G3X9H5 (G3X9H5_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Huntingtin Ensembl ENSMUSP00000078945

Submitted name:
Huntington disease gene homolog, isoform CRA_a EMBL EDL37467.1

Gene names

Name:	Htt MGI 96067 Ensembl ENSMUSP00000078945
Synonyms:	Hdh EMBL EDL37467.1
ORF Names:	mCG_2547 EMBL EDL37467.1

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000078945

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	3120 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ER to Golgi vesicle-mediated transport Inferred from mutant phenotype PubMed 11092755. Source: MGI Golgi organization Inferred from electronic annotation. Source: Compara L-glutamate import Inferred from mutant phenotype PubMed 10932179. Source: MGI anterior/posterior pattern specification Inferred from mutant phenotype PubMed 16109169. Source: MGI axon cargo transport Inferred from mutant phenotype PubMed 15340079. Source: MGI cell aging Inferred from mutant phenotype PubMed 16403806. Source: MGI citrulline metabolic process Inferred from mutant phenotype PubMed 17213233. Source: MGI determination of adult lifespan Inferred from mutant phenotype PubMed 11062468PubMed 11152661. Source: MGI dopamine receptor signaling pathway Inferred from mutant phenotype PubMed 17715336. Source: MGI endoplasmic reticulum organization Inferred from mutant phenotype PubMed 16256944. Source: MGI endosomal transport Inferred from mutant phenotype PubMed 11092755. Source: MGI establishment of mitotic spindle orientation Inferred from electronic annotation. Source: Compara hormone metabolic process Inferred from mutant phenotype PubMed 10078572PubMed 10739639. Source: MGI insulin secretion Inferred from mutant phenotype PubMed 10078572. Source: MGI iron ion homeostasis Inferred from mutant phenotype PubMed 11092755. Source: MGI lactate biosynthetic process from pyruvate Inferred from mutant phenotype PubMed 17708681. Source: MGI locomotory behavior Inferred from mutant phenotype PubMed 11062468PubMed 11152661PubMed 11567051PubMed 12223581PubMed 12926013PubMed 16403806PubMed 17715336PubMed 7774020. Source: MGI negative regulation of extrinsic apoptotic signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of neuron apoptotic process Inferred from mutant phenotype PubMed 11152661. Source: MGI neural plate formation Inferred from mutant phenotype PubMed 7774020. Source: MGI neuron apoptotic process Inferred from mutant phenotype PubMed 10082833PubMed 10932179. Source: MGI neuron development Inferred from mutant phenotype PubMed 10082833PubMed 16978870PubMed 7774020. Source: MGI olfactory lobe development Inferred from mutant phenotype PubMed 12926013. Source: MGI paraxial mesoderm formation Inferred from mutant phenotype PubMed 16109169. Source: MGI protein import into nucleus Inferred from mutant phenotype PubMed 11092755. Source: MGI quinolinate biosynthetic process Inferred from mutant phenotype PubMed 16697652. Source: MGI regulation of mitochondrial membrane permeability Inferred from mutant phenotype PubMed 15935052. Source: MGI regulation of mitochondrial membrane potential Inferred from mutant phenotype PubMed 17708681. Source: MGI regulation of protein phosphatase type 2A activity Inferred from electronic annotation. Source: Compara regulation of synaptic plasticity Inferred from mutant phenotype PubMed 10196373PubMed 