Short name:
HistidaseUniRule annotation
Gene namesi
Name:hutHUniRule annotationImported
Ordered Locus Names:GYO_4342Imported
OrganismiBacillus subtilis subsp. spizizenii (strain TU-B-10)Imported
Taxonomic identifieri1052585 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000002651 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki141 ↔ 1435-imidazolinone (Ala-Gly)UniRule annotation
Modified residuei1422,3-didehydroalanine (Ser)UniRule annotation1

Post-translational modificationi

Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.UniRule annotation
Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG4NYK7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAL/histidase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01745
OMAiCAPQVAG

Family and domain databases

CDDicd00332 PAL-HAL, 1 hit
Gene3Di1.10.275.101 hit
HAMAPiMF_00229 His_ammonia_lyase, 1 hit
InterProiView protein in InterPro
IPR001106 Aromatic_Lyase
IPR024083 Fumarase/histidase_N
IPR005921 HutH
IPR008948 L-Aspartase-like
IPR022313 Phe/His_NH3-lyase_AS
PANTHERiPTHR10362 PTHR10362, 1 hit
PfamiView protein in Pfam
PF00221 Lyase_aromatic, 1 hit
SUPFAMiSSF48557 SSF48557, 1 hit
TIGRFAMsiTIGR01225 hutH, 1 hit
PROSITEiView protein in PROSITE
PS00488 PAL_HISTIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

G4NYK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVILDGSSLT TTDVARVLFD FEEAAASEES MERVKKSRAA VERIVHEEKT
60 70 80 90 100
IYGITTGFGK FSDVLIQKED SAALQLNLIL SHACGVGDPF PECVSRAMLL
110 120 130 140 150
LRANALLKGF SGVRAELIEQ LLAFLNKRVH PVIPQQGSLG ASGDLAPLSH
160 170 180 190 200
LALALIGQGE VFFEGERMPA MTGLKKAGIQ PVTLTSKEGL ALINGTQAMT
210 220 230 240 250
AMGVVSYIEA EKLAYQTERI ASLTIEGLRG IIDAFDEDIH LARGYQEQID
260 270 280 290 300
VAERIRFYLS DSSLTTSQGE LRVQDAYSLR CIPQVHGATW QTLGYVKEKL
310 320 330 340 350
EIEMNAATDN PLIFNDGDKV ISGGNFHGQP IAFAMDFLKI AISELANIAE
360 370 380 390 400
RRIERLVNPQ LNDLPPFLSP HPGLQSGAMI MQYAAASLVS ENKTLAHPAS
410 420 430 440 450
VDSIPSSANQ EDHVSMGTIA ARHAYQVIAN ARRVIAIEAI CALQAVEYRG
460 470 480 490 500
IEHAASYTKQ LFQEMRKVVP SIQQDRVFSY DIERLTDWLK KESLLPDHQN

EELRGMNI
Length:508
Mass (Da):55,744
Last modified:December 14, 2011 - v1
Checksum:i675F2BAAF1A118CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002905 Genomic DNA Translation: AEP88900.1
RefSeqiWP_014115737.1, NC_016047.1

Genome annotation databases

EnsemblBacteriaiAEP88900; AEP88900; GYO_4342
KEGGibst:GYO_4342

Similar proteinsi

Entry informationi

Entry nameiG4NYK7_BACPT
AccessioniPrimary (citable) accession number: G4NYK7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: March 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported