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G4N5E7 (G4N5E7_MAGO7) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific PIRNR PIRNR017570

EC=2.1.1.43 PIRNR PIRNR017570
Alternative name(s):
Histone H3-K79 methyltransferase PIRNR PIRNR017570
Gene names
ORF Names:MGG_05254 EMBL EHA53004.1
OrganismMagnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae) [Complete proteome] EMBL EHA53004.1
Taxonomic identifier242507 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesSordariomycetidaeMagnaporthalesMagnaporthaceaeMagnaporthe

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones By similarity. PIRNR PIRNR017570

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. PIRNR PIRNR017570

Subcellular location

Nucleus By similarity PIRNR PIRNR017570.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. PIRNR PIRNR017570

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region330 – 3334S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region354 – 36310S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1
Region416 – 4172S-adenosyl-L-methionine binding By similarity PIRSR PIRSR017570-1

Sites

Binding site3801S-adenosyl-L-methionine By similarity PIRSR PIRSR017570-1

Sequences

Sequence LengthMass (Da)Tools
G4N5E7 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: 32D99BA492090DA3

FASTA51056,478
        10         20         30         40         50         60 
MGILAQKSKF KIAKPTIRVE KVAVEVPQAR AKPSRPLGGG GADRASSGSP RPQQPQPPRV 

        70         80         90        100        110        120 
RASASPLPFA SSSRASSSLT SSGAQQYQRK RKASSAGPAA APRRSPANSD RVTWDQESDS 

       130        140        150        160        170        180 
EDDNAWEDTL DDRKRQRTTD SERAEDPNRR LVSPALTDPP PDGRDLRLIH AADVASLKLK 

       190        200        210        220        230        240 
CTPSLGAPAS DVRVALQYPG LRQRERYELV SGKDMIDAVE EIKHVINCVV DTYLTENEAR 

       250        260        270        280        290        300 
PFTDANNGLI RQLERSSNLK DYKAFRAALD KYNLRLRELQ ESGAIARNLA KRHLLPFNLV 

       310        320        330        340        350        360 
QLILQQVYDR TVAPRVELLA KYENGTDNVY GELLHPFISE ILVQRLKMRS DQVFVDLGSG 

       370        380        390        400        410        420 
VGNVVLQAAL DIGCESWGCE MMENACNLAD AQKKEFTARC RLWGIAPGKV RLERGDFRTN 

       430        440        450        460        470        480 
ERTLSALKRA DVVLVNNQAF TAQLNDDLVR IFLDLRKGCK IVSLKSFVHE QKNAANDVGS 

       490        500        510 
SILDVERLSY PEGYVSWTGA GGQFCISTRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CM001233 Genomic DNA. Translation: EHA53004.1.
RefSeqXP_003712811.1. XM_003712763.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiMGG_05254T0; MGG_05254T0; MGG_05254.
GeneID2675467.
KEGGmgr:MGG_05254.

Phylogenomic databases

KOK11427.
OrthoDBEOG7KH9VN.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021162. Histone_H3-K79_MeTrfase_fungi.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF017570. Histone_H3-K79_MeTrfase. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG4N5E7_MAGO7
AccessionPrimary (citable) accession number: G4N5E7
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: June 11, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)