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G4KVE1

- G4KVE1_OSCVS

UniProt

G4KVE1 - G4KVE1_OSCVS

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Oscillibacter valericigenes (strain DSM 18026 / NBRC 101213 / Sjm18-20)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771Substrate
    Binding sitei109 – 1091Substrate
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei210 – 2101Critical for catalysisUniRule annotation
    Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
    Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciOVAL693746:GJWX-3421-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:OBV_33750Imported
    OrganismiOscillibacter valericigenes (strain DSM 18026 / NBRC 101213 / Sjm18-20)Imported
    Taxonomic identifieri693746 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesOscillospiraceaeOscillibacter
    ProteomesiUP000005219: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G4KVE1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKIKMKVPL VEMDGDEMTR ILWRIIREDL IEPYVDLKTE YYDLSLRHRD    50
    ETRDQVTVDA ANATERLGVA VKCATITANR QRQEEYHLSE IWPSPNGTIR 100
    AVLDGTAFRA PILLPFLRPA VPGWEKPITV ARHAYGDMYK AVELVTDEPG 150
    VATLNFKGQS GREQTLTIAR TKGSAVFQGQ HNTETSIRAF VHSCFQYALD 200
    TKQDLWFSAK DTISKEYDGE FRRAFDEEFA NTYKDKFDTL GLHYFYTLID 250
    DAVSRVMRSK GGFIWALKNY DGDVMSDMVA AAFGSLAMMT SVLMAPDGSM 300
    EFEASHGTVT RHFYRYRAGE KPSTNSTATI FAWTGALRRR GQLDDLPDLV 350
    SFAGKLESAC LETMKDGLLT GDLAVLVDEG HRCQIVNYEE SLRAISKRLA 400
    EKMRTVSER 409
    Length:409
    Mass (Da):46,272
    Last modified:December 14, 2011 - v1
    Checksum:iA9DEA7E3455DAA42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012044 Genomic DNA. Translation: BAL00574.1.
    RefSeqiYP_004883079.1. NC_016048.1.

    Genome annotation databases

    EnsemblBacteriaiBAL00574; BAL00574; OBV_33750.
    GeneIDi11237561.
    KEGGiova:OBV_33750.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012044 Genomic DNA. Translation: BAL00574.1 .
    RefSeqi YP_004883079.1. NC_016048.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAL00574 ; BAL00574 ; OBV_33750 .
    GeneIDi 11237561.
    KEGGi ova:OBV_33750.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci OVAL693746:GJWX-3421-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole genome sequence of Oscillibacter valericigenes Sjm18-20."
      Katano Y., Fujinami S., Kawakoshi A., Ohji S., Nakazawa H., Ankai A., Oguchi A., Fukui S., Terui Y., Harada T., Takahashi M., Suzuki K., Fujita N.
      Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 18026 / NBRC 101213 / Sjm18-20Imported.

    Entry informationi

    Entry nameiG4KVE1_OSCVS
    AccessioniPrimary (citable) accession number: G4KVE1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3