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G3X9H5

- G3X9H5_MOUSE

UniProt

G3X9H5 - G3X9H5_MOUSE

Protein
Submitted name:

Huntingtin

Gene

Htt

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. diazepam binding Source: MGI
    2. protein binding Source: MGI
    3. transcription factor binding Source: MGI

    GO - Biological processi

    1. anatomical structure morphogenesis Source: MGI
    2. anterior/posterior pattern specification Source: MGI
    3. apoptotic process Source: MGI
    4. associative learning Source: MGI
    5. axon cargo transport Source: MGI
    6. brain development Source: MGI
    7. cell aging Source: MGI
    8. central nervous system development Source: MGI
    9. citrulline metabolic process Source: MGI
    10. determination of adult lifespan Source: MGI
    11. dopamine receptor signaling pathway Source: MGI
    12. endoplasmic reticulum organization Source: MGI
    13. endosomal transport Source: MGI
    14. ER to Golgi vesicle-mediated transport Source: MGI
    15. establishment of mitotic spindle orientation Source: Ensembl
    16. gastrulation Source: MGI
    17. Golgi organization Source: Ensembl
    18. grooming behavior Source: MGI
    19. hormone metabolic process Source: MGI
    20. insulin secretion Source: MGI
    21. iron ion homeostasis Source: MGI
    22. lactate biosynthetic process from pyruvate Source: MGI
    23. learning Source: MGI
    24. learning or memory Source: MGI
    25. L-glutamate import Source: MGI
    26. locomotory behavior Source: MGI
    27. mitochondrial transport Source: MGI
    28. mitochondrion organization Source: MGI
    29. negative regulation of apoptotic process Source: MGI
    30. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    31. negative regulation of neuron apoptotic process Source: MGI
    32. negative regulation of neuron death Source: MGI
    33. neural plate formation Source: MGI
    34. neurogenesis Source: MGI
    35. neuron apoptotic process Source: MGI
    36. neuron development Source: MGI
    37. olfactory lobe development Source: MGI
    38. paraxial mesoderm formation Source: MGI
    39. peptide hormone secretion Source: MGI
    40. protein import into nucleus Source: MGI
    41. quinolinate biosynthetic process Source: MGI
    42. regulation of mitochondrial membrane permeability Source: MGI
    43. regulation of mitochondrial membrane potential Source: MGI
    44. regulation of protein export from nucleus Source: Ensembl
    45. regulation of protein phosphatase type 2A activity Source: Ensembl
    46. regulation of synaptic plasticity Source: MGI
    47. response to calcium ion Source: MGI
    48. retrograde vesicle-mediated transport, Golgi to ER Source: Ensembl
    49. social behavior Source: MGI
    50. spermatogenesis Source: MGI
    51. striatum development Source: MGI
    52. urea cycle Source: MGI
    53. vesicle transport along microtubule Source: MGI
    54. visual learning Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    HuntingtinImported
    Submitted name:
    Huntington disease gene homolog, isoform CRA_aImported
    Gene namesi
    Name:HttImported
    Synonyms:HdhImported
    ORF Names:mCG_2547Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:96067. Htt.

    Subcellular locationi

    GO - Cellular componenti

    1. autophagic vacuole Source: Ensembl
    2. axon Source: MGI
    3. cytoplasm Source: MGI
    4. cytoplasmic membrane-bounded vesicle Source: MGI
    5. cytoplasmic vesicle membrane Source: Ensembl
    6. cytosol Source: Ensembl
    7. dendrite Source: Ensembl
    8. endoplasmic reticulum Source: Ensembl
    9. Golgi apparatus Source: Ensembl
    10. inclusion body Source: MGI
    11. late endosome Source: Ensembl
    12. mitochondrion Source: GOC
    13. nucleus Source: RefGenome
    14. protein complex Source: Ensembl

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000015863.
    KOiK04533.
    OMAiSDQVFIG.
    OrthoDBiEOG7JQBMD.
    TreeFamiTF323608.

    Family and domain databases

    Gene3Di1.25.10.10. 4 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000091. Huntingtin.
    IPR028426. Huntingtin_fam.
    IPR024613. Huntingtin_middle-repeat.
    [Graphical view]
    PANTHERiPTHR10170. PTHR10170. 1 hit.
    PfamiPF12372. DUF3652. 2 hits.
    [Graphical view]
    PRINTSiPR00375. HUNTINGTIN.
    SUPFAMiSSF48371. SSF48371. 8 hits.

    Sequencei

    Sequence statusi: Complete.

