G4N5E7 (G4N5E7_MAGO7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific PIRNR PIRNR017570
EC=2.1.1.43 PIRNR PIRNR017570

Alternative name(s):
Histone H3-K79 methyltransferase PIRNR PIRNR017570

Gene names

ORF Names:

MGG_05254 EMBL EHA53004.1

Organism

Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome] EMBL EHA53004.1

Taxonomic identifier

242507 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › sordariomyceta › Sordariomycetes › Sordariomycetidae › Magnaporthales › Magnaporthaceae › Magnaporthe › Magnaporthe oryzae

Protein attributes

Sequence length	510 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. PIRNR PIRNR017570
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR017570
Subcellular location	Nucleus By similarity PIRNR PIRNR017570.
Sequence similarities	Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. PIRNR PIRNR017570

Ontologies

Keywords
Biological process	Transcription Transcription regulation PIRNR PIRNR017570
Cellular component	Nucleus PIRNR PIRNR017570
Ligand	S-adenosyl-L-methionine PIRNR PIRNR017570
Molecular function	Chromatin regulator PIRNR PIRNR017570 Methyltransferase PIRNR PIRNR017570 EMBL EHA53004.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	histone lysine methylation Inferred from electronic annotation. Source: GOC regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	histone-lysine N-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G4N5E7 [UniParc]. Last modified December 14, 2011. Version 1. Checksum: 32D99BA492090DA3	FASTA	510	56,478
	10 20 30 40 50 60 MGILAQKSKF KIAKPTIRVE KVAVEVPQAR AKPSRPLGGG GADRASSGSP RPQQPQPPRV 70 80 90 100 110 120 RASASPLPFA SSSRASSSLT SSGAQQYQRK RKASSAGPAA APRRSPANSD RVTWDQESDS 130 140 150 160 170 180 EDDNAWEDTL DDRKRQRTTD SERAEDPNRR LVSPALTDPP PDGRDLRLIH AADVASLKLK 190 200 210 220 230 240 CTPSLGAPAS DVRVALQYPG LRQRERYELV SGKDMIDAVE EIKHVINCVV DTYLTENEAR 250 260 270 280 290 300 PFTDANNGLI RQLERSSNLK DYKAFRAALD KYNLRLRELQ ESGAIARNLA KRHLLPFNLV 310 320 330 340 350 360 QLILQQVYDR TVAPRVELLA KYENGTDNVY GELLHPFISE ILVQRLKMRS DQVFVDLGSG 370 380 390 400 410 420 VGNVVLQAAL DIGCESWGCE MMENACNLAD AQKKEFTARC RLWGIAPGKV RLERGDFRTN 430 440 450 460 470 480 ERTLSALKRA DVVLVNNQAF TAQLNDDLVR IFLDLRKGCK IVSLKSFVHE QKNAANDVGS 490 500 510 SILDVERLSY PEGYVSWTGA GGQFCISTRK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of the rice blast fungus Magnaporthe grisea." Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K., Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D., Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S., Soanes D.M. , Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M., Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E., Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W. Nature 434:980-986(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 70-15 / ATCC MYA-4617 / FGSC 8958.
[2]	"The Genome Sequence of Magnaporthe oryzae 70-15." The Broad Institute Genome Sequencing Platform Ma L.-J., Dead R., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A., Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M. , Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A., MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Yandava C., Wortman J., Nusbaum C., Birren B. Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 70-15.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CM001233 Genomic DNA. Translation: EHA53004.1.
RefSeq	XP_003712811.1. XM_003712763.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	MGG_05254T0; MGG_05254T0; MGG_05254.
GeneID	2675467.
KEGG	mgr:MGG_05254.
Phylogenomic databases
KO	K11427.
Family and domain databases
InterPro	IPR013110. DOT1. IPR025789. Histone_H3-K79_MeTrfase. IPR021162. Histone_H3-K79_MeTrfase_fungi. [Graphical view]
Pfam	PF08123. DOT1. 1 hit. [Graphical view]
PIRSF	PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
PROSITE	PS51569. DOT1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G4N5E7_MAGO7

Accession

Primary (citable) accession number: G4N5E7

Entry history

Integrated into UniProtKB/TrEMBL:	December 14, 2011
Last sequence update:	December 14, 2011
Last modified:	January 9, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)