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G4FD89 (G4FD89_THEMA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO HAMAP-Rule MF_01037

EC=2.1.1.74 HAMAP-Rule MF_01037
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase HAMAP-Rule MF_01037
Folate-dependent tRNA(M-5-U54)-methyltransferase HAMAP-Rule MF_01037
Gene names
Name:gid EMBL AHD17511.1
Synonyms:trmFO HAMAP-Rule MF_01037
ORF Names:THEMA_00985 EMBL AHD17511.1, Tmari_0735 EMBL AGL49660.1
OrganismThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) EMBL AHD17511.1
Taxonomic identifier243274 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity. SAAS SAAS004417 HAMAP-Rule MF_01037

Catalytic activity

5,10-methylenetetrahydrofolate + uracil54 in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil54 in tRNA + FAD. SAAS SAAS004417 HAMAP-Rule MF_01037

Cofactor

FAD By similarity. SAAS SAAS004417 HAMAP-Rule MF_01037

Subcellular location

Cytoplasm By similarity SAAS SAAS004417 HAMAP-Rule MF_01037.

Sequence similarities

Belongs to the MnmG family. TrmFO subfamily. HAMAP-Rule MF_01037

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding7 – 126FAD By similarity HAMAP-Rule MF_01037

Sequences

Sequence LengthMass (Da)Tools
G4FD89 [UniParc].

Last modified December 14, 2011. Version 1.
Checksum: 768BFBAB0C97D57F

FASTA43549,689
        10         20         30         40         50         60 
MIVNVIGAGL AGSEVAYNLG KRGIRVRLFE MRPKKMTEVH KTGYFAELVC SNSLKSEDIT 

        70         80         90        100        110        120 
NAEGLLKAEM RLMGSITLEA AEKARVPSGK ALAVDRNIFA KEVTEVIERL ESVEIIREEV 

       130        140        150        160        170        180 
TEFDPEEGIW VVATGPATSD GLLPFLKKLL GDDLLFFFDA VSPIVTFESI DMECAFWGDR 

       190        200        210        220        230        240 
FGKGKDYINC PLTKEEYEEF WKALVEAEVI EMEDFDRKLL FERCQPIEEI ARSGKDALRY 

       250        260        270        280        290        300 
GPLRPTGLVD PRTGKEPYAV VQLRREDKEG RFYSLVGFQT RLKWSEQKRV LRKIPCLRNA 

       310        320        330        340        350        360 
EIVRYGVMHR NVYINSPKLL DIFFRLKKHP NIFFAGQITG VEGYMESAAS GIYVAYNVHR 

       370        380        390        400        410        420 
ILKGLSPLKL PEETMMGALF SYIIEKVEGD LKPMYANFGL LPPLKVRVKD KFEKRKKLAE 

       430 
RAIETMKKFL EENPW 

« Hide

References

« Hide 'large scale' references
[1]"The genome organization of Thermotoga maritima reflects its lifestyle."
Latif H., Lerman J.A., Portnoy V.A., Tarasova Y., Nagarajan H., Schrimpe-Rutledge A.C., Smith R.D., Adkins J.N., Lee D.H., Qiu Y., Zengler K.
PLoS Genet. 9:E1003485-E1003485(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099 and MSB8 EMBL AGL49660.1.
[2]DOE Joint Genome Institute
Noll K.M., Huntemann M., Han J., Chen A., Kyrpides N., Mavromatis K., Markowitz V., Palaniappan K., Ivanova N., Schaumberg A., Pati A., Liolios K., Nordberg H.P., Cantor M.N., Hua S.X., Woyke T.
Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MSB8 EMBL AHD17511.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP004077 Genomic DNA. Translation: AGL49660.1.
CP007013 Genomic DNA. Translation: AHD17511.1.
RefSeqNP_228543.1. NC_000853.1.
YP_007977085.1. NC_021214.1.
YP_008990296.1. NC_023151.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAGL49660; AGL49660; Tmari_0735.
EHA61324; EHA61324; ThemaDRAFT_0567.
GeneID15494338.
18092053.
898401.
KEGGtma:TM0734.
tmm:Tmari_0735.

Phylogenomic databases

KOK04094.
OMARFAGQIT.

Enzyme and pathway databases

BioCycTMAR243274:GC6P-760-MONOMER.

Family and domain databases

HAMAPMF_01037. TrmFO.
InterProIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
[Graphical view]
PfamPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00137. gid_trmFO. 1 hit.
ProtoNetSearch...

Entry information

Entry nameG4FD89_THEMA
AccessionPrimary (citable) accession number: G4FD89
Entry history
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 16, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)