    G3X9H5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATLEKLMKA FESLKSFQQQ QQQQPPPQAP PPPPPPPPPQ PPQPPPQGQP     50
    PPPPPPLPGP AEEPLHRPKK ELSATKKDRV NHCLTICENI VAQSLRNSPE 100
    FQKLLGIAME LFLLCSDDAE SDVRMVADEC LNKVIKALMD SNLPRLQLEL 150
    YKEIKKNGAP RSLRAALWRF AELAHLVRPQ KCRPYLVNLL PCLTRTSKRP 200
    EESVQETLAA AVPKIMASFG NFANDNEIKV LLKAFIANLK SSSPTVRRTA 250
    AGSAVSICQH SRRTQYFYNW LLNVLLGLLV PMEEEHSTLL ILGVLLTLRC 300
    LVPLLQQQVK DTSLKGSFGV TRKEMEVSPS TEQLVQVYEL TLHHTQHQDH 350
    NVVTGALELL QQLFRTPPPE LLQALTTPGG LGQLTLVQEE ARGRGRSGSI 400
    VELLAGGGSS CSPVLSRKQK GKVLLGEEEA LEDDSESRSD VSSSAFAASV 450
    KSEIGGELAA SSGVSTPGSV GHDIITEQPR SQHTLQADSV DLSGCDLTSA 500
    ATDGDEEDIL SHSSSQFSAV PSDPAMDLND GTQASSPISD SSQTTTEGPD 550
    SAVTPSDSSE IVLDGADSQY LGMQIGQPQE DDEEGAAGVL SGEVSDVFRN 600
    SSLALQQAHL LERMGHSRQP SDSSIDKYVT RDEVAEASDP ESKPCRIKGD 650
    IGQPNDDDSA PLVHCVRLLS ASFLLTGEKK ALVPDRDVRV SVKALALSCI 700
    GAAVALHPES FFSRLYKVPL NTTESTEEQY VSDILNYIDH GDPQVRGATA 750
    ILCGTLVYSI LSRSRLRVGD WLGNIRTLTG NTFSLVDCIP LLQKTLKDES 800
    SVTCKLACTA VRHCVLSLCS SSYSDLGLQL LIDMLPLKNS SYWLVRTELL 850
    DTLAEIDFRL VSFLEAKAES LHRGAHHYTG FLKLQERVLN NVVIYLLGDE 900
    DPRVRHVAAT SLTRLVPKLF YKCDQGQADP VVAVARDQSS VYLKLLMHET 950
    QPPSHFSVST ITRIYRGYSL LPSITDVTME NNLSRVVAAV SHELITSTTR 1000
    ALTFGCCEAL CLLSAAFPVC TWSLGWHCGV PPLSASDESR KSCTVGMASM 1050
    ILTLLSSAWF PLDLSAHQDA LILAGNLLAA SAPKSLRSSW TSEEEANSAA 1100
    TRQEEIWPAL GDRTLVPLVE QLFSHLLKVI NICAHVLDDV TPGPAIKAAL 1150
    PSLTNPPSLS PIRRKGKEKE PGEQASTPMS PKKVGEASAA SRQSDTSGPV 1200
    TASKSSSLGS FYHLPSYLKL HDVLKATHAN YKVTLDLQNS TEKFGGFLRS 1250
    ALDVLSQILE LATLQDIGKC VEEVLGYLKS CFSREPMMAT VCVQQLLKTL 1300
    FGTNLASQFD GLSSNPSKSQ CRAQRLGSSS VRPGLYHYCF MAPYTHFTQA 1350
    LADASLRNMV QAEQERDASG WFDVLQKVSA QLKTNLTSVT KNRADKNAIH 1400
    NHIRLFEPLV IKALKQYTTT TSVQLQKQVL DLLAQLVQLR VNYCLLDSDQ 1450
    VFIGFVLKQF EYIEVGQFRE SEAIIPNIFF FLVLLSYERY HSKQIIGIPK 1500
    IIQLCDGIMA SGRKAVTHAI PALQPIVHDL FVLRGTNKAD AGKELETQKE 1550
    VVVSMLLRLI QYHQVLEMFI LVLQQCHKEN EDKWKRLSRQ VADIILPMLA 1600
    KQQMHIDSHE ALGVLNTLFE ILAPSSLRPV DMLLRSMFIT PSTMASVSTV 1650
    QLWISGILAI LRVLISQSTE DIVLCRIQEL SFSPHLLSCP VINRLRGGGG 1700
    NVTLGECSEG KQKSLPEDTF SRFLLQLVGI LLEDIVTKQL KVDMSEQQHT 1750
    FYCQELGTLL MCLIHIFKSG MFRRITAAAT RLFTSDGCEG SFYTLESLNA 1800
    RVRSMVPTHP ALVLLWCQIL LLINHTDHRW WAEVQQTPKR HSLSCTKSLN 1850
    PQKSGEEEDS GSAAQLGMCN REIVRRGALI LFCDYVCQNL HDSEHLTWLI 1900
    VNHIQDLISL SHEPPVQDFI SAIHRNSAAS GLFIQAIQSR CENLSTPTTL 1950
    KKTLQCLEGI HLSQSGAVLT LYVDRLLGTP FRALARMVDT LACRRVEMLL 2000
    AANLQSSMAQ LPEEELNRIQ EHLQNSGLAQ RHQRLYSLLD RFRLSTVQDS 2050
    LSPLPPVTSH PLDGDGHTSL ETVSPDKDWY LQLVRSQCWT RSDSALLEGA 2100
    ELVNRIPAED MNDFMMSSEF NLSLLAPCLS LGMSEIANGQ KSPLFEAARG 2150
    VILNRVTSVV QQLPAVHQVF QPFLPIEPTA YWNKLNDLLG DTTSYQSLTI 2200
    LARALAQYLV VLSKVPAHLH LPPEKEGDTV KFVVMTVEAL SWHLIHEQIP 2250
    LSLDLQAGLD CCCLALQVPG LWGVLSSPEY VTHACSLIHC VRFILEAIAV 2300
    QPGDQLLGPE SRSHTPRAVR KEEVDSDIQN LSHVTSACEM VADMVESLQS 2350
    VLALGHKRNS TLPSFLTAVL KNIVISLARL PLVNSYTRVP PLVWKLGWSP 2400
    KPGGDFGTVF PEIPVEFLQE KEILKEFIYR INTLGWTNRT QFEETWATLL 2450
    GVLVTQPLVM EQEESPPEED TERTQIHVLA VQAITSLVLS AMTVPVAGNP 2500
    AVSCLEQQPR NKPLKALDTR FGRKLSMIRG IVEQEIQEMV SQRENTATHH 2550
    SHQAWDPVPS LLPATTGALI SHDKLLLQIN PEREPGNMSY KLGQVSIHSV 2600
    WLGNNITPLR EEEWDEEEEE ESDVPAPTSP PVSPVNSRKH RAGVDIHSCS 2650
    QFLLELYSRW ILPSSAARRT PVILISEVVR SLLVVSDLFT ERTQFEMMYL 2700
    TLTELRRVHP SEDEILIQYL VPATCKAAAV LGMDKTVAEP VSRLLESTLR 2750
    SSHLPSQIGA LHGILYVLEC DLLDDTAKQL IPVVSDYLLS NLKGIAHCVN 2800
    IHSQQHVLVM CATAFYLMEN YPLDVGPEFS ASVIQMCGVM LSGSEESTPS 2850
    IIYHCALRGL ERLLLSEQLS RLDTESLVKL SVDRVNVQSP HRAMAALGLM 2900
    LTCMYTGKEK ASPGRASDPS PATPDSESVI VAMERVSVLF DRIRKGFPCE 2950
    ARVVARILPQ FLDDFFPPQD VMNKVIGEFL SNQQPYPQFM ATVVYKVFQT 3000
    LHSAGQSSMV RDWVMLSLSN FTQRTPVAMA MWSLSCFLVS ASTSPWVSAI 3050
    LPHVISRMGK LEQVDVNLFC LVATDFYRHQ IEEEFDRRAF QSVFEVVAAP 3100
    GSPYHRLLAC LQNVHKVTTC 3120
    Length:3,120
    Mass (Da):344,788
    Last modified:November 16, 2011 - v1
    Checksum:i53CCDC45D53B8BA3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC133204 Genomic DNA. No translation available.
    AC151669 Genomic DNA. No translation available.
    CH466524 Genomic DNA. Translation: EDL37467.1.
    RefSeqiNP_034544.1. NM_010414.3.
    UniGeneiMm.209071.

    Genome annotation databases

    EnsembliENSMUST00000080036; ENSMUSP00000078945; ENSMUSG00000029104.
    GeneIDi15194.
    KEGGimmu:15194.
    UCSCiuc008xdc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC133204 Genomic DNA. No translation available.
    AC151669 Genomic DNA. No translation available.
    CH466524 Genomic DNA. Translation: EDL37467.1 .
    RefSeqi NP_034544.1. NM_010414.3.
    UniGenei Mm.209071.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000080036 ; ENSMUSP00000078945 ; ENSMUSG00000029104 .
    GeneIDi 15194.
    KEGGi mmu:15194.
    UCSCi uc008xdc.2. mouse.

    Organism-specific databases

    CTDi 3064.
    MGIi MGI:96067. Htt.

    Phylogenomic databases

    GeneTreei ENSGT00390000015863.
    KOi K04533.
    OMAi SDQVFIG.
    OrthoDBi EOG7JQBMD.
    TreeFami TF323608.

    Miscellaneous databases

    ChiTaRSi HTT. mouse.
    NextBioi 287727.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.25.10.10. 4 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR000091. Huntingtin.
    IPR028426. Huntingtin_fam.
    IPR024613. Huntingtin_middle-repeat.
    [Graphical view ]
    PANTHERi PTHR10170. PTHR10170. 1 hit.
    Pfami PF12372. DUF3652. 2 hits.
    [Graphical view ]
    PRINTSi PR00375. HUNTINGTIN.
    SUPFAMi SSF48371. SSF48371. 8 hits.
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    5. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiG3X9H5_MOUSE
    AccessioniPrimary (citable) accession number: G3X9H5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3