G3XDD8 (LYG_DRONO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Lysozyme G EC=3.2.1.17 Alternative name(s): 1,4-beta-N-acetylmuramidase
Organism	Dromaius novaehollandiae (Emu)
Taxonomic identifier	8790 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Palaeognathae › Casuariiformes › Dromaiidae › Dromaius

Protein attributes

Sequence length	204 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has bacteriolytic activity against M.luteus. Ref.1
Catalytic activity	Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. UniProtKB Q90X99
Subcellular location	Secreted By similarity UniProtKB Q90X99.
Sequence similarities	Belongs to the glycosyl hydrolase 23 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Antimicrobial Bacteriolytic enzyme Glycosidase Hydrolase
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro cytolysis Inferred from electronic annotation. Source: UniProtKB-KW defense response to bacterium Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	lysozyme activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 204	185	Lysozyme G		PRO_5000795990
Sites
	Active site	92	1	By similarity UniProtKB P00718
	Active site	105	1	By similarity UniProtKB P00718
Amino acid modifications
	Disulfide bond	23 ↔ 79		By similarity UniProtKB P00718
	Disulfide bond	37 ↔ 48		By similarity UniProtKB P00718

Sequences

	Sequence		Length	Mass (Da)
	G3XDD8 [UniParc]. Last modified December 14, 2011. Version 1. Checksum: 4061327BB92C820C	FASTA	204	22,493
	10 20 30 40 50 60 MHLMLVLLGL AALLGTSQSQ TGCYGVVNRI DTTGASCETA KPEKLNYCGV AASRMIAERD 70 80 90 100 110 120 LRSMDRYKTL IKKVGQKLCV DPAVIAGIIS RESHAGKALK NGWGDNGNGF GLMQVDKRSH 130 140 150 160 170 180 TPVGEWNGER HLTQGTEILI SMIKKIQKKF PRWTKEQQLK GGISAYNAGS GNVRSYERMD 190 200 IGTTHNDYAN DVVARAQYYK QHGY

References

[1]

"Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white." Maehashi K., Matano M., Irisawa T., Uchino M., Kashiwagi Y., Watanabe T. Gene 492:244-249(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Ovary and Oviduct.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB451700 mRNA. Translation: BAL03618.1. AB462632 Genomic DNA. Translation: BAL03619.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002152. Glyco_hydro_23. IPR023346. Lysozyme-like_dom. IPR008258. Lytic_TGlycosylase-like_cat. [Graphical view]
Pfam	PF01464. SLT. 1 hit. [Graphical view]
PIRSF	PIRSF001065. Lysozyme_g. 1 hit.
PRINTS	PR00749. LYSOZYMEG.
SUPFAM	SSF53955. SSF53955. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LYG_DRONO

Accession

Primary (citable) accession number: G3XDD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2012
Last sequence update:	December 14, 2011
Last modified:	October 3, 2012
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program