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Protein

Malate dehydrogenase

Gene

mdh

Organism
Chlamydia trachomatis serovar A (strain A2497)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104SubstrateUniRule annotation1
Binding sitei110SubstrateUniRule annotation1
Binding sitei117NADUniRule annotation1
Binding sitei124NADUniRule annotation1
Binding sitei143SubstrateUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Active sitei199Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 29NADUniRule annotation7
Nucleotide bindingi141 – 143NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotationSAAS annotation (EC:1.1.1.37UniRule annotationSAAS annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:CTO_0410Imported
OrganismiChlamydia trachomatis serovar A (strain A2497)Imported
Taxonomic identifieri580047 [NCBI]
Taxonomic lineageiBacteriaChlamydiaeChlamydialesChlamydiaceaeChlamydia/Chlamydophila groupChlamydia
Proteomesi
  • UP000009287 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliG4NMW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 164Ldh_1_NInterPro annotationAdd BLAST147
Domaini169 – 332Ldh_1_CInterPro annotationAdd BLAST164

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

Phylogenomic databases

KOiK00024.
OMAiRPRTKGM.
OrthoDBiPOG091H03R4.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_01517. Malate_dehydrog_2. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR010945. Malate_DH_type2.
IPR036291. NAD(P)-bd_dom_sf.
PANTHERiPTHR23382. PTHR23382. 1 hit.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

Sequencei

Sequence statusi: Complete.

G4NMW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFVKVKRGW LMVSQTVSVA VTGGTGQIAY SFLFSLAHGD VFGLDCGIDL
60 70 80 90 100
RIYDIPGTER ALSGVRMELD DGAFPLLQRV QVTTSLHDAF DGIDAAFLIG
110 120 130 140 150
SVPRGPGMER RDLLKKNGEI FATQGKALNT TAKRDAKIFV VGNPVNTNCW
160 170 180 190 200
IAMNHAPRLL RKNFHAMLRL DQNRMHSMLS HRAEVPLSAV SQVVVWGNHS
210 220 230 240 250
AKQVPDFTQA LINDRPIAET IADRDWLENI MVPSVQSRGS AVIEARGKSS
260 270 280 290 300
AASAARALAE AARSIYQPKE GEWFSSGVCS DHNPYGLPED LIFGFPCRML
310 320 330
ATGEYEVIPR LPWDAFIRGK MQISLDEILQ EKASVSL
Length:337
Mass (Da):37,110
Last modified:December 14, 2011 - v1
Checksum:iBFD61182FA9EE8CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002401 Genomic DNA. Translation: AEP35226.1.

Genome annotation databases

EnsemblBacteriaiAEP35226; AEP35226; CTO_0410.
KEGGicra:CTO_0410.
PATRICifig|580047.4.peg.417.

Similar proteinsi

Entry informationi

Entry nameiG4NMW2_CHLT4
AccessioniPrimary (citable) accession number: G4NMW2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 22, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported