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Protein
Submitted name:

E3 ubiquitin-protein ligase Mdm2

Gene

MDM2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase Mdm2Imported
Submitted name:
Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (Mouse), isoform CRA_gImported
Gene namesi
Name:MDM2Imported
ORF Names:hCG_2014981Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6973. MDM2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135679.

Expressioni

Gene expression databases

BgeeiENSG00000135679.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 279RanBP2-typeInterPro annotationAdd BLAST30
Domaini389 – 430RING-typeInterPro annotationAdd BLAST42

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063539.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR028340. Mdm2.
IPR015459. MDM2_E3_ligase.
IPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
IPR001876. Znf_RanBP2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR13844:SF15. PTHR13844:SF15. 1 hit.
PfamiPF02201. SWIB. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
PIRSFiPIRSF500700. MDM2. 1 hit.
PIRSF006748. p53_MDM_2/4. 1 hit.
SUPFAMiSSF47592. SSF47592. 2 hits.
SSF90209. SSF90209. 1 hit.
PROSITEiPS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3XA89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRSRQMCNT NMSVPTDGAV TTSQIPASEQ ETLVRPKPLL LKLLKSVGAQ
60 70 80 90 100
KDTYTMKEVL FYLGQYIMTK RLYDEKQQHI VYCSNDLLGD LFGVPSFSVK
110 120 130 140 150
EHRKIYTMIY RNLVVVNQQE ENSDELSGER QRKRHKSDSI SLSFDESLAL
160 170 180 190 200
CVIREICCER SSSSESTGTP SNPDLDAGVS EHSGDWLDQD SVSDQFSVEF
210 220 230 240 250
EVESLDSEDY SLSEEGQELS DEDDEVYQVT VYQAGESDTD SFEEDPEISL
260 270 280 290 300
ADYWKCTSCN EMNPPLPSHC NRCWALRENW LPEDKGKDKG EISEKAKLEN
310 320 330 340 350
STQAEEGFDV PDCKKTIVND SRESCVEEND DKITQASQSQ ESEDYSQPST
360 370 380 390 400
SSSIIYSSQE DVKEFEREET QDKEESVESS LPLNAIEPCV ICQGRPKNGC
410 420 430 440
IVHGKTGHLM ACFTCAKKLK KRNKPCPVCR QPIQMIVLTY FP
Length:442
Mass (Da):50,006
Last modified:November 16, 2011 - v1
Checksum:i3A785D132314D9BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025423 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97207.1.
RefSeqiNP_001138811.1. NM_001145339.2.
UniGeneiHs.484551.
Hs.733536.

Genome annotation databases

EnsembliENST00000258148; ENSP00000258148; ENSG00000135679.
GeneIDi4193.
UCSCiuc009zqx.6. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC025423 Genomic DNA. No translation available.
CH471054 Genomic DNA. Translation: EAW97207.1.
RefSeqiNP_001138811.1. NM_001145339.2.
UniGeneiHs.484551.
Hs.733536.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258148; ENSP00000258148; ENSG00000135679.
GeneIDi4193.
UCSCiuc009zqx.6. human.

Organism-specific databases

CTDi4193.
HGNCiHGNC:6973. MDM2.
OpenTargetsiENSG00000135679.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063539.

Miscellaneous databases

ChiTaRSiMDM2. human.
GenomeRNAii4193.

Gene expression databases

BgeeiENSG00000135679.

Family and domain databases

Gene3Di1.10.245.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR028340. Mdm2.
IPR015459. MDM2_E3_ligase.
IPR016495. p53_neg-reg_MDM_2/4.
IPR003121. SWIB_MDM2_domain.
IPR001876. Znf_RanBP2.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR13844:SF15. PTHR13844:SF15. 1 hit.
PfamiPF02201. SWIB. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
PIRSFiPIRSF500700. MDM2. 1 hit.
PIRSF006748. p53_MDM_2/4. 1 hit.
SUPFAMiSSF47592. SSF47592. 2 hits.
SSF90209. SSF90209. 1 hit.
PROSITEiPS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3XA89_HUMAN
AccessioniPrimary (citable) accession number: G3XA89
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 30, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.