SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

G4FD89

- G4FD89_THEMA

UniProt

G4FD89 - G4FD89_THEMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene
gid, trmFO, THEMA_00985, Tmari_0735
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity.UniRule annotationSAAS annotations

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotationSAAS annotations

Cofactori

FAD By similarity.UniRule annotationSAAS annotations

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126FAD By similarityUniRule annotation

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

tRNA processingUniRule annotationSAAS annotations

Keywords - Ligandi

FADUniRule annotationSAAS annotations, Flavoprotein

Enzyme and pathway databases

BioCyciTMAR243274:GC6P-760-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferase
Folate-dependent tRNA(M-5-U54)-methyltransferase
Gene namesi
Name:gidImported
Synonyms:trmFOUniRule annotation
ORF Names:THEMA_00985Imported, Tmari_0735Imported
OrganismiThermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)Imported
Taxonomic identifieri243274 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

KOiK04094.
OMAiEIYFEGC.

Family and domain databases

HAMAPiMF_01037. TrmFO.
InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
[Graphical view]
PfamiPF01134. GIDA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

Sequencei

Sequence statusi: Complete.

G4FD89-1 [UniParc]FASTAAdd to Basket

« Hide

MIVNVIGAGL AGSEVAYNLG KRGIRVRLFE MRPKKMTEVH KTGYFAELVC    50
SNSLKSEDIT NAEGLLKAEM RLMGSITLEA AEKARVPSGK ALAVDRNIFA 100
KEVTEVIERL ESVEIIREEV TEFDPEEGIW VVATGPATSD GLLPFLKKLL 150
GDDLLFFFDA VSPIVTFESI DMECAFWGDR FGKGKDYINC PLTKEEYEEF 200
WKALVEAEVI EMEDFDRKLL FERCQPIEEI ARSGKDALRY GPLRPTGLVD 250
PRTGKEPYAV VQLRREDKEG RFYSLVGFQT RLKWSEQKRV LRKIPCLRNA 300
EIVRYGVMHR NVYINSPKLL DIFFRLKKHP NIFFAGQITG VEGYMESAAS 350
GIYVAYNVHR ILKGLSPLKL PEETMMGALF SYIIEKVEGD LKPMYANFGL 400
LPPLKVRVKD KFEKRKKLAE RAIETMKKFL EENPW 435
Length:435
Mass (Da):49,689
Last modified:December 14, 2011 - v1
Checksum:i768BFBAB0C97D57F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004077 Genomic DNA. Translation: AGL49660.1.
CP007013 Genomic DNA. Translation: AHD17511.1.
RefSeqiNP_228543.1. NC_000853.1.
YP_007977085.1. NC_021214.1.
YP_008990296.1. NC_023151.1.

Genome annotation databases

EnsemblBacteriaiAGL49660; AGL49660; Tmari_0735.
GeneIDi898401.
KEGGitma:TM0734.
tmi:THEMA_00985.
tmm:Tmari_0735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP004077 Genomic DNA. Translation: AGL49660.1 .
CP007013 Genomic DNA. Translation: AHD17511.1 .
RefSeqi NP_228543.1. NC_000853.1.
YP_007977085.1. NC_021214.1.
YP_008990296.1. NC_023151.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AGL49660 ; AGL49660 ; Tmari_0735 .
GeneIDi 898401.
KEGGi tma:TM0734.
tmi:THEMA_00985.
tmm:Tmari_0735.

Phylogenomic databases

KOi K04094.
OMAi EIYFEGC.

Enzyme and pathway databases

BioCyci TMAR243274:GC6P-760-MONOMER.

Family and domain databases

HAMAPi MF_01037. TrmFO.
InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
IPR002218. GIDA-rel.
[Graphical view ]
Pfami PF01134. GIDA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome organization of Thermotoga maritima reflects its lifestyle."
    Latif H., Lerman J.A., Portnoy V.A., Tarasova Y., Nagarajan H., Schrimpe-Rutledge A.C., Smith R.D., Adkins J.N., Lee D.H., Qiu Y., Zengler K.
    PLoS Genet. 9:E1003485-E1003485(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 43589 / MSB8 / DSM 3109 / JCM 10099 and MSB8Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MSB8Imported.

Entry informationi

Entry nameiG4FD89_THEMA
AccessioniPrimary (citable) accession number: G4FD89
Entry historyi
Integrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi