NOD1

Functionⁱ

GO - Biological processⁱ

regulation of apoptotic process Source: InterPro

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Caspase recruitment domain family, member 4, isoform CRA_cImported Submitted name: Nucleotide-binding oligomerization domain-containing protein 1Imported
Gene namesⁱ	Name:NOD1Imported Synonyms:CARD4Imported ORF Names:hCG_39138Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16390. NOD1.

HGNCⁱ

HGNC:16390. NOD1.

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000106100.

OpenTargetsⁱ

ENSG00000106100.

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	G3XAL1.

MaxQBⁱ

G3XAL1.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000106100.
ExpressionAtlasⁱ	G3XAL1. baseline and differential.

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	15 – 92	CARDInterPro annotationAdd BLAST		78
Domainⁱ	196 – 531	NACHTInterPro annotationAdd BLAST		336

Phylogenomic databases

eggNOGⁱ	KOG4308. Eukaryota. ENOG410ZBX3. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133673.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001315. CARD. IPR011029. DEATH-like_dom. IPR007111. NACHT_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00619. CARD. 1 hit.
SUPFAMⁱ	SSF47986. SSF47986. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50209. CARD. 1 hit. PS50837. NACHT. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

G3XAL1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEEQGHSEME IIPSESHPHI QLLKSNRELL VTHIRNTQCL VDNLLKNDYF 
        60         70         80         90        100
SAEDAEIVCA CPTQPDKVRK ILDLVQSKGE EVSEFFLYLL QQLADAYVDL 
       110        120        130        140        150
RPWLLEIGFS PSLLTQSKVV VNTDPVSRYT QQLRHHLGRD SKFVLCYAQK 
       160        170        180        190        200
EELLLEEIYM DTIMELVGFS NESLGSLNSL ACLLDHTTGI LNEQGETIFI 
       210        220        230        240        250
LGDAGVGKSM LLQRLQSLWA TGRLDAGVKF FFHFRCRMFS CFKESDRLCL 
       260        270        280        290        300
QDLLFKHYCY PERDPEEVFA FLLRFPHVAL FTFDGLDELH SDLDLSRVPD 
       310        320        330        340        350
SSCPWEPAHP LVLLANLLSG KLLKGASKLL TARTGIEVPR QFLRKKVLLR 
       360        370        380        390        400
GFSPSHLRAY ARRMFPERAL QDRLLSQLEA NPNLCSLCSV PLFCWIIFRC 
       410        420        430        440        450
FQHFRAAFEG SPQLPDCTMT LTDVFLLVTE VHLNRMQPSS LVQRNTRSPV 
       460        470        480        490        500
ETLHAGRDTL CSLGQVAHRG MEKSLFVFTQ EEVQASGLQE RDMQLGFLRA 
       510        520        530        540        550
LPELGPGGDQ QSYEFFHLTL QAFFTAFFLV LDDRVGTQEL LRFFQEWMPP 
       560        570        580        590        600
AGAATTSCYP PFLPFQCLQG SGPAREDLFK NKDHFQFTNL FLCGLLSKAK 
       610        620        630        640        650
QKLLRHLVPA AALRRKRKAL WAHLFSSLRG YLKSLPRVQV ESFNQVQAMP 
       660        670        680        690        700
TFIWMLRCIY ETQSQKVGQL AARGICANYL KLTYCNACSA DCSALSFVLH 
       710        720        730        740        750
HFPKRLALDL DNNNLNDYGV RELQPCFSRL TVLRLSVNQI TDGGVKVLSE 
       760        770 
ELTKYKIVTY LGLWKSVDTI CFKKQGLLK

Length:779

Mass (Da):88,842

Last modified:November 16, 2011 - v1

Checksum:ⁱ06801B8E4730A1D6

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC005154 Genomic DNA. No translation available. AC006027 Genomic DNA. No translation available. CH471073 Genomic DNA. Translation: EAW93948.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_011513390.1. XM_011515088.2.
UniGeneⁱ	Hs.405153. Hs.738731.

Genome annotation databases

Ensemblⁱ	ENST00000434755; ENSP00000416946; ENSG00000106100.
GeneIDⁱ	10392.
UCSC genome browser More...UCSCⁱ	uc064cml.1. human.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC005154 Genomic DNA. No translation available. AC006027 Genomic DNA. No translation available. CH471073 Genomic DNA. Translation: EAW93948.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_011513390.1. XM_011515088.2.
UniGeneⁱ	Hs.405153. Hs.738731.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	G3XAL1.

MaxQBⁱ

G3XAL1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000434755; ENSP00000416946; ENSG00000106100.
GeneIDⁱ	10392.
UCSC genome browser More...UCSCⁱ	uc064cml.1. human.

Organism-specific databases

CTDⁱ	10392.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16390. NOD1.
Open Targets More...OpenTargetsⁱ	ENSG00000106100.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4308. Eukaryota. ENOG410ZBX3. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00860000133673.

Miscellaneous databases

ChiTaRSⁱ	NOD1. human.
GenomeRNAiⁱ	10392.

Gene expression databases

Bgeeⁱ	ENSG00000106100.
ExpressionAtlasⁱ	G3XAL1. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001315. CARD. IPR011029. DEATH-like_dom. IPR007111. NACHT_NTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00619. CARD. 1 hit.
SUPFAMⁱ	SSF47986. SSF47986. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50209. CARD. 1 hit. PS50837. NACHT. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G3XAL1_HUMAN
Accessionⁱ	G3XAL1Primary (citable) accession number: G3XAL1
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 16, 2011
	Last sequence update:	November 16, 2011
	Last modified:	July 5, 2017
	This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB - G3XAL1 (G3XAL1_HUMAN)

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Caspase recruitment domain family, member 4, isoform CRA_c

Select a section on the left to see content.

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Organism-specific databases

Pathology & Biotechⁱ

Organism-specific databases

PTM / Processingⁱ

Proteomic databases

Expressionⁱ

Gene expression databases

Family & Domainsⁱ

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G3XAL1 (G3XAL1_HUMAN)

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Caspase recruitment domain family, member 4, isoform CRA_c

NOD1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