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G4FD89 (G4FD89_THEMA) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 13. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO HAMAP-Rule MF_01037
EC=2.1.1.74 HAMAP-Rule MF_01037
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase HAMAP-Rule MF_01037
Folate-dependent tRNA(M-5-U54)-methyltransferase HAMAP-Rule MF_01037
Gene names
Name:trmFO HAMAP-Rule MF_01037
ORF Names:ThemaDRAFT_0567 EMBL EHA61324.1
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) EMBL EHA61324.1
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga ›

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity. HAMAP-Rule MF_01037 SAAS SAAS004417

Catalytic activity

5,10-methylenetetrahydrofolate + uridine54 in tRNA + FADH2 = tetrahydrofolate + 5-methyluridine54 in tRNA + FAD. HAMAP-Rule MF_01037 SAAS SAAS004417

Cofactor

FAD By similarity. HAMAP-Rule MF_01037 SAAS SAAS004417

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01037.

Sequence similarities

Belongs to the MnmG family. TrmFO subfamily. HAMAP-Rule MF_01037

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data. EMBL EHA61324.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding7 – 126FAD By similarity HAMAP-Rule MF_01037

Sequences

Sequence LengthMass (Da)Tools
G4FD89 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: 768BFBAB0C97D57F

FASTA43549,689
        10         20         30         40         50         60 
MIVNVIGAGL AGSEVAYNLG KRGIRVRLFE MRPKKMTEVH KTGYFAELVC SNSLKSEDIT 

        70         80         90        100        110        120 
NAEGLLKAEM RLMGSITLEA AEKARVPSGK ALAVDRNIFA KEVTEVIERL ESVEIIREEV 

       130        140        150        160        170        180 
TEFDPEEGIW VVATGPATSD GLLPFLKKLL GDDLLFFFDA VSPIVTFESI DMECAFWGDR 

       190        200        210        220        230        240 
FGKGKDYINC PLTKEEYEEF WKALVEAEVI EMEDFDRKLL FERCQPIEEI ARSGKDALRY 

       250        260        270        280        290        300 
GPLRPTGLVD PRTGKEPYAV VQLRREDKEG RFYSLVGFQT RLKWSEQKRV LRKIPCLRNA 

       310        320        330        340        350        360 
EIVRYGVMHR NVYINSPKLL DIFFRLKKHP NIFFAGQITG VEGYMESAAS GIYVAYNVHR 

       370        380        390        400        410        420 
ILKGLSPLKL PEETMMGALF SYIIEKVEGD LKPMYANFGL LPPLKVRVKD KFEKRKKLAE 

       430 
RAIETMKKFL EENPW

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References

[1]"The draft genome of Thermotoga maritima MSB8."
US DOE Joint Genome Institute (JGI-PGF)
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Land M.L., Hauser L., Boucher N., Noll K., Woyke T.
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MSB8 EMBL EHA61324.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AGIJ01000001 Genomic DNA. Translation: EHA61324.1.
RefSeqNP_228543.1. NC_000853.1.

3D structure databases

ProteinModelPortalG4FD89.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEHA61324; EHA61324; ThemaDRAFT_0567.
GeneID898401.
KEGGtma:TM0734.

Phylogenomic databases

KOK04094.
OMARFAGQIT.

Family and domain databases

HAMAPMF_01037. TrmFO.
InterProIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
[Graphical view]
PfamPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00137. gid_trmFO. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG4FD89_THEMA
AccessionPrimary (citable) accession number: G4FD89
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 3, 2013
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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