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G4N5E7

- G4N5E7_MAGO7

UniProt

G4N5E7 - G4N5E7_MAGO7

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

MGG_05254

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei380 – 3801S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
ORF Names:MGG_05254Imported
OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)Imported
Taxonomic identifieri242507 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
ProteomesiUP000009058: Chromosome 3

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni330 – 3334S-adenosyl-L-methionine bindingUniRule annotation
Regioni354 – 36310S-adenosyl-L-methionine bindingUniRule annotation
Regioni416 – 4172S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

Phylogenomic databases

InParanoidiG4N5E7.
KOiK11427.
OrthoDBiEOG7KH9VN.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4N5E7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGILAQKSKF KIAKPTIRVE KVAVEVPQAR AKPSRPLGGG GADRASSGSP
60 70 80 90 100
RPQQPQPPRV RASASPLPFA SSSRASSSLT SSGAQQYQRK RKASSAGPAA
110 120 130 140 150
APRRSPANSD RVTWDQESDS EDDNAWEDTL DDRKRQRTTD SERAEDPNRR
160 170 180 190 200
LVSPALTDPP PDGRDLRLIH AADVASLKLK CTPSLGAPAS DVRVALQYPG
210 220 230 240 250
LRQRERYELV SGKDMIDAVE EIKHVINCVV DTYLTENEAR PFTDANNGLI
260 270 280 290 300
RQLERSSNLK DYKAFRAALD KYNLRLRELQ ESGAIARNLA KRHLLPFNLV
310 320 330 340 350
QLILQQVYDR TVAPRVELLA KYENGTDNVY GELLHPFISE ILVQRLKMRS
360 370 380 390 400
DQVFVDLGSG VGNVVLQAAL DIGCESWGCE MMENACNLAD AQKKEFTARC
410 420 430 440 450
RLWGIAPGKV RLERGDFRTN ERTLSALKRA DVVLVNNQAF TAQLNDDLVR
460 470 480 490 500
IFLDLRKGCK IVSLKSFVHE QKNAANDVGS SILDVERLSY PEGYVSWTGA
510
GGQFCISTRK
Length:510
Mass (Da):56,478
Last modified:December 14, 2011 - v1
Checksum:i32D99BA492090DA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001233 Genomic DNA. Translation: EHA53004.1.
RefSeqiXP_003712811.1. XM_003712763.1.

Genome annotation databases

EnsemblFungiiMGG_05254T0; MGG_05254T0; MGG_05254.
GeneIDi2675467.
KEGGimgr:MGG_05254.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001233 Genomic DNA. Translation: EHA53004.1 .
RefSeqi XP_003712811.1. XM_003712763.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii MGG_05254T0 ; MGG_05254T0 ; MGG_05254 .
GeneIDi 2675467.
KEGGi mgr:MGG_05254.

Phylogenomic databases

InParanoidi G4N5E7.
KOi K11427.
OrthoDBi EOG7KH9VN.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 70-15 / ATCC MYA-4617 / FGSC 8958Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 70-15.

Entry informationi

Entry nameiG4N5E7_MAGO7
AccessioniPrimary (citable) accession number: G4N5E7
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: October 29, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3