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G4KVE1

- G4KVE1_OSCVS

UniProt

G4KVE1 - G4KVE1_OSCVS

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Oscillibacter valericigenes (strain DSM 18026 / NBRC 101213 / Sjm18-20)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei210 – 2101Critical for catalysisUniRule annotation
Metal bindingi250 – 2501Magnesium or manganeseUniRule annotation
Metal bindingi273 – 2731Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciOVAL693746:GJWX-3421-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:OBV_33750Imported
OrganismiOscillibacter valericigenes (strain DSM 18026 / NBRC 101213 / Sjm18-20)Imported
Taxonomic identifieri693746 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesOscillospiraceaeOscillibacter
ProteomesiUP000005219: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G4KVE1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKIKMKVPL VEMDGDEMTR ILWRIIREDL IEPYVDLKTE YYDLSLRHRD
60 70 80 90 100
ETRDQVTVDA ANATERLGVA VKCATITANR QRQEEYHLSE IWPSPNGTIR
110 120 130 140 150
AVLDGTAFRA PILLPFLRPA VPGWEKPITV ARHAYGDMYK AVELVTDEPG
160 170 180 190 200
VATLNFKGQS GREQTLTIAR TKGSAVFQGQ HNTETSIRAF VHSCFQYALD
210 220 230 240 250
TKQDLWFSAK DTISKEYDGE FRRAFDEEFA NTYKDKFDTL GLHYFYTLID
260 270 280 290 300
DAVSRVMRSK GGFIWALKNY DGDVMSDMVA AAFGSLAMMT SVLMAPDGSM
310 320 330 340 350
EFEASHGTVT RHFYRYRAGE KPSTNSTATI FAWTGALRRR GQLDDLPDLV
360 370 380 390 400
SFAGKLESAC LETMKDGLLT GDLAVLVDEG HRCQIVNYEE SLRAISKRLA

EKMRTVSER
Length:409
Mass (Da):46,272
Last modified:December 14, 2011 - v1
Checksum:iA9DEA7E3455DAA42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012044 Genomic DNA. Translation: BAL00574.1.
RefSeqiWP_014119190.1. NC_016048.1.
YP_004883079.1. NC_016048.1.

Genome annotation databases

EnsemblBacteriaiBAL00574; BAL00574; OBV_33750.
GeneIDi11237561.
KEGGiova:OBV_33750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012044 Genomic DNA. Translation: BAL00574.1 .
RefSeqi WP_014119190.1. NC_016048.1.
YP_004883079.1. NC_016048.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAL00574 ; BAL00574 ; OBV_33750 .
GeneIDi 11237561.
KEGGi ova:OBV_33750.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci OVAL693746:GJWX-3421-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole genome sequence of Oscillibacter valericigenes Sjm18-20."
    Katano Y., Fujinami S., Kawakoshi A., Ohji S., Nakazawa H., Ankai A., Oguchi A., Fukui S., Terui Y., Harada T., Takahashi M., Suzuki K., Fujita N.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 18026 / NBRC 101213 / Sjm18-20Imported.

Entry informationi

Entry nameiG4KVE1_OSCVS
AccessioniPrimary (citable) accession number: G4KVE1
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 26, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3