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G4FD89

- G4FD89_THEMA

UniProt

G4FD89 - G4FD89_THEMA

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

gid

Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (14 Dec 2011)
      Previous versions | rss
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    Functioni

    Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotationSAAS annotation

    Catalytic activityi

    5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotation

    Cofactori

    FAD.UniRule annotationSAAS annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126FADUniRule annotation

    GO - Molecular functioni

    1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
    2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
    3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    tRNA processingUniRule annotationSAAS annotation

    Keywords - Ligandi

    FADUniRule annotationSAAS annotation, Flavoprotein

    Enzyme and pathway databases

    BioCyciTMAR243274:GC6P-760-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
    Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
    Gene namesi
    Name:gidImported
    Synonyms:trmFOUniRule annotation
    ORF Names:THEMA_00985Imported, Tmari_0735Imported
    OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
    Taxonomic identifieri243274 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

    Phylogenomic databases

    KOiK04094.
    OMAiEIYFEGC.

    Family and domain databases

    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    G4FD89-1 [UniParc]FASTAAdd to Basket

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    MIVNVIGAGL AGSEVAYNLG KRGIRVRLFE MRPKKMTEVH KTGYFAELVC    50
    SNSLKSEDIT NAEGLLKAEM RLMGSITLEA AEKARVPSGK ALAVDRNIFA 100
    KEVTEVIERL ESVEIIREEV TEFDPEEGIW VVATGPATSD GLLPFLKKLL 150
    GDDLLFFFDA VSPIVTFESI DMECAFWGDR FGKGKDYINC PLTKEEYEEF 200
    WKALVEAEVI EMEDFDRKLL FERCQPIEEI ARSGKDALRY GPLRPTGLVD 250
    PRTGKEPYAV VQLRREDKEG RFYSLVGFQT RLKWSEQKRV LRKIPCLRNA 300
    EIVRYGVMHR NVYINSPKLL DIFFRLKKHP NIFFAGQITG VEGYMESAAS 350
    GIYVAYNVHR ILKGLSPLKL PEETMMGALF SYIIEKVEGD LKPMYANFGL 400
    LPPLKVRVKD KFEKRKKLAE RAIETMKKFL EENPW 435
    Length:435
    Mass (Da):49,689
    Last modified:December 14, 2011 - v1
    Checksum:i768BFBAB0C97D57F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP004077 Genomic DNA. Translation: AGL49660.1.
    CP007013 Genomic DNA. Translation: AHD17511.1.
    RefSeqiNP_228543.1. NC_000853.1.
    YP_007977085.1. NC_021214.1.
    YP_008990296.1. NC_023151.1.

    Genome annotation databases

    EnsemblBacteriaiAGL49660; AGL49660; Tmari_0735.
    GeneIDi898401.
    KEGGitma:TM0734.
    tmi:THEMA_00985.
    tmm:Tmari_0735.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP004077 Genomic DNA. Translation: AGL49660.1 .
    CP007013 Genomic DNA. Translation: AHD17511.1 .
    RefSeqi NP_228543.1. NC_000853.1.
    YP_007977085.1. NC_021214.1.
    YP_008990296.1. NC_023151.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AGL49660 ; AGL49660 ; Tmari_0735 .
    GeneIDi 898401.
    KEGGi tma:TM0734.
    tmi:THEMA_00985.
    tmm:Tmari_0735.

    Phylogenomic databases

    KOi K04094.
    OMAi EIYFEGC.

    Enzyme and pathway databases

    BioCyci TMAR243274:GC6P-760-MONOMER.

    Family and domain databases

    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome organization of Thermotoga maritima reflects its lifestyle."
      Latif H., Lerman J.A., Portnoy V.A., Tarasova Y., Nagarajan H., Schrimpe-Rutledge A.C., Smith R.D., Adkins J.N., Lee D.H., Qiu Y., Zengler K.
      PLoS Genet. 9:E1003485-E1003485(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099Imported and MSB8Imported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MSB8Imported.

    Entry informationi

    Entry nameiG4FD89_THEMA
    AccessioniPrimary (citable) accession number: G4FD89
    Entry historyi
    Integrated into UniProtKB/TrEMBL: December 14, 2011
    Last sequence update: December 14, 2011
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)