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G4FFF4

- G4FFF4_THEMA

UniProt

G4FFF4 - G4FFF4_THEMA

Protein
Submitted name:

CTP:Inositol-1-phosphate cytidylyltransferase / Phospho-di-inositol-1-phosphate synthase

Gene

THEMA_07220

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei122 – 1221Phosphate 1Imported
    Metal bindingi131 – 1311SodiumImported
    Binding sitei192 – 1921Phosphate 2Imported
    Binding sitei193 – 1931Phosphate 3Imported
    Binding sitei197 – 1971Phosphate 3Imported
    Binding sitei207 – 2071Phosphate 1; via carbonyl oxygenImported
    Metal bindingi210 – 2101SodiumImported
    Metal bindingi211 – 2111Sodium; via carbonyl oxygenImported
    Metal bindingi213 – 2131Sodium; via carbonyl oxygenImported

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleotidyltransferase activity Source: UniProtKB-KW

    GO - Biological processi

    1. biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    NucleotidyltransferaseImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CTP:Inositol-1-phosphate cytidylyltransferase / Phospho-di-inositol-1-phosphate synthaseImported (EC:2.7.8.-Imported)
    Submitted name:
    Nucleotidyl transferaseImported
    Gene namesi
    ORF Names:THEMA_07220Imported, Tmari_1425Imported
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4JD0X-ray1.80A1-241[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni157 – 1582Phosphate 2 bindingImported

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    InterProiIPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PfamiPF00483. NTP_transferase. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G4FFF4-1 [UniParc]FASTAAdd to Basket

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    MREAIVLASG AGKRLRSVTG DVPKVFYRFD GCELVKYPMI SLMKNGVERF    50
    VLVVSEGYRD LGEKVLNDLG VEGIVVENKK VELGNAYSFF LSEPYVESEK 100
    FFLSCGDSLF PPEALKSAFS EDEFHIKLGV SKRSDLIDPE EASKVLVNED 150
    RIVKIGKRID EYNYFDTGVF VMTKKVYSLK ESFSWTEEIS LYHVLQKAVD 200
    TGMIVKVFDF GNALWTEIDS PEDLNEKVYE LMKKIKEGVA C 241
    Length:241
    Mass (Da):27,323
    Last modified:December 14, 2011 - v1
    Checksum:i8153E6A8592ECF10
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP004077 Genomic DNA. Translation: AGL50349.1.
    CP007013 Genomic DNA. Translation: AHD18687.1.
    RefSeqiYP_007977774.1. NC_021214.1.
    YP_008991491.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAGL50349; AGL50349; Tmari_1425.
    KEGGitmi:THEMA_07220.
    tmm:Tmari_1425.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP004077 Genomic DNA. Translation: AGL50349.1 .
    CP007013 Genomic DNA. Translation: AHD18687.1 .
    RefSeqi YP_007977774.1. NC_021214.1.
    YP_008991491.1. NC_023151.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4JD0 X-ray 1.80 A 1-241 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AGL50349 ; AGL50349 ; Tmari_1425 .
    KEGGi tmi:THEMA_07220.
    tmm:Tmari_1425.

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    InterProi IPR005835. NTP_transferase.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    Pfami PF00483. NTP_transferase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure of the inositol-1-phosphate cytidylyltransferase from Thermotoga maritima."
      Kurnasov O.V., Luk H.J., Roberts M.F., Stec B.
      Acta Crystallogr. D 69:1808-1817(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS).
    2. "The genome organization of Thermotoga maritima reflects its lifestyle."
      Latif H., Lerman J.A., Portnoy V.A., Tarasova Y., Nagarajan H., Schrimpe-Rutledge A.C., Smith R.D., Adkins J.N., Lee D.H., Qiu Y., Zengler K.
      PLoS Genet. 9:E1003485-E1003485(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MSB8Imported.

    Entry informationi

    Entry nameiG4FFF4_THEMA
    AccessioniPrimary (citable) accession number: G4FFF4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 16 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3