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Protein
Submitted name:

Luteinizing hormone beta

Gene

Lhb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

Keywords - Molecular functioni

HormoneUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-193048. Androgen biosynthesis.
R-MMU-193993. Mineralocorticoid biosynthesis.
R-MMU-209822. Glycoprotein hormones.
R-MMU-375281. Hormone ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-MMU-975578. Reactions specific to the complex N-glycan synthesis pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Luteinizing hormone betaImported
Submitted name:
Luteinizing hormone beta subunitImported
Submitted name:
Lutropin subunit betaImported
Gene namesi
Name:LhbImported
ORF Names:mCG_23164Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96782. Lhb.

Subcellular locationi

  • Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500876220721 – 141Sequence analysisAdd BLAST121

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000038194.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072276.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 130Cys_knotInterPro annotationAdd BLAST104

Sequence similaritiesi

Belongs to the glycoprotein hormones subunit beta family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
KOiK08521.
OMAiCRCGPCR.
OrthoDBiEOG091G0XFH.
TreeFamiTF332940.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3X9G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERLQGLLLW LLLSPSVVWA SRGPLRPLCR PVNATLAAEN EFCPVCITFT
60 70 80 90 100
TSICAGYCPS MVRVLPAALP PVPQPVCTYR ELRFASVRLP GCPPGVDPIV
110 120 130 140
SFPVALSCRC GPCRLSSSDC GGPRTQPMAC DLPHLPGLLL L
Length:141
Mass (Da):15,113
Last modified:November 16, 2011 - v1
Checksum:i5E996FB8F32E83BF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151602 Genomic DNA. No translation available.
HF564719 Genomic DNA. Translation: CCP37924.1.
CH466603 Genomic DNA. Translation: EDL22853.1.
RefSeqiNP_032523.2. NM_008497.2.
XP_011249112.1. XM_011250810.2.
UniGeneiMm.57061.

Genome annotation databases

EnsembliENSMUST00000072453; ENSMUSP00000072276; ENSMUSG00000100916.
GeneIDi16866.
KEGGimmu:16866.
UCSCiuc009gvb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC151602 Genomic DNA. No translation available.
HF564719 Genomic DNA. Translation: CCP37924.1.
CH466603 Genomic DNA. Translation: EDL22853.1.
RefSeqiNP_032523.2. NM_008497.2.
XP_011249112.1. XM_011250810.2.
UniGeneiMm.57061.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000072276.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072453; ENSMUSP00000072276; ENSMUSG00000100916.
GeneIDi16866.
KEGGimmu:16866.
UCSCiuc009gvb.1. mouse.

Organism-specific databases

CTDi3972.
MGIiMGI:96782. Lhb.

Phylogenomic databases

