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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha

Gene

accA

Organism
Bacillus subtilis subsp. subtilis str. SC-8
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.UniRule annotationSAAS annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotationSAAS annotation

Pathwayi: malonyl-CoA biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha (accA), Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (accD)
This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported, TransferaseImported
Biological processFatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit alphaUniRule annotationSAAS annotation (EC:6.4.1.2UniRule annotationSAAS annotation)
Short name:
ACCase subunit alphaUniRule annotation
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit alphaUniRule annotation
Gene namesi
Name:accAUniRule annotation
ORF Names:BSSC8_13200Imported
OrganismiBacillus subtilis subsp. subtilis str. SC-8Imported
Taxonomic identifieri1089443 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000004759 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliG4ESJ0.
SMRiG4ESJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 292CoA carboxyltransferase C-terminalInterPro annotationAdd BLAST255

Sequence similaritiesi

Belongs to the AccA family.UniRule annotationSAAS annotation

Family and domain databases

HAMAPiMF_00823. AcetylCoA_CT_alpha. 1 hit.
InterProiView protein in InterPro
IPR001095. Acetyl_CoA_COase_a_su.
IPR029045. ClpP/crotonase-like_dom_sf.
IPR011763. COA_CT_C.
PANTHERiPTHR42853. PTHR42853. 1 hit.
PfamiView protein in Pfam
PF03255. ACCA. 1 hit.
PRINTSiPR01069. ACCCTRFRASEA.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00513. accA. 1 hit.
PROSITEiView protein in PROSITE
PS50989. COA_CT_CTER. 1 hit.

Sequencei

Sequence statusi: Complete.

G4ESJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPRLEFEKP VIELQTKIAE LKKFTQDSDM DLSAEIERLE DRLAKLQDDI
60 70 80 90 100
YKNLKPWDRV QIARLADRPT TLDYIEHLFT DFFECHGDRA YGDDEAIVGG
110 120 130 140 150
IAKFHGLPVT VIGHQRGKDT KENLVRNFGM PHPEGYRKAL RLMKQADKFN
160 170 180 190 200
RPIICFIDTK GAYPGRAAEE RGQSEAIAKN LFEMAGLRVP VICIVIGEGG
210 220 230 240 250
SGGALGLGVG NHLHMLENST YSVISPEGAA ALLWKDSSLA KKAAETMKIT
260 270 280 290 300
APDLKELGII DHMIKEVKGG AHHDVKLQAS YMDETLKQSL KTLLKLSEEE
310 320
LVQQRYEKYK AIGKVSVEDQ YIGVN
Length:325
Mass (Da):36,334
Last modified:December 14, 2011 - v1
Checksum:i9B177DEE4A5B5864
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGFW01000003 Genomic DNA. Translation: EHA30877.1.
RefSeqiWP_003229417.1. NZ_AGFW01000003.1.

Genome annotation databases

EnsemblBacteriaiEHA30877; EHA30877; BSSC8_13200.
PATRICifig|1089443.3.peg.1333.

Similar proteinsi

Entry informationi

Entry nameiG4ESJ0_BACIU
AccessioniPrimary (citable) accession number: G4ESJ0
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: November 22, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported