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G3X9H5

- G3X9H5_MOUSE

UniProt

G3X9H5 - G3X9H5_MOUSE

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Protein
Submitted name:

Huntingtin

Gene
Htt, Hdh, mCG_2547
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. diazepam binding Source: MGI
  2. protein binding Source: MGI
  3. transcription factor binding Source: MGI

GO - Biological processi

  1. anatomical structure morphogenesis Source: MGI
  2. anterior/posterior pattern specification Source: MGI
  3. apoptotic process Source: MGI
  4. associative learning Source: MGI
  5. axon cargo transport Source: MGI
  6. brain development Source: MGI
  7. cell aging Source: MGI
  8. central nervous system development Source: MGI
  9. citrulline metabolic process Source: MGI
  10. determination of adult lifespan Source: MGI
  11. dopamine receptor signaling pathway Source: MGI
  12. endoplasmic reticulum organization Source: MGI
  13. endosomal transport Source: MGI
  14. ER to Golgi vesicle-mediated transport Source: MGI
  15. establishment of mitotic spindle orientation Source: Ensembl
  16. gastrulation Source: MGI
  17. Golgi organization Source: Ensembl
  18. grooming behavior Source: MGI
  19. hormone metabolic process Source: MGI
  20. insulin secretion Source: MGI
  21. iron ion homeostasis Source: MGI
  22. lactate biosynthetic process from pyruvate Source: MGI
  23. learning Source: MGI
  24. learning or memory Source: MGI
  25. L-glutamate import Source: MGI
  26. locomotory behavior Source: MGI
  27. mitochondrial transport Source: MGI
  28. mitochondrion organization Source: MGI
  29. negative regulation of apoptotic process Source: MGI
  30. negative regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  31. negative regulation of neuron apoptotic process Source: MGI
  32. negative regulation of neuron death Source: MGI
  33. neural plate formation Source: MGI
  34. neurogenesis Source: MGI
  35. neuron apoptotic process Source: MGI
  36. neuron development Source: MGI
  37. olfactory lobe development Source: MGI
  38. paraxial mesoderm formation Source: MGI
  39. peptide hormone secretion Source: MGI
  40. protein import into nucleus Source: MGI
  41. quinolinate biosynthetic process Source: MGI
  42. regulation of mitochondrial membrane permeability Source: MGI
  43. regulation of mitochondrial membrane potential Source: MGI
  44. regulation of protein export from nucleus Source: Ensembl
  45. regulation of protein phosphatase type 2A activity Source: Ensembl
  46. regulation of synaptic plasticity Source: MGI
  47. response to calcium ion Source: MGI
  48. retrograde vesicle-mediated transport, Golgi to ER Source: Ensembl
  49. social behavior Source: MGI
  50. spermatogenesis Source: MGI
  51. striatum development Source: MGI
  52. urea cycle Source: MGI
  53. vesicle transport along microtubule Source: MGI
  54. visual learning Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
HuntingtinImported
Submitted name:
Huntington disease gene homolog, isoform CRA_aImported
Gene namesi
Name:HttImported
Synonyms:HdhImported
ORF Names:mCG_2547Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:96067. Htt.

Subcellular locationi

GO - Cellular componenti

  1. autophagic vacuole Source: Ensembl
  2. axon Source: MGI
  3. cytoplasm Source: MGI
  4. cytoplasmic membrane-bounded vesicle Source: MGI
  5. cytoplasmic vesicle membrane Source: Ensembl
  6. cytosol Source: Ensembl
  7. dendrite Source: Ensembl
  8. endoplasmic reticulum Source: Ensembl
  9. Golgi apparatus Source: Ensembl
  10. inclusion body Source: MGI
  11. late endosome Source: Ensembl
  12. mitochondrion Source: GOC
  13. nucleus Source: RefGenome
  14. protein complex Source: Ensembl
Complete GO annotation...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000015863.
KOiK04533.
OMAiSDQVFIG.
OrthoDBiEOG7JQBMD.
TreeFamiTF323608.

Family and domain databases

Gene3Di1.25.10.10. 4 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view]
PANTHERiPTHR10170. PTHR10170. 1 hit.
PfamiPF12372. DUF3652. 2 hits.
[Graphical view]
PRINTSiPR00375. HUNTINGTIN.
SUPFAMiSSF48371. SSF48371. 8 hits.

Sequencei

Sequence statusi: Complete.

G3X9H5-1 [UniParc]FASTAAdd to Basket

« Hide

MATLEKLMKA FESLKSFQQQ QQQQPPPQAP PPPPPPPPPQ PPQPPPQGQP     50
PPPPPPLPGP AEEPLHRPKK ELSATKKDRV NHCLTICENI VAQSLRNSPE 100
FQKLLGIAME LFLLCSDDAE SDVRMVADEC LNKVIKALMD SNLPRLQLEL 150
YKEIKKNGAP RSLRAALWRF AELAHLVRPQ KCRPYLVNLL PCLTRTSKRP 200
EESVQETLAA AVPKIMASFG NFANDNEIKV LLKAFIANLK SSSPTVRRTA 250
AGSAVSICQH SRRTQYFYNW LLNVLLGLLV PMEEEHSTLL ILGVLLTLRC 300
LVPLLQQQVK DTSLKGSFGV TRKEMEVSPS TEQLVQVYEL TLHHTQHQDH 350
NVVTGALELL QQLFRTPPPE LLQALTTPGG LGQLTLVQEE ARGRGRSGSI 400
VELLAGGGSS CSPVLSRKQK GKVLLGEEEA LEDDSESRSD VSSSAFAASV 450
KSEIGGELAA SSGVSTPGSV GHDIITEQPR SQHTLQADSV DLSGCDLTSA 500
ATDGDEEDIL SHSSSQFSAV PSDPAMDLND GTQASSPISD SSQTTTEGPD 550
SAVTPSDSSE IVLDGADSQY LGMQIGQPQE DDEEGAAGVL SGEVSDVFRN 600
SSLALQQAHL LERMGHSRQP SDSSIDKYVT RDEVAEASDP ESKPCRIKGD 650
IGQPNDDDSA PLVHCVRLLS ASFLLTGEKK ALVPDRDVRV SVKALALSCI 700
GAAVALHPES FFSRLYKVPL NTTESTEEQY VSDILNYIDH GDPQVRGATA 750
ILCGTLVYSI LSRSRLRVGD WLGNIRTLTG NTFSLVDCIP LLQKTLKDES 800
SVTCKLACTA VRHCVLSLCS SSYSDLGLQL LIDMLPLKNS SYWLVRTELL 850
DTLAEIDFRL VSFLEAKAES LHRGAHHYTG FLKLQERVLN NVVIYLLGDE 900
DPRVRHVAAT SLTRLVPKLF YKCDQGQADP VVAVARDQSS VYLKLLMHET 950
QPPSHFSVST ITRIYRGYSL LPSITDVTME NNLSRVVAAV SHELITSTTR 1000
ALTFGCCEAL CLLSAAFPVC TWSLGWHCGV PPLSASDESR KSCTVGMASM 1050
ILTLLSSAWF PLDLSAHQDA LILAGNLLAA SAPKSLRSSW TSEEEANSAA 1100
TRQEEIWPAL GDRTLVPLVE QLFSHLLKVI NICAHVLDDV TPGPAIKAAL 1150
PSLTNPPSLS PIRRKGKEKE PGEQASTPMS PKKVGEASAA SRQSDTSGPV 1200
TASKSSSLGS FYHLPSYLKL HDVLKATHAN YKVTLDLQNS TEKFGGFLRS 1250
ALDVLSQILE LATLQDIGKC VEEVLGYLKS CFSREPMMAT VCVQQLLKTL 1300
FGTNLASQFD GLSSNPSKSQ CRAQRLGSSS VRPGLYHYCF MAPYTHFTQA 1350
LADASLRNMV QAEQERDASG WFDVLQKVSA QLKTNLTSVT KNRADKNAIH 1400
NHIRLFEPLV IKALKQYTTT TSVQLQKQVL DLLAQLVQLR VNYCLLDSDQ 1450
VFIGFVLKQF EYIEVGQFRE SEAIIPNIFF FLVLLSYERY HSKQIIGIPK 1500
IIQLCDGIMA SGRKAVTHAI PALQPIVHDL FVLRGTNKAD AGKELETQKE 1550
VVVSMLLRLI QYHQVLEMFI LVLQQCHKEN EDKWKRLSRQ VADIILPMLA 1600
KQQMHIDSHE ALGVLNTLFE ILAPSSLRPV DMLLRSMFIT PSTMASVSTV 1650
QLWISGILAI LRVLISQSTE DIVLCRIQEL SFSPHLLSCP VINRLRGGGG 1700
NVTLGECSEG KQKSLPEDTF SRFLLQLVGI LLEDIVTKQL KVDMSEQQHT 1750
FYCQELGTLL MCLIHIFKSG MFRRITAAAT RLFTSDGCEG SFYTLESLNA 1800
RVRSMVPTHP ALVLLWCQIL LLINHTDHRW WAEVQQTPKR HSLSCTKSLN 1850
PQKSGEEEDS GSAAQLGMCN REIVRRGALI LFCDYVCQNL HDSEHLTWLI 1900
VNHIQDLISL SHEPPVQDFI SAIHRNSAAS GLFIQAIQSR CENLSTPTTL 1950
KKTLQCLEGI HLSQSGAVLT LYVDRLLGTP FRALARMVDT LACRRVEMLL 2000
AANLQSSMAQ LPEEELNRIQ EHLQNSGLAQ RHQRLYSLLD RFRLSTVQDS 2050
LSPLPPVTSH PLDGDGHTSL ETVSPDKDWY LQLVRSQCWT RSDSALLEGA 2100
ELVNRIPAED MNDFMMSSEF NLSLLAPCLS LGMSEIANGQ KSPLFEAARG 2150
VILNRVTSVV QQLPAVHQVF QPFLPIEPTA YWNKLNDLLG DTTSYQSLTI 2200
LARALAQYLV VLSKVPAHLH LPPEKEGDTV KFVVMTVEAL SWHLIHEQIP 2250
LSLDLQAGLD CCCLALQVPG LWGVLSSPEY VTHACSLIHC VRFILEAIAV 2300
QPGDQLLGPE SRSHTPRAVR KEEVDSDIQN LSHVTSACEM VADMVESLQS 2350
VLALGHKRNS TLPSFLTAVL KNIVISLARL PLVNSYTRVP PLVWKLGWSP 2400
KPGGDFGTVF PEIPVEFLQE KEILKEFIYR INTLGWTNRT QFEETWATLL 2450
GVLVTQPLVM EQEESPPEED TERTQIHVLA VQAITSLVLS AMTVPVAGNP 2500
AVSCLEQQPR NKPLKALDTR FGRKLSMIRG IVEQEIQEMV SQRENTATHH 2550
SHQAWDPVPS LLPATTGALI SHDKLLLQIN PEREPGNMSY KLGQVSIHSV 2600
WLGNNITPLR EEEWDEEEEE ESDVPAPTSP PVSPVNSRKH RAGVDIHSCS 2650
QFLLELYSRW ILPSSAARRT PVILISEVVR SLLVVSDLFT ERTQFEMMYL 2700
TLTELRRVHP SEDEILIQYL VPATCKAAAV LGMDKTVAEP VSRLLESTLR 2750
SSHLPSQIGA LHGILYVLEC DLLDDTAKQL IPVVSDYLLS NLKGIAHCVN 2800
IHSQQHVLVM CATAFYLMEN YPLDVGPEFS ASVIQMCGVM LSGSEESTPS 2850
IIYHCALRGL ERLLLSEQLS RLDTESLVKL SVDRVNVQSP HRAMAALGLM 2900
LTCMYTGKEK ASPGRASDPS PATPDSESVI VAMERVSVLF DRIRKGFPCE 2950
ARVVARILPQ FLDDFFPPQD VMNKVIGEFL SNQQPYPQFM ATVVYKVFQT 3000
LHSAGQSSMV RDWVMLSLSN FTQRTPVAMA MWSLSCFLVS ASTSPWVSAI 3050
LPHVISRMGK LEQVDVNLFC LVATDFYRHQ IEEEFDRRAF QSVFEVVAAP 3100
GSPYHRLLAC LQNVHKVTTC 3120
Length:3,120
Mass (Da):344,788
Last modified:November 16, 2011 - v1
Checksum:i53CCDC45D53B8BA3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC133204 Genomic DNA. No translation available.
AC151669 Genomic DNA. No translation available.
CH466524 Genomic DNA. Translation: EDL37467.1.
RefSeqiNP_034544.1. NM_010414.3.
UniGeneiMm.209071.

