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Protein
Submitted name:

Complement factor I

Gene

CFI

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Complement factor IImported
Submitted name:
Complement factor I, isoform CRA_bImported
Gene namesi
Name:CFIImported
ORF Names:hCG_21044Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000205403.12.
HGNCiHGNC:5394. CFI.

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000205403.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_501109115719 – 576Sequence analysisAdd BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi186 ↔ 196PROSITE-ProRule annotation
Disulfide bondi229 ↔ 247PROSITE-ProRule annotation
Disulfide bondi241 ↔ 256PROSITE-ProRule annotation
Disulfide bondi259 ↔ 271PROSITE-ProRule annotation
Disulfide bondi266 ↔ 284PROSITE-ProRule annotation
Disulfide bondi278 ↔ 293PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Proteomic databases

MaxQBiG3XAM2.

Expressioni

Gene expression databases

BgeeiENSG00000205403.
ExpressionAtlasiG3XAM2. baseline and differential.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 108Kazal-likeInterPro annotationAdd BLAST49
Domaini114 – 215SRCRInterPro annotationAdd BLAST102
Domaini333 – 567Peptidase S1InterPro annotationAdd BLAST235

Sequence similaritiesi

Belongs to the peptidase S1 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00900000141113.

Family and domain databases

CDDicd00112. LDLa. 2 hits.
cd00190. Tryp_SPc. 1 hit.
Gene3Di3.10.250.10. 1 hit.
InterProiView protein in InterPro
IPR003884. FacI_MAC.
IPR002350. Kazal_dom.
IPR036058. Kazal_dom_sf.
IPR036055. LDL_receptor-like_sf.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR036772. SRCR-like_dom_sf.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
PfamiView protein in Pfam
PF00057. Ldl_recept_a. 2 hits.
PF00530. SRCR. 1 hit.
PF00089. Trypsin. 1 hit.
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiView protein in SMART
SM00057. FIMAC. 1 hit.
SM00192. LDLa. 2 hits.
SM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
SUPFAMiSSF100895. SSF100895. 1 hit.
SSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 2 hits.
PROSITEiView protein in PROSITE
PS51465. KAZAL_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 2 hits.
PS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

G3XAM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLHVFLLF LCFHLRFCKV TYTSQEDLVE KKCLAKKYTH LSCDKVFCQP
60 70 80 90 100
WQRCIEGTCV CKLPYQCPKN GTAVCATNRR SFPTYCQQKS LECLHPGTKF
110 120 130 140 150
LNNGTCTAEG KFSVSLKHGN TDSEGIVEVK LVDQDKTMFI CKSSWSMREA
160 170 180 190 200
NVACLDLGFQ QGADTQRRFK LSDLSINSTE CLHVHCRGLE TSLAECTFTK
210 220 230 240 250
RRTMGYQDFA DVVCYTQKAD SPMDDFFQCV NGKYISQMKA CDGINDCGDQ
260 270 280 290 300
SDELCCKACQ GKGFHCKSGV CIPSQYQCNG EVDCITGEDE VGCAEETEIL
310 320 330 340 350
TADMDAERRR IKSLLPKLSC GVKNRMHIRR KRIVGGKRAQ LGDLPWQVAI
360 370 380 390 400
KDASGITCGG IYIGGCWILT AAHCLRASKT HRYQIWTTVV DWIHPDLKRI
410 420 430 440 450
VIEYVDRIIF HENYNAGTYQ NDIALIEMKK DGNKKDCELP RSIPACVPWS
460 470 480 490 500
PYLFQPNDTC IVSGWGREKD NERVFSLQWG EVKLISNCSK FYGNRFYEKE
510 520 530 540 550
MECAGTYDGS IDACKGDSGG PLVCMDANNV TYVWGVVSWG ENCGKPEFPG
560 570
VYTKVANYFD WISYHVGRPF ISQYNV
Length:576
Mass (Da):65,060
Last modified:November 16, 2011 - v1
Checksum:iAB001AED6C1BF94A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126283 Genomic DNA. No translation available.
CH471057 Genomic DNA. Translation: EAX06251.1.
RefSeqiNP_001317964.1. NM_001331035.1.
UniGeneiHs.312485.

Genome annotation databases

EnsembliENST00000512148; ENSP00000427438; ENSG00000205403.
GeneIDi3426.
UCSCiuc062yzd.1. human.

Similar proteinsi

Entry informationi

Entry nameiG3XAM2_HUMAN
AccessioniPrimary (citable) accession number: G3XAM2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: December 20, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported