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Protein

Isoprenyl transferase

Gene

uppS

Organism
Tetragenococcus halophilus (strain DSM 20338 / JCM 20259 / NCIMB 9735 / NBRC 12172) (Pediococcus halophilus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei35 – 351UniRule annotation
Metal bindingi35 – 351MagnesiumUniRule annotation
Binding sitei40 – 401SubstrateUniRule annotation
Binding sitei48 – 481SubstrateUniRule annotation
Binding sitei52 – 521SubstrateUniRule annotation
Active sitei83 – 831Proton acceptorUniRule annotation
Binding sitei84 – 841SubstrateUniRule annotation
Binding sitei86 – 861SubstrateUniRule annotation
Binding sitei207 – 2071SubstrateUniRule annotation
Metal bindingi226 – 2261MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciTHAL945021:GJV6-1985-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSImported
Ordered Locus Names:TEH_19640Imported
OrganismiTetragenococcus halophilus (strain DSM 20338 / JCM 20259 / NCIMB 9735 / NBRC 12172) (Pediococcus halophilus)Imported
Taxonomic identifieri945021 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeTetragenococcus
ProteomesiUP000002663 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi945021.TEH_19640.

Structurei

3D structure databases

ProteinModelPortaliG4L2G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

KOiK00806.
OMAiYQNRERR.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4L2G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRFFPEKNK TFQEEQEYTF DSELPVPKHI AIIMDGNGRW AQNRRLPRVA
60 70 80 90 100
GHKEGMETVK KITKHASYLG VKVLTLYAFS TENWRRPEEE VNFLMQLPVD
110 120 130 140 150
FFDTFVPELM KENVRVNVMG EYDVLPAHTQ DAVNRAVKQT SENTGMILNF
160 170 180 190 200
ALNYGSRAEM VSAVKNIATD ISAKNIEVEQ IDDDFIADYL MTGFLPKEIR
210 220 230 240 250
DPEVLIRTSG EERISNFLLW QIAYSELLFT KELWPDYSEA SLENSIAIFQ
260
HRNRRFGGLK NKEENK
Length:266
Mass (Da):30,879
Last modified:December 14, 2011 - v1
Checksum:iA89297E9ADDB925F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012046 Genomic DNA. Translation: BAK95291.1.
RefSeqiWP_014125332.1. NC_016052.1.

Genome annotation databases

EnsemblBacteriaiBAK95291; BAK95291; TEH_19640.
KEGGithl:TEH_19640.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012046 Genomic DNA. Translation: BAK95291.1.
RefSeqiWP_014125332.1. NC_016052.1.

3D structure databases

ProteinModelPortaliG4L2G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi945021.TEH_19640.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAK95291; BAK95291; TEH_19640.
KEGGithl:TEH_19640.

Phylogenomic databases

KOiK00806.
OMAiYQNRERR.

Enzyme and pathway databases

BioCyciTHAL945021:GJV6-1985-MONOMER.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Whole genome sequence of Tetragenococcus halophilus NBRC 12172."
    Nakazawa H., Omata S., Koga C., Watanabe Y., Katano Y., Ito N., Tsukatani N., Ankai A., Oguchi A., Fukui S., Yashiro I., Kamata S., Hashimoto Y., Yamazaki J., Taguchi H., Tanaka A., Koyama T., Ichige A.
    , Hanya Y., Tanikawa S., Yamazaki S., Fujita N.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 20338 / JCM 20259 / NCIMB 9735 / NBRC 12172Imported.

Entry informationi

Entry nameiG4L2G2_TETHN
AccessioniPrimary (citable) accession number: G4L2G2
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 22, 2015
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.