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Protein
Submitted name:

E3 ubiquitin-protein ligase NEDD4-like

Gene

Nedd4l

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

LigaseSAAS annotation

Keywords - Biological processi

Ubl conjugation pathwaySAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-MMU-2672351. Stimuli-sensing channels.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
E3 ubiquitin-protein ligase NEDD4-likeImported
Submitted name:
Neural cell expressed, developmentally down-regulated gene 4-like, isoform CRA_aImported
Gene namesi
Name:Nedd4lImported
ORF Names:mCG_131856Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1933754. Nedd4l.

PTM / Processingi

Proteomic databases

PeptideAtlasiG3X9H8.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132838.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 10534WWInterPro annotationAdd
BLAST
Domaini265 – 29834WWInterPro annotationAdd
BLAST
Domaini377 – 41034WWInterPro annotationAdd
BLAST
Domaini428 – 46134WWInterPro annotationAdd
BLAST
Domaini520 – 854335HECT (E6AP-type E3 ubiquitin-protein ligase)InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains HECT (E6AP-type E3 ubiquitin-protein ligase) domain.SAAS annotation

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00760000118966.

Family and domain databases

InterProiIPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00397. WW. 4 hits.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00456. WW. 4 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 4 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 4 hits.
PS50020. WW_DOMAIN_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3X9H8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERPYTFKDF LLRPRSHKSR VKGFLRLKMA YMPKNGGQDE ENSEQRDDME
60 70 80 90 100
HGWEVVDSND SASQHQEELP PPPLPPGWEE KVDNLGRTYY VNHNNRSTQW
110 120 130 140 150
HRPSLMDVSS ESDNNIRQIN QEAAHRRFRS RRHISEDLEP EASEGGGEGP
160 170 180 190 200
EPWETISEEM NMAGDSLSLA LPPPPASPVS RTSPQELSEE VSRRLQITPD
210 220 230 240 250
SNGEQFSSLI QREPSSRLRS CSVTDTVAEQ AHLPPPSTPT RRARSSTVTG
260 270 280 290 300
GEESTPSVAY VHTTPGLPSG WEERKDAKGR TYYVNHNNRT TTWTRPIMQL
310 320 330 340 350
AEDGASGSAT NSNNHLVEPQ IRRPRSLSSP TVTLSAPLEG AKDSPIRRAV
360 370 380 390 400
KDTLSNPQSP QPSPYNSPKP QHKVTQSFLP PGWEMRIAPN GRPFFIDHNT
410 420 430 440 450
KTTTWEDPRL KFPVHMRSKA SLNPNDLGPL PPGWEERIHL DGRTFYIDHN
460 470 480 490 500
SKITQWEDPR LQNPAITGPA VPYSREFKQK YDYFRKKLKK PADIPNRFEM
510 520 530 540 550
KLHRNNIFEE SYRRIMSVKR PDVLKARLWI EFESEKGLDY GGVAREWFFL
560 570 580 590 600
LSKEMFNPYY GLFEYSATDN YTLQINPNSG LCNEDHLSYF TFIGRVAGLA
610 620 630 640 650
VFHGKLLDGF FIRPFYKMML GKQITLNDME SVDSEYYNSL KWILENDPTE
660 670 680 690 700
LDLMFCIDEE NFGQTYQVDL KPNGSEIMVT NENKREYIDL VIQWRFVNRV
710 720 730 740 750
QKQMNAFLEG FTELLPIDLI KIFDENELEL LMCGLGDVDV NDWRQHSIYK
760 770 780 790 800
NGYCPNHPVI QWFWKAVLLM DAEKRIRLLQ FVTGTSRVPM NGFAELYGSN
810 820 830 840 850
GPQLFTIEQW GSPEKLPRAH TCFNRLDLPP YETFEDLREK LLMAVENAQG

FEGVD
Length:855
Mass (Da):98,456
Last modified:November 16, 2011 - v1
Checksum:i09C5074054F43F83
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102288 Genomic DNA. No translation available.
AC102333 Genomic DNA. No translation available.
AC131709 Genomic DNA. No translation available.
AC161175 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL09694.1.
RefSeqiNP_114087.2. NM_031881.2.
XP_006526439.1. XM_006526376.2.
XP_006526440.1. XM_006526377.2.
XP_006526441.1. XM_006526378.2.
XP_006526442.1. XM_006526379.2.
XP_006526443.1. XM_006526380.1.
XP_006526445.1. XM_006526382.2.
XP_011245346.1. XM_011247044.1.
XP_011245347.1. XM_011247045.1.
XP_011245348.1. XM_011247046.1.
UniGeneiMm.98668.

Genome annotation databases

EnsembliENSMUST00000080418; ENSMUSP00000079280; ENSMUSG00000024589.
GeneIDi83814.
UCSCiuc008fer.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102288 Genomic DNA. No translation available.
AC102333 Genomic DNA. No translation available.
AC131709 Genomic DNA. No translation available.
AC161175 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL09694.1.
RefSeqiNP_114087.2. NM_031881.2.
XP_006526439.1. XM_006526376.2.
XP_006526440.1. XM_006526377.2.
XP_006526441.1. XM_006526378.2.
XP_006526442.1. XM_006526379.2.
XP_006526443.1. XM_006526380.1.
XP_006526445.1. XM_006526382.2.
XP_011245346.1. XM_011247044.1.
XP_011245347.1. XM_011247045.1.
XP_011245348.1. XM_011247046.1.
UniGeneiMm.98668.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000132838.

Proteomic databases

PeptideAtlasiG3X9H8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080418; ENSMUSP00000079280; ENSMUSG00000024589.
GeneIDi83814.
UCSCiuc008fer.2. mouse.

Organism-specific databases

CTDi23327.
MGIiMGI:1933754. Nedd4l.

Phylogenomic databases

eggNOGiKOG0940. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00760000118966.

Enzyme and pathway databases

ReactomeiR-MMU-2173795. Downregulation of SMAD2/3:SMAD4 transcriptional activity.
R-MMU-2672351. Stimuli-sensing channels.
R-MMU-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiNedd4l. mouse.
SOURCEiSearch...

Family and domain databases

InterProiIPR000569. HECT_dom.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00397. WW. 4 hits.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
SM00456. WW. 4 hits.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 4 hits.
SSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS01159. WW_DOMAIN_1. 4 hits.
PS50020. WW_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG3X9H8_MOUSE
AccessioniPrimary (citable) accession number: G3X9H8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 6, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.