Genome annotation databases

EnsembliENSMUST00000080036; ENSMUSP00000078945; ENSMUSG00000029104.
GeneIDi15194.
KEGGimmu:15194.
UCSCiuc008xdc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC133204 Genomic DNA. No translation available.
AC151669 Genomic DNA. No translation available.
CH466524 Genomic DNA. Translation: EDL37467.1 .
RefSeqi NP_034544.1. NM_010414.3.
UniGenei Mm.209071.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000080036 ; ENSMUSP00000078945 ; ENSMUSG00000029104 .
GeneIDi 15194.
KEGGi mmu:15194.
UCSCi uc008xdc.2. mouse.

Organism-specific databases

CTDi 3064.
MGIi MGI:96067. Htt.

Phylogenomic databases

GeneTreei ENSGT00390000015863.
KOi K04533.
OMAi SDQVFIG.
OrthoDBi EOG7JQBMD.
TreeFami TF323608.

Miscellaneous databases

ChiTaRSi HTT. mouse.
NextBioi 287727.
SOURCEi Search...

Family and domain databases

Gene3Di 1.25.10.10. 4 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000091. Huntingtin.
IPR028426. Huntingtin_fam.
IPR024613. Huntingtin_middle-repeat.
[Graphical view ]
PANTHERi PTHR10170. PTHR10170. 1 hit.
Pfami PF12372. DUF3652. 2 hits.
[Graphical view ]
PRINTSi PR00375. HUNTINGTIN.
SUPFAMi SSF48371. SSF48371. 8 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  5. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG3X9H5_MOUSE
AccessioniPrimary (citable) accession number: G3X9H5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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