17442827. Source: MGI response to calcium ion Inferred from mutant phenotype PubMed 15935052. Source: MGI retrograde vesicle-mediated transport, Golgi to ER Inferred from electronic annotation. Source: Compara social behavior Inferred from mutant phenotype PubMed 10196365. Source: MGI spermatogenesis Inferred from mutant phenotype PubMed 11062468. Source: MGI striatum development Inferred from mutant phenotype PubMed 11030759PubMed 17715336. Source: MGI urea cycle Inferred from mutant phenotype PubMed 17213233. Source: MGI vesicle transport along microtubule Inferred from direct assay PubMed 15242649. Source: MGI visual learning Inferred from mutant phenotype PubMed 7774020. Source: MGI
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: Compara autophagic vacuole Inferred from electronic annotation. Source: Compara axon Inferred from direct assay PubMed 12115678PubMed 8757264. Source: MGI cytoplasmic membrane-bounded vesicle Inferred from direct assay PubMed 15242649. Source: MGI cytoplasmic vesicle membrane Inferred from electronic annotation. Source: Compara cytosol Inferred from electronic annotation. Source: Compara dendrite Inferred from electronic annotation. Source: Compara endoplasmic reticulum Inferred from electronic annotation. Source: Compara inclusion body Inferred from direct assay PubMed 15615787. Source: MGI late endosome Inferred from electronic annotation. Source: Compara nucleus Inferred from Biological aspect of Ancestor. Source: RefGenome protein complex Inferred from electronic annotation. Source: Compara
Molecular_function	diazepam binding Inferred from mutant phenotype PubMed 10082833. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G3X9H5 [UniParc]. Last modified November 16, 2011. Version 1. Checksum: 53CCDC45D53B8BA3	FASTA	3,120	344,788
	10 20 30 40 50 60 MATLEKLMKA FESLKSFQQQ QQQQPPPQAP PPPPPPPPPQ PPQPPPQGQP PPPPPPLPGP 70 80 90 100 110 120 AEEPLHRPKK ELSATKKDRV NHCLTICENI VAQSLRNSPE FQKLLGIAME LFLLCSDDAE 130 140 150 160 170 180 SDVRMVADEC LNKVIKALMD SNLPRLQLEL YKEIKKNGAP RSLRAALWRF AELAHLVRPQ 190 200 210 220 230 240 KCRPYLVNLL PCLTRTSKRP EESVQETLAA AVPKIMASFG NFANDNEIKV LLKAFIANLK 250 260 270 280 290 300 SSSPTVRRTA AGSAVSICQH SRRTQYFYNW LLNVLLGLLV PMEEEHSTLL ILGVLLTLRC 310 320 330 340 350 360 LVPLLQQQVK DTSLKGSFGV TRKEMEVSPS TEQLVQVYEL TLHHTQHQDH NVVTGALELL 370 380 390 400 410 420 QQLFRTPPPE LLQALTTPGG LGQLTLVQEE ARGRGRSGSI VELLAGGGSS CSPVLSRKQK 430 440 450 460 470 480 GKVLLGEEEA LEDDSESRSD VSSSAFAASV KSEIGGELAA SSGVSTPGSV GHDIITEQPR 490 500 510 520 530 540 SQHTLQADSV DLSGCDLTSA ATDGDEEDIL SHSSSQFSAV PSDPAMDLND GTQASSPISD 550 560 570 580 590 600 SSQTTTEGPD SAVTPSDSSE IVLDGADSQY LGMQIGQPQE DDEEGAAGVL SGEVSDVFRN 610 620 630 640 650 660 SSLALQQAHL LERMGHSRQP SDSSIDKYVT RDEVAEASDP ESKPCRIKGD IGQPNDDDSA 670 680 690 700 710 720 PLVHCVRLLS ASFLLTGEKK ALVPDRDVRV SVKALALSCI GAAVALHPES FFSRLYKVPL 730 740 750 760 770 780 NTTESTEEQY VSDILNYIDH GDPQVRGATA ILCGTLVYSI LSRSRLRVGD WLGNIRTLTG 790 800 810 820 830 840 NTFSLVDCIP LLQKTLKDES SVTCKLACTA VRHCVLSLCS SSYSDLGLQL LIDMLPLKNS 850 860 870 880 890 900 SYWLVRTELL DTLAEIDFRL VSFLEAKAES LHRGAHHYTG FLKLQERVLN NVVIYLLGDE 910 920 930 940 950 960 DPRVRHVAAT SLTRLVPKLF YKCDQGQADP VVAVARDQSS VYLKLLMHET QPPSHFSVST 970 980 990 1000 1010 1020 ITRIYRGYSL LPSITDVTME NNLSRVVAAV SHELITSTTR ALTFGCCEAL CLLSAAFPVC 1030 1040 1050 1060 1070 1080 TWSLGWHCGV PPLSASDESR KSCTVGMASM ILTLLSSAWF PLDLSAHQDA LILAGNLLAA 1090 1100 1110 1120 1130 1140 SAPKSLRSSW TSEEEANSAA TRQEEIWPAL GDRTLVPLVE QLFSHLLKVI NICAHVLDDV 1150 1160 1170 1180 1190 1200 TPGPAIKAAL PSLTNPPSLS PIRRKGKEKE PGEQASTPMS PKKVGEASAA SRQSDTSGPV 1210 1220 1230 1240 1250 1260 TASKSSSLGS FYHLPSYLKL HDVLKATHAN YKVTLDLQNS TEKFGGFLRS ALDVLSQILE 1270 1280 1290 1300 1310 1320 LATLQDIGKC VEEVLGYLKS CFSREPMMAT VCVQQLLKTL FGTNLASQFD GLSSNPSKSQ 1330 1340 1350 1360 1370 1380 CRAQRLGSSS VRPGLYHYCF MAPYTHFTQA LADASLRNMV QAEQERDASG WFDVLQKVSA 1390 1400 1410 1420 1430 1440 QLKTNLTSVT KNRADKNAIH NHIRLFEPLV IKALKQYTTT TSVQLQKQVL DLLAQLVQLR 1450 1460 1470 1480 1490 1500 VNYCLLDSDQ VFIGFVLKQF EYIEVGQFRE SEAIIPNIFF FLVLLSYERY HSKQIIGIPK 1510 1520 1530 1540 1550 1560 IIQLCDGIMA SGRKAVTHAI PALQPIVHDL FVLRGTNKAD AGKELETQKE VVVSMLLRLI 1570 1580 1590 1600 1610 1620 QYHQVLEMFI LVLQQCHKEN EDKWKRLSRQ VADIILPMLA KQQMHIDSHE ALGVLNTLFE 1630 1640 1650 1660 1670 1680 ILAPSSLRPV DMLLRSMFIT PSTMASVSTV QLWISGILAI LRVLISQSTE DIVLCRIQEL 1690 1700 1710 1720 1730 1740 SFSPHLLSCP VINRLRGGGG NVTLGECSEG KQKSLPEDTF SRFLLQLVGI LLEDIVTKQL 1750 1760 1770 1780 1790 1800 KVDMSEQQHT FYCQELGTLL MCLIHIFKSG MFRRITAAAT RLFTSDGCEG SFYTLESLNA 1810 1820 1830 1840 1850 1860 RVRSMVPTHP ALVLLWCQIL LLINHTDHRW WAEVQQTPKR HSLSCTKSLN PQKSGEEEDS 1870 1880 1890 1900 1910 1920 GSAAQLGMCN REIVRRGALI LFCDYVCQNL HDSEHLTWLI VNHIQDLISL SHEPPVQDFI 1930 1940 1950 1960 1970 1980 SAIHRNSAAS GLFIQAIQSR CENLSTPTTL KKTLQCLEGI HLSQSGAVLT LYVDRLLGTP 1990 2000 2010 2020 2030 2040 FRALARMVDT LACRRVEMLL AANLQSSMAQ LPEEELNRIQ EHLQNSGLAQ RHQRLYSLLD 2050 2060 2070 2080 2090 2100 RFRLSTVQDS LSPLPPVTSH PLDGDGHTSL ETVSPDKDWY LQLVRSQCWT RSDSALLEGA 2110 2120 2130 2140 2150 2160 ELVNRIPAED MNDFMMSSEF NLSLLAPCLS LGMSEIANGQ KSPLFEAARG VILNRVTSVV 2170 2180 2190 2200 2210 2220 QQLPAVHQVF QPFLPIEPTA YWNKLNDLLG DTTSYQSLTI LARALAQYLV VLSKVPAHLH 2230 2240 2250 2260 2270 2280 LPPEKEGDTV KFVVMTVEAL SWHLIHEQIP LSLDLQAGLD CCCLALQVPG LWGVLSSPEY 2290 2300 2310 2320 2330 2340 VTHACSLIHC VRFILEAIAV QPGDQLLGPE SRSHTPRAVR KEEVDSDIQN LSHVTSACEM 2350 2360 2370 2380 2390 2400 VADMVESLQS VLALGHKRNS TLPSFLTAVL KNIVISLARL PLVNSYTRVP PLVWKLGWSP 2410 2420 2430 2440 2450 2460 KPGGDFGTVF PEIPVEFLQE KEILKEFIYR INTLGWTNRT QFEETWATLL GVLVTQPLVM 2470 2480 2490 2500 2510 2520 EQEESPPEED TERTQIHVLA VQAITSLVLS AMTVPVAGNP AVSCLEQQPR NKPLKALDTR 2530 2540 2550 2560 2570 2580 FGRKLSMIRG IVEQEIQEMV SQRENTATHH SHQAWDPVPS LLPATTGALI SHDKLLLQIN 2590 2600 2610 2620 2630 2640 PEREPGNMSY KLGQVSIHSV WLGNNITPLR EEEWDEEEEE ESDVPAPTSP PVSPVNSRKH 2650 2660 2670 2680 2690 2700 RAGVDIHSCS QFLLELYSRW ILPSSAARRT PVILISEVVR SLLVVSDLFT ERTQFEMMYL 2710 2720 2730 2740 2750 2760 TLTELRRVHP SEDEILIQYL VPATCKAAAV LGMDKTVAEP VSRLLESTLR SSHLPSQIGA 2770 2780 2790 2800 2810 2820 LHGILYVLEC DLLDDTAKQL IPVVSDYLLS NLKGIAHCVN IHSQQHVLVM CATAFYLMEN 2830 2840 2850 2860 2870 2880 YPLDVGPEFS ASVIQMCGVM LSGSEESTPS IIYHCALRGL ERLLLSEQLS RLDTESLVKL 2890 2900 2910 2920 2930 2940 SVDRVNVQSP HRAMAALGLM LTCMYTGKEK ASPGRASDPS PATPDSESVI VAMERVSVLF 2950 2960 2970 2980 2990 3000 DRIRKGFPCE ARVVARILPQ FLDDFFPPQD VMNKVIGEFL SNQQPYPQFM ATVVYKVFQT 3010 3020 3030 3040 3050 3060 LHSAGQSSMV RDWVMLSLSN FTQRTPVAMA MWSLSCFLVS ASTSPWVSAI LPHVISRMGK 3070 3080 3090 3100 3110 3120 LEQVDVNLFC LVATDFYRHQ IEEEFDRRAF QSVFEVVAAP GSPYHRLLAC LQNVHKVTTC

