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Protein

Histidine ammonia-lyase

Gene

hutH

Organism
Bacillus subtilis subsp. subtilis str. SC-8
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidine = urocanate + NH3.UniRule annotationSAAS annotation

Pathwayi: L-histidine degradation into L-glutamate

This protein is involved in step 1 of the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Histidine ammonia-lyase (hutH)
  2. Urocanate hydratase (hutU)
  3. Imidazolonepropionase (hutI)
This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N-formimidoyl-L-glutamate from L-histidine, the pathway L-histidine degradation into L-glutamate and in Amino-acid degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processHistidine metabolismUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00379; UER00549.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine ammonia-lyaseUniRule annotationSAAS annotation (EC:4.3.1.3UniRule annotationSAAS annotation)
Short name:
HistidaseUniRule annotation
Gene namesi
Name:hutHUniRule annotation
ORF Names:BSSC8_02490Imported
OrganismiBacillus subtilis subsp. subtilis str. SC-8Imported
Taxonomic identifieri1089443 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000004759 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki153 ↔ 1555-imidazolinone (Ala-Gly)UniRule annotation
Modified residuei1542,3-didehydroalanine (Ser)UniRule annotation1

Post-translational modificationi

Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.UniRule annotation
Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ser-Ser-Gly.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliG4EPG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PAL/histidase family.UniRule annotationSAAS annotation

Family and domain databases

CDDicd00332. PAL-HAL. 1 hit.
Gene3Di1.10.275.10. 1 hit.
HAMAPiMF_00229. His_ammonia_lyase. 1 hit.
InterProiView protein in InterPro
IPR001106. Aromatic_Lyase.
IPR024083. Fumarase/histidase_N.
IPR005921. HutH.
IPR008948. L-Aspartase-like.
IPR022313. Phe/His_NH3-lyase_AS.
PANTHERiPTHR10362. PTHR10362. 1 hit.
PfamiView protein in Pfam
PF00221. Lyase_aromatic. 1 hit.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR01225. hutH. 1 hit.
PROSITEiView protein in PROSITE
PS00488. PAL_HISTIDASE. 1 hit.

Sequencei

Sequence statusi: Complete.

G4EPG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYQSKEKGV GLMVTLDGSS LTTADVARVL FDFEEAAASE ESMERVKKSR
60 70 80 90 100
AAVERIVRDE KTIYGINTGF GKFSDVLIQK EDSAALQLNL ILSHACGVGD
110 120 130 140 150
PFPECVSRAM LLLRANALLK GFSGVRAELI EQLLAFLNKR VHPVIPQQGS
160 170 180 190 200
LGASGDLAPL SHLALALIGQ GEVFFEGERM PAMTGLKKAG IQPVTLTSKE
210 220 230 240 250
GLALINGTQA MTAMGVVAYI EAEKLAYQTE RIASLTIEGL RGIIDAFDED
260 270 280 290 300
IHSARGYQEQ IDVAERIRFY LSNSGLTTSQ GELRVQDAYS LRCIPQVHGA
310 320 330 340 350
TWQTLGYVKE KLEIEMNAAT DNPLIFNDGD KVISGGNFHG QPIAFAMDFL
360 370 380 390 400
KIAISELANI AERRIERLVN PQLNDLPPFL SPHPGLQSGA MIMQYAAASL
410 420 430 440 450
VSENKTLAHP ASVDSIPSSA NQEDHVSMGT IAARHAYQVI ANTRRVIAIE
460 470 480 490 500
AICALQAVEY RGIEHAASYT KQLFQEMRKV VPSIQQDRVF SYDIERLTDW
510 520
LKKESLIPDH QNKELRGMNI
Length:520
Mass (Da):57,010
Last modified:December 14, 2011 - v1
Checksum:i44EA0C96E5E3648B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AGFW01000001 Genomic DNA. Translation: EHA31992.1.

Genome annotation databases

EnsemblBacteriaiEHA31992; EHA31992; BSSC8_02490.
PATRICifig|1089443.3.peg.255.

Similar proteinsi

Entry informationi

Entry nameiG4EPG9_BACIU
AccessioniPrimary (citable) accession number: G4EPG9
Entry historyiIntegrated into UniProtKB/TrEMBL: December 14, 2011
Last sequence update: December 14, 2011
Last modified: March 28, 2018
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported