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Protein

Isoprenyl transferase

Gene

uppS

Organism
Tetragenococcus halophilus (strain DSM 20338 / JCM 20259 / NCIMB 9735 / NBRC 12172) (Pediococcus halophilus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei35UniRule annotation1
Metal bindingi35MagnesiumUniRule annotation1
Binding sitei40SubstrateUniRule annotation1
Binding sitei48SubstrateUniRule annotation1
Binding sitei52SubstrateUniRule annotation1
Active sitei83Proton acceptorUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Binding sitei86SubstrateUniRule annotation1
Binding sitei207SubstrateUniRule annotation1
Metal bindingi226MagnesiumUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotationImported
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSImported
Ordered Locus Names:TEH_19640Imported
OrganismiTetragenococcus halophilus (strain DSM 20338 / JCM 20259 / NCIMB 9735 / NBRC 12172) (Pediococcus halophilus)Imported
Taxonomic identifieri945021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeTetragenococcus
Proteomesi
  • UP000002663 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi945021.TEH_19640

Structurei

3D structure databases

ProteinModelPortaliG4L2G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni36 – 39Substrate bindingUniRule annotation4
Regioni80 – 82Substrate bindingUniRule annotation3
Regioni213 – 215Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CR3 Bacteria
COG0020 LUCA
KOiK00806
OMAiFDRRDLW
OrthoDBiPOG091H00BZ

Family and domain databases

CDDicd00475 Cis_IPPS, 1 hit
Gene3Di3.40.1180.10, 1 hit
HAMAPiMF_01139 ISPT, 1 hit
InterProiView protein in InterPro
IPR001441 UPP_synth-like
IPR018520 UPP_synth-like_CS
IPR036424 UPP_synth-like_sf
PANTHERiPTHR10291 PTHR10291, 1 hit
PfamiView protein in Pfam
PF01255 Prenyltransf, 1 hit
SUPFAMiSSF64005 SSF64005, 1 hit
TIGRFAMsiTIGR00055 uppS, 1 hit
PROSITEiView protein in PROSITE
PS01066 UPP_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

G4L2G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFFPEKNK TFQEEQEYTF DSELPVPKHI AIIMDGNGRW AQNRRLPRVA
60 70 80 90 100
GHKEGMETVK KITKHASYLG VKVLTLYAFS TENWRRPEEE VNFLMQLPVD
110 120 130 140 150
FFDTFVPELM KENVRVNVMG EYDVLPAHTQ DAVNRAVKQT SENTGMILNF
160 170 180 190 200
ALNYGSRAEM VSAVKNIATD ISAKNIEVEQ IDDDFIADYL MTGFLPKEIR
210 220 230 240 250
DPEVLIRTSG EERISNFLLW QIAYSELLFT KELWPDYSEA SLENSIAIFQ
260
HRNRRFGGLK NKEENK
Length:266
Mass (Da):30,879
Last modified:December 14, 2011 - v1
Checksum:iA89297E9ADDB925F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012046 Genomic DNA Translation: BAK95291.1
RefSeqiWP_014125332.1, NC_016052.1

Genome annotation databases

EnsemblBacteriaiBAK95291; BAK95291; TEH_19640
GeneIDi35861587
KEGGithl:TEH_19640
PATRICifig|945021.8.peg.2007

Similar proteinsi

Entry informationi

Entry nameiG4L2G2_TETHN
AccessioniPrimary (citable) accession number: G4L2G2
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 25, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health