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Protein

Malate dehydrogenase

Gene

MDH2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:MDH2Imported
ORF Names:hCG_1818102Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000146701.11
HGNCiHGNC:6971 MDH2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000146701

Expressioni

Gene expression databases

BgeeiENSG00000146701

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61Ldh_1_NInterPro annotationAdd BLAST61
Domaini63 – 227Ldh_1_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1494 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00390000016686

Family and domain databases

Gene3Di3.90.110.10, 1 hit
InterProiView protein in InterPro
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR001252 Malate_DH_AS
IPR010097 Malate_DH_type1
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01772 MDH_euk_gproteo, 1 hit
PROSITEiView protein in PROSITE
PS00068 MDH, 1 hit

Sequencei

Sequence statusi: Complete.

G3XAL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRDDLFNTN ATIVATLTAA CAQHCPEAMI CVIANPVNST IPITAEVFKK
60 70 80 90 100
HGVYNPNKIF GVTTLDIVRA NTFVAELKGL DPARVNVPVI GGHAGKTIIP
110 120 130 140 150
LISQCTPKVD FPQDQLTALT GRIQEAGTEV VKAKAGAGSA TLSMAYAGAR
160 170 180 190 200
FVFSLVDAMN GKEGVVECSF VKSQETECTY FSTPLLLGKK GIEKNLGIGK
210 220 230
VSSFEEKMIS DAIPELKASI KKGEDFVKTL K
Length:231
Mass (Da):24,595
Last modified:November 16, 2011 - v1
Checksum:iF90A418BCE2CFD3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005077 Genomic DNA No translation available.
AC006330 Genomic DNA No translation available.
CH471220 Genomic DNA Translation: EAW71797.1
RefSeqiNP_001269333.1, NM_001282404.1
UniGeneiHs.520967

Genome annotation databases

EnsembliENST00000443006; ENSP00000416929; ENSG00000146701
GeneIDi4191
UCSCiuc003uep.5 human

Similar proteinsi

Entry informationi

Entry nameiG3XAL0_HUMAN
AccessioniPrimary (citable) accession number: G3XAL0
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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