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G3X9H5

- G3X9H5_MOUSE

UniProt

G3X9H5 - G3X9H5_MOUSE

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Protein
Submitted name:

Huntingtin

Gene

Htt

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. diazepam binding Source: MGI
  2. transcription factor binding Source: MGI

GO - Biological processi

  1. anatomical structure morphogenesis Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. apoptotic process Source: MGI
  4. associative learning Source: MGI
  5. axon cargo transport Source: MGI
  6. brain development Source: MGI
  7. cell aging Source: MGI
  8. central nervous system development Source: MGI
  9. citrulline metabolic process Source: MGI
  10. determination of adult lifespan Source: MGI
  11. dopamine receptor signaling pathway Source: MGI
  12. endoplasmic reticulum organization Source: MGI
  13. endosomal transport Source: MGI
  14. ER to Golgi vesicle-mediated transport Source: MGI
  15. establishment of mitotic spindle orientation Source: Ensembl
  16. gastrulation Source: MGI
  17. Golgi organization Source: Ensembl
  18. grooming behavior Source: MGI
  19. hormone metabolic process Source: MGI
  20. insulin secretion Source: MGI
  21. iron ion homeostasis Source: MGI
  22. lactate biosynthetic process from pyruvate Source: MGI
  23. learning Source: MGI
  24. learning or memory Source: MGI
  25. L-glutamate import Source: MGI
  26. locomotory behavior Source: MGI
  27. mitochondrial transport Source: MGI
  28. mitochondrion organization Source: MGI
  29. negative regulation of apoptotic process Source: MGI
  30. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  31. negative regulation of neuron apoptotic process Source: MGI
  32. negative regulation of neuron death Source: MGI
  33. neural plate formation Source: MGI
  34. neurogenesis Source: MGI
  35. neuron apoptotic process Source: MGI
  36. neuron development Source: MGI
  37. olfactory lobe development Source: MGI
  38. paraxial mesoderm formation Source: MGI
  39. peptide hormone secretion Source: MGI
  40. protein import into nucleus Source: MGI
  41. quinolinate biosynthetic process Source: MGI
  42. regulation of mitochondrial membrane permeability Source: MGI
  43. regulation of mitochondrial membrane potential Source: MGI
  44. regulation of protein phosphatase type 2A activity Source: Ensembl
  45. regulation of synaptic plasticity Source: MGI
  46. response to calcium ion Source: MGI
  47. retrograde vesicle-mediated transport, Golgi to ER Source: Ensembl
  48. social behavior Source: MGI
  49. spermatogenesis Source: MGI
  50. striatum development Source: MGI
  51. urea cycle Source: MGI
  52. vesicle transport along microtubule Source: MGI
  53. visual learning Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HuntingtinImported
Submitted name:
Huntington disease gene homolog, isoform CRA_aImported
Gene namesi
Name:HttImported
Synonyms:HdhImported
ORF Names:mCG_2547Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:96067. Htt.

Subcellular locationi

GO - Cellular componenti

  1. autophagic vacuole Source: Ensembl
  2. axon Source: MGI
  3. cytoplasm Source: MGI
  4. cytoplasmic membrane-bounded vesicle Source: MGI
  5. cytoplasmic vesicle membrane Source: Ensembl
  6. cytosol Source: Ensembl
  7. dendrite Source: Ensembl
  8. endoplasmic reticulum Source: Ensembl
  9. Golgi apparatus Source: Ensembl
  10. inclusion body Source: MGI
  11. late endosome Source: Ensembl
  12. mitochondrion Source: GOC
  13. nucleus Source: RefGenome
  14. protein complex Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000015863.
KOiK04533.
OMAiSDQVFIG.
OrthoDBiEOG7JQBMD.
TreeFamiTF323608.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view]
PANTHERiPTHR10170. PTHR10170. 1 hit.
PfamiPF12372. DUF3652. 2 hits.
[Graphical view]
PRINTSiPR00375. HUNTINGTIN.
SUPFAMiSSF48371. SSF48371. 8 hits.

Sequencei

Sequence statusi: Complete.

G3X9H5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATLEKLMKA FESLKSFQQQ QQQQPPPQAP PPPPPPPPPQ PPQPPPQGQP
60 70 80 90 100
PPPPPPLPGP AEEPLHRPKK ELSATKKDRV NHCLTICENI VAQSLRNSPE
110 120 130 140 150
FQKLLGIAME LFLLCSDDAE SDVRMVADEC LNKVIKALMD SNLPRLQLEL
160 170 180 190 200
YKEIKKNGAP RSLRAALWRF AELAHLVRPQ KCRPYLVNLL PCLTRTSKRP
210 220 230 240 250
EESVQETLAA AVPKIMASFG NFANDNEIKV LLKAFIANLK SSSPTVRRTA
260 270 280 290 300
AGSAVSICQH SRRTQYFYNW LLNVLLGLLV PMEEEHSTLL ILGVLLTLRC
310 320 330 340 350
LVPLLQQQVK DTSLKGSFGV TRKEMEVSPS TEQLVQVYEL TLHHTQHQDH
360 370 380 390 400
NVVTGALELL QQLFRTPPPE LLQALTTPGG LGQLTLVQEE ARGRGRSGSI
410 420 430 440 450
VELLAGGGSS CSPVLSRKQK GKVLLGEEEA LEDDSESRSD VSSSAFAASV
460 470 480 490 500
KSEIGGELAA SSGVSTPGSV GHDIITEQPR SQHTLQADSV DLSGCDLTSA
510 520 530 540 550
ATDGDEEDIL SHSSSQFSAV PSDPAMDLND GTQASSPISD SSQTTTEGPD
560 570 580 590 600
SAVTPSDSSE IVLDGADSQY LGMQIGQPQE DDEEGAAGVL SGEVSDVFRN
610 620 630 640 650
SSLALQQAHL LERMGHSRQP SDSSIDKYVT RDEVAEASDP ESKPCRIKGD
660 670 680 690 700
IGQPNDDDSA PLVHCVRLLS ASFLLTGEKK ALVPDRDVRV SVKALALSCI
710 720 730 740 750
GAAVALHPES FFSRLYKVPL NTTESTEEQY VSDILNYIDH GDPQVRGATA
760 770 780 790 800
ILCGTLVYSI LSRSRLRVGD WLGNIRTLTG NTFSLVDCIP LLQKTLKDES
810 820 830 840 850
SVTCKLACTA VRHCVLSLCS SSYSDLGLQL LIDMLPLKNS SYWLVRTELL
860 870 880 890 900
DTLAEIDFRL VSFLEAKAES LHRGAHHYTG FLKLQERVLN NVVIYLLGDE
910 920 930 940 950
DPRVRHVAAT SLTRLVPKLF YKCDQGQADP VVAVARDQSS VYLKLLMHET
960 970 980 990 1000
QPPSHFSVST ITRIYRGYSL LPSITDVTME NNLSRVVAAV SHELITSTTR
1010 1020 1030 1040 1050
ALTFGCCEAL CLLSAAFPVC TWSLGWHCGV PPLSASDESR KSCTVGMASM
1060 1070 1080 1090 1100
ILTLLSSAWF PLDLSAHQDA LILAGNLLAA SAPKSLRSSW TSEEEANSAA
1110 1120 1130 1140 1150
TRQEEIWPAL GDRTLVPLVE QLFSHLLKVI NICAHVLDDV TPGPAIKAAL
1160 1170 1180 1190 1200
PSLTNPPSLS PIRRKGKEKE PGEQASTPMS PKKVGEASAA SRQSDTSGPV
1210 1220 1230 1240 1250
TASKSSSLGS FYHLPSYLKL HDVLKATHAN YKVTLDLQNS TEKFGGFLRS
1260 1270 1280 1290 1300
ALDVLSQILE LATLQDIGKC VEEVLGYLKS CFSREPMMAT VCVQQLLKTL
1310 1320 1330 1340 1350
FGTNLASQFD GLSSNPSKSQ CRAQRLGSSS VRPGLYHYCF MAPYTHFTQA
1360 1370 1380 1390 1400
LADASLRNMV QAEQERDASG WFDVLQKVSA QLKTNLTSVT KNRADKNAIH
1410 1420 1430 1440 1450
NHIRLFEPLV IKALKQYTTT TSVQLQKQVL DLLAQLVQLR VNYCLLDSDQ
1460 1470 1480 1490 1500
VFIGFVLKQF EYIEVGQFRE SEAIIPNIFF FLVLLSYERY HSKQIIGIPK
1510 1520 1530 1540 1550
IIQLCDGIMA SGRKAVTHAI PALQPIVHDL FVLRGTNKAD AGKELETQKE
1560 1570 1580 1590 1600
VVVSMLLRLI QYHQVLEMFI LVLQQCHKEN EDKWKRLSRQ VADIILPMLA
1610 1620 1630 1640 1650
KQQMHIDSHE ALGVLNTLFE ILAPSSLRPV DMLLRSMFIT PSTMASVSTV
1660 1670 1680 1690 1700
QLWISGILAI LRVLISQSTE DIVLCRIQEL SFSPHLLSCP VINRLRGGGG
1710 1720 1730 1740 1750
NVTLGECSEG KQKSLPEDTF SRFLLQLVGI LLEDIVTKQL KVDMSEQQHT
1760 1770 1780 1790 1800
FYCQELGTLL MCLIHIFKSG MFRRITAAAT RLFTSDGCEG SFYTLESLNA
1810 1820 1830 1840 1850
RVRSMVPTHP ALVLLWCQIL LLINHTDHRW WAEVQQTPKR HSLSCTKSLN
1860 1870 1880 1890 1900
PQKSGEEEDS GSAAQLGMCN REIVRRGALI LFCDYVCQNL HDSEHLTWLI
1910 1920 1930 1940 1950
VNHIQDLISL SHEPPVQDFI SAIHRNSAAS GLFIQAIQSR CENLSTPTTL
1960 1970 1980 1990 2000
KKTLQCLEGI HLSQSGAVLT LYVDRLLGTP FRALARMVDT LACRRVEMLL
2010 2020 2030 2040 2050
AANLQSSMAQ LPEEELNRIQ EHLQNSGLAQ RHQRLYSLLD RFRLSTVQDS
2060 2070 2080 2090 2100
LSPLPPVTSH PLDGDGHTSL ETVSPDKDWY LQLVRSQCWT RSDSALLEGA
2110 2120 2130 2140 2150
ELVNRIPAED MNDFMMSSEF NLSLLAPCLS LGMSEIANGQ KSPLFEAARG
2160 2170 2180 2190 2200
VILNRVTSVV QQLPAVHQVF QPFLPIEPTA YWNKLNDLLG DTTSYQSLTI
2210 2220 2230 2240 2250
LARALAQYLV VLSKVPAHLH LPPEKEGDTV KFVVMTVEAL SWHLIHEQIP
2260 2270 2280 2290 2300
LSLDLQAGLD CCCLALQVPG LWGVLSSPEY VTHACSLIHC VRFILEAIAV
2310 2320 2330 2340 2350
QPGDQLLGPE SRSHTPRAVR KEEVDSDIQN LSHVTSACEM VADMVESLQS
2360 2370 2380 2390 2400
VLALGHKRNS TLPSFLTAVL KNIVISLARL PLVNSYTRVP PLVWKLGWSP
2410 2420 2430 2440 2450
KPGGDFGTVF PEIPVEFLQE KEILKEFIYR INTLGWTNRT QFEETWATLL
2460 2470 2480 2490 2500
GVLVTQPLVM EQEESPPEED TERTQIHVLA VQAITSLVLS AMTVPVAGNP
2510 2520 2530 2540 2550
AVSCLEQQPR NKPLKALDTR FGRKLSMIRG IVEQEIQEMV SQRENTATHH
2560 2570 2580 2590 2600
SHQAWDPVPS LLPATTGALI SHDKLLLQIN PEREPGNMSY KLGQVSIHSV
2610 2620 2630 2640 2650
WLGNNITPLR EEEWDEEEEE ESDVPAPTSP PVSPVNSRKH RAGVDIHSCS
2660 2670 2680 2690 2700
QFLLELYSRW ILPSSAARRT PVILISEVVR SLLVVSDLFT ERTQFEMMYL
2710 2720 2730 2740 2750
TLTELRRVHP SEDEILIQYL VPATCKAAAV LGMDKTVAEP VSRLLESTLR
2760 2770 2780 2790 2800
SSHLPSQIGA LHGILYVLEC DLLDDTAKQL IPVVSDYLLS NLKGIAHCVN
2810 2820 2830 2840 2850
IHSQQHVLVM CATAFYLMEN YPLDVGPEFS ASVIQMCGVM LSGSEESTPS
2860 2870 2880 2890 2900
IIYHCALRGL ERLLLSEQLS RLDTESLVKL SVDRVNVQSP HRAMAALGLM
2910 2920 2930 2940 2950
LTCMYTGKEK ASPGRASDPS PATPDSESVI VAMERVSVLF DRIRKGFPCE
2960 2970 2980 2990 3000
ARVVARILPQ FLDDFFPPQD VMNKVIGEFL SNQQPYPQFM ATVVYKVFQT
3010 3020 3030 3040 3050
LHSAGQSSMV RDWVMLSLSN FTQRTPVAMA MWSLSCFLVS ASTSPWVSAI
3060 3070 3080 3090 3100
LPHVISRMGK LEQVDVNLFC LVATDFYRHQ IEEEFDRRAF QSVFEVVAAP
3110 3120
GSPYHRLLAC LQNVHKVTTC
Length:3,120
Mass (Da):344,788
Last modified:November 16, 2011 - v1
Checksum:i53CCDC45D53B8BA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC133204 Genomic DNA. No translation available.
AC151669 Genomic DNA. No translation available.
CH466524 Genomic DNA. Translation: EDL37467.1.
RefSeqiNP_034544.1. NM_010414.3.
UniGeneiMm.209071.

Genome annotation databases

EnsembliENSMUST00000080036; ENSMUSP00000078945; ENSMUSG00000029104.
GeneIDi15194.
KEGGimmu:15194.
UCSCiuc008xdc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC133204 Genomic DNA. No translation available.
AC151669 Genomic DNA. No translation available.
CH466524 Genomic DNA. Translation: EDL37467.1 .
RefSeqi NP_034544.1. NM_010414.3.
UniGenei Mm.209071.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080036 ; ENSMUSP00000078945 ; ENSMUSG00000029104 .
GeneIDi 15194.
KEGGi mmu:15194.
UCSCi uc008xdc.2. mouse.

Organism-specific databases

CTDi 3064.
MGIi MGI:96067. Htt.

Phylogenomic databases

GeneTreei ENSGT00390000015863.
KOi K04533.
OMAi SDQVFIG.
OrthoDBi EOG7JQBMD.
TreeFami TF323608.

Miscellaneous databases

ChiTaRSi HTT. mouse.
NextBioi 287727.
SOURCEi Search...

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view ]
PANTHERi PTHR10170. PTHR10170. 1 hit.
Pfami PF12372. DUF3652. 2 hits.
[Graphical view ]
PRINTSi PR00375. HUNTINGTIN.
SUPFAMi SSF48371. SSF48371. 8 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG3X9H5_MOUSE
AccessioniPrimary (citable) accession number: G3X9H5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3