Brefeldin A-inhibited guanine nucleotide-exchange protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ARF guanyl-nucleotide exchange factor activity Source: GO_Central
• guanyl-nucleotide exchange factor activity Source: MGI
• myosin binding Source: MGI
• protein kinase A regulatory subunit binding Source: UniProtKB

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• endomembrane system organization Source: UniProtKB
• Golgi organization Source: UniProtKB
• negative regulation of actin filament polymerization Source: UniProtKB
• negative regulation of GTPase activity Source: UniProtKB
• neuron projection development Source: Ensembl
• positive regulation of protein glycosylation in Golgi Source: UniProtKB
• positive regulation of protein kinase B signaling Source: Ensembl
• positive regulation of wound healing Source: UniProtKB
• protein transport Source: UniProtKB-KW
• regulation of ARF protein signal transduction Source: InterPro
• regulation of establishment of cell polarity Source: UniProtKB
• vesicle-mediated transport Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section"><span class="caps">PTM</span>/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ARF guanyl-nucleotide exchange factor activity Source: GO_Central
• guanyl-nucleotide exchange factor activity Source: MGI
• myosin binding Source: MGI
• protein kinase A regulatory subunit binding Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MYEGKKTKNM FLTRALEKIL ADKEVKKAHH SQLRKACEVA LEEIKVETEK 
        60         70         80         90        100
QSPPHGEAKA GSGTLPPVKS KTNFIEADKY FLPFELACQS KCPRIVSTSL 
       110        120        130        140        150
DCLQKLIAYG HLTGRAPDST TPGKKLIDRI IETICGCFQG PQTDEGVQLQ 
       160        170        180        190        200
IIKALLTAVT SQHIEIHEGT VLQAVRTCYN IYLASKNLIN QTTAKATLTQ 
       210        220        230        240        250
MLNVIFARME NQALQEAKQM ERERHRQQQH LLQSPVSHHE PESPHLRYLP 
       260        270        280        290        300
PQTVDHINQE HEGDLEPQTH DVDKSLQDDT EPENGSDISS AENEQTEADQ 
       310        320        330        340        350
ATAAETLSKN DILYDGDYEE KPLDIVQSIV EEMVNIIVGD MGEGMAISAS 
       360        370        380        390        400
TEGNTGTVED GSDSENIQAN GIPGTPISVA YTPSLPDDRL SVSSNDTQES 
       410        420        430        440        450
GNSSGPSPGA KFSHILQKDA FLVFRSLCKL SMKPLSDGPP DPKSHELRSK 
       460        470        480        490        500
ILSLQLLLSI LQNAGPVFRT NEMFINAIKQ YLCVALSKNG VSSVPEVFEL 
       510        520        530        540        550
SLSIFLTLLS NFKTHLKMQI EVFFKEIFLY ILETSTSSFD HKWMVIQTLT 
       560        570        580        590        600
RICADAQSVV DIYVNYDCDL NAANIFERLV NDLSKIAQGR GSQELGMSNV 
       610        620        630        640        650
QELSLRKKGL ECLVSILKCM VEWSKDQYVN PNSQTTLGQE KPSEQEISEV 
       660        670        680        690        700
KHPETINRYG SLNSLESTSS SGIGSYSTQM SGTDNPEQFE VLKQQKEIIE 
       710        720        730        740        750
QGIDLFNKKP KRGIQYLQEQ GMLGTTPEDI AQFLHQEERL DSTQVGEFLG 
       760        770        780        790        800
DNDKFNKEVM YAYVDQHDFS GKDFVSALRL FLEGFRLPGE AQKIDRLMEK 
       810        820        830        840        850
FAARYLECNQ GQTLFASADT AYVLAYSIIM LTTDLHSPQV KNKMTKEQYI 
       860        870        880        890        900
KMNRGINDSK DLPEEYLSAI YNEIAGKKIS MKETKELTIP TKSTKQNVAS 
       910        920        930        940        950
EKQRRLLYNL EMEQMAKTAK ALMEAVSHVQ APFTSATHLE HVRPMFKLAW 
       960        970        980        990       1000
TPFLAAFSVG LQDCDDTEVA SLCLEGIRCA IRIACIFSIQ LERDAYVQAL 
      1010       1020       1030       1040       1050
ARFTLLTVSS GITEMKQKNI DTIKTLITVA HTDGNYLGNS WHEILKCISQ 
      1060       1070       1080       1090       1100
LELAQLIGTG VKPRYISGTV RGREGSLTGT KDQAPDEFVG LGLVGGNVDW 
      1110       1120       1130       1140       1150
KQIASIQESI GETSSQSVVV AVDRIFTGST RLDGNAIVDF VRWLCAVSMD 
      1160       1170       1180       1190       1200
ELLSTTHPRM FSLQKIVEIS YYNMGRIRLQ WSRIWEVIGD HFNKVGCNPN 
      1210       1220       1230       1240       1250
EDVAIFAVDS LRQLSMKFLE KGELANFRFQ KDFLRPFEHI MKRNRSPTIR 
      1260       1270       1280       1290       1300
DMVVRCIAQM VNSQAANIRS GWKNIFSVFH LAASDQDESI VELAFQTTGH 
      1310       1320       1330       1340       1350
IVTLVFEKHF PATIDSFQDA VKCLSEFACN AAFPDTSMEA IRLIRHCAKY 
      1360       1370       1380       1390       1400
VSDRPQAFKE YTSDDMSVAP EDRVWVRGWF PILFELSCII NRCKLDVRTR 
      1410       1420       1430       1440       1450
GLTVMFEIMK TYGHTYEKHW WQDLFRIVFR IFDNMKLPEQ QTEKAEWMTT 
      1460       1470       1480       1490       1500
TCNHALYAIC DVFTQYLEVL SDVLLDDIFA QLYWCVQQDN EQLARSGTNC 
      1510       1520       1530       1540       1550
LENVVILNGE KFTLEIWDKT CNCTLDIFKT TIPHALLTWR PTSGEAEPPS 
      1560       1570       1580       1590       1600
PSAVSEKPLD AISQKSVDIH DSIQPRSSDN RQQAPLVSVS TVSEEVSKVK 
      1610       1620       1630       1640       1650
STAKFPEQKL FAALLIKCVV QLELIQTIDN IVFFPATSKK EDAENLAAAQ 
      1660       1670       1680       1690       1700
RDAVDFDVRV DTQDQGMYRF LTSQQLFKLL DCLLESHRFA KAFNSNNEQR 
      1710       1720       1730       1740       1750
TALWKAGFKG KSKPNLLKQE TSSLACGLRI LFRMYMDESR VSAWEEVQQR 
      1760       1770       1780       1790       1800
LLNVCREALS YFLTLTSESH REAWTNLLLL FLTKVLKISD SRFKAHASFY 
      1810       1820       1830       1840 
YPLLCEIMQF DLIPELRAVL RRFFLRIGIV FQISQPPEQE LGINRQ     

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