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G4KVE1

- G4KVE1_OSCVS

UniProt

G4KVE1 - G4KVE1_OSCVS

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Protein

Isocitrate dehydrogenase [NADP]

Gene
icd, OBV_33750
Organism
Oscillibacter valericigenes (strain DSM 18026 / NBRC 101213 / Sjm18-20)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771Substrate By similarityUniRule annotation
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei132 – 1321Substrate By similarityUniRule annotation
Sitei139 – 1391Critical for catalysis By similarityUniRule annotation
Sitei210 – 2101Critical for catalysis By similarityUniRule annotation
Metal bindingi250 – 2501Magnesium or manganese By similarityUniRule annotation
Metal bindingi273 – 2731Magnesium or manganese By similarityUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciOVAL693746:GJWX-3421-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:OBV_33750Imported
OrganismiOscillibacter valericigenes (strain DSM 18026 / NBRC 101213 / Sjm18-20)Imported
Taxonomic identifieri693746 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesOscillospiraceaeOscillibacter
ProteomesiUP000005219: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4KVE1-1 [UniParc]FASTAAdd to Basket

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MEKIKMKVPL VEMDGDEMTR ILWRIIREDL IEPYVDLKTE YYDLSLRHRD    50
ETRDQVTVDA ANATERLGVA VKCATITANR QRQEEYHLSE IWPSPNGTIR 100
AVLDGTAFRA PILLPFLRPA VPGWEKPITV ARHAYGDMYK AVELVTDEPG 150
VATLNFKGQS GREQTLTIAR TKGSAVFQGQ HNTETSIRAF VHSCFQYALD 200
TKQDLWFSAK DTISKEYDGE FRRAFDEEFA NTYKDKFDTL GLHYFYTLID 250
DAVSRVMRSK GGFIWALKNY DGDVMSDMVA AAFGSLAMMT SVLMAPDGSM 300
EFEASHGTVT RHFYRYRAGE KPSTNSTATI FAWTGALRRR GQLDDLPDLV 350
SFAGKLESAC LETMKDGLLT GDLAVLVDEG HRCQIVNYEE SLRAISKRLA 400
EKMRTVSER 409
Length:409
Mass (Da):46,272
Last modified:December 14, 2011 - v1
Checksum:iA9DEA7E3455DAA42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012044 Genomic DNA. Translation: BAL00574.1.
RefSeqiYP_004883079.1. NC_016048.1.

Genome annotation databases

EnsemblBacteriaiBAL00574; BAL00574; OBV_33750.
GeneIDi11237561.
KEGGiova:OBV_33750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012044 Genomic DNA. Translation: BAL00574.1 .
RefSeqi YP_004883079.1. NC_016048.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAL00574 ; BAL00574 ; OBV_33750 .
GeneIDi 11237561.
KEGGi ova:OBV_33750.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci OVAL693746:GJWX-3421-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Oscillibacter valericigenes Sjm18-20."
    Katano Y., Fujinami S., Kawakoshi A., Ohji S., Nakazawa H., Ankai A., Oguchi A., Fukui S., Terui Y., Harada T., Takahashi M., Suzuki K., Fujita N.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18026 / NBRC 101213 / Sjm18-20.

Entry informationi

Entry nameiG4KVE1_OSCVS
AccessioniPrimary (citable) accession number: G4KVE1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 9, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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