Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

G4N5E7

- G4N5E7_MAGO7

UniProt

G4N5E7 - G4N5E7_MAGO7

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

MGG_05254

Organism
Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei380 – 3801S-adenosyl-L-methionineUniRule annotation

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferaseUniRule annotation
    Gene namesi
    ORF Names:MGG_05254Imported
    OrganismiMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)Imported
    Taxonomic identifieri242507 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe
    ProteomesiUP000009058: Chromosome 3

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni330 – 3334S-adenosyl-L-methionine bindingUniRule annotation
    Regioni354 – 36310S-adenosyl-L-methionine bindingUniRule annotation
    Regioni416 – 4172S-adenosyl-L-methionine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7KH9VN.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G4N5E7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGILAQKSKF KIAKPTIRVE KVAVEVPQAR AKPSRPLGGG GADRASSGSP    50
    RPQQPQPPRV RASASPLPFA SSSRASSSLT SSGAQQYQRK RKASSAGPAA 100
    APRRSPANSD RVTWDQESDS EDDNAWEDTL DDRKRQRTTD SERAEDPNRR 150
    LVSPALTDPP PDGRDLRLIH AADVASLKLK CTPSLGAPAS DVRVALQYPG 200
    LRQRERYELV SGKDMIDAVE EIKHVINCVV DTYLTENEAR PFTDANNGLI 250
    RQLERSSNLK DYKAFRAALD KYNLRLRELQ ESGAIARNLA KRHLLPFNLV 300
    QLILQQVYDR TVAPRVELLA KYENGTDNVY GELLHPFISE ILVQRLKMRS 350
    DQVFVDLGSG VGNVVLQAAL DIGCESWGCE MMENACNLAD AQKKEFTARC 400
    RLWGIAPGKV RLERGDFRTN ERTLSALKRA DVVLVNNQAF TAQLNDDLVR 450
    IFLDLRKGCK IVSLKSFVHE QKNAANDVGS SILDVERLSY PEGYVSWTGA 500
    GGQFCISTRK 510
    Length:510
    Mass (Da):56,478
    Last modified:December 14, 2011 - v1
    Checksum:i32D99BA492090DA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001233 Genomic DNA. Translation: EHA53004.1.
    RefSeqiXP_003712811.1. XM_003712763.1.

    Genome annotation databases

    EnsemblFungiiMGG_05254T0; MGG_05254T0; MGG_05254.
    GeneIDi2675467.
    KEGGimgr:MGG_05254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CM001233 Genomic DNA. Translation: EHA53004.1 .
    RefSeqi XP_003712811.1. XM_003712763.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii MGG_05254T0 ; MGG_05254T0 ; MGG_05254 .
    GeneIDi 2675467.
    KEGGi mgr:MGG_05254.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7KH9VN.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021162. Histone_H3-K79_MeTrfase_fungi.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 70-15 / ATCC MYA-4617 / FGSC 8958Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 70-15.

    Entry informationi

    Entry nameiG4N5E7_MAGO7
    AccessioniPrimary (citable) accession number: G4N5E7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3