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G4KVE1 (G4KVE1_OSCVS) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108
EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Name:icd EMBL BAL00574.1
Ordered Locus Names:OBV_33750 EMBL BAL00574.1
OrganismOscillibacter valericigenes (strain DSM 18026 / NBRC 101213 / Sjm18-20) [Complete proteome] [HAMAP]
Taxonomic identifier693746 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Clostridia › Clostridiales › Oscillospiraceae › Oscillibacter ›

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRSR PIRSR000108-3 PIRNR PIRNR000108

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2731Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
G4KVE1 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: A9DEA7E3455DAA42

FASTA40946,272
        10         20         30         40         50         60 
MEKIKMKVPL VEMDGDEMTR ILWRIIREDL IEPYVDLKTE YYDLSLRHRD ETRDQVTVDA 

        70         80         90        100        110        120 
ANATERLGVA VKCATITANR QRQEEYHLSE IWPSPNGTIR AVLDGTAFRA PILLPFLRPA 

       130        140        150        160        170        180 
VPGWEKPITV ARHAYGDMYK AVELVTDEPG VATLNFKGQS GREQTLTIAR TKGSAVFQGQ 

       190        200        210        220        230        240 
HNTETSIRAF VHSCFQYALD TKQDLWFSAK DTISKEYDGE FRRAFDEEFA NTYKDKFDTL 

       250        260        270        280        290        300 
GLHYFYTLID DAVSRVMRSK GGFIWALKNY DGDVMSDMVA AAFGSLAMMT SVLMAPDGSM 

       310        320        330        340        350        360 
EFEASHGTVT RHFYRYRAGE KPSTNSTATI FAWTGALRRR GQLDDLPDLV SFAGKLESAC 

       370        380        390        400 
LETMKDGLLT GDLAVLVDEG HRCQIVNYEE SLRAISKRLA EKMRTVSER

« Hide

References

[1]"Whole genome sequence of Oscillibacter valericigenes Sjm18-20."
Katano Y., Fujinami S., Kawakoshi A., Ohji S., Nakazawa H., Ankai A., Oguchi A., Fukui S., Terui Y., Harada T., Takahashi M., Suzuki K., Fujita N.
Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 18026 / NBRC 101213 / Sjm18-20.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AP012044 Genomic DNA. Translation: BAL00574.1.
RefSeqYP_004883079.1. NC_016048.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAL00574; BAL00574; OBV_33750.
GeneID11237561.
KEGGova:OBV_33750.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00031.

Enzyme and pathway databases

BioCycOVAL693746:GJWX-3421-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG4KVE1_OSCVS
AccessionPrimary (citable) accession number: G4KVE1
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 3, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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