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL37467.1.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL37467.1.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000078945.
[4]	Ensembl Submitted (SEP-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000078945.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC133204 Genomic DNA. No translation available. AC151669 Genomic DNA. No translation available. CH466524 Genomic DNA. Translation: EDL37467.1.
RefSeq	NP_034544.1. NM_010414.2.
UniGene	Mm.209071.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000080036; ENSMUSP00000078945; ENSMUSG00000029104.
GeneID	15194.
KEGG	mmu:15194.
Organism-specific databases
CTD	3064.
MGI	MGI:96067. Htt.
Phylogenomic databases
GeneTree	ENSGT00390000015863.
KO	K04533.
OMA	DSEHLTW.
Family and domain databases
Gene3D	1.25.10.10. 4 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000091. Huntingtin. IPR024613. Huntingtin_middle-repeat. [Graphical view]
PANTHER	PTHR10170. PTHR10170. 1 hit.
Pfam	PF12372. DUF3652. 2 hits. [Graphical view]
PRINTS	PR00375. HUNTINGTIN.
SUPFAM	SSF48371. ARM-type_fold. 1 hit.
ProtoNet	Search...
Other
ChiTaRS	HTT. mouse.
NextBio	287727.
SOURCE	Search...

Entry information

Entry name

G3X9H5_MOUSE

Accession

Primary (citable) accession number: G3X9H5

Entry history

Integrated into UniProtKB/TrEMBL:	November 16, 2011
Last sequence update:	November 16, 2011
Last modified:	April 3, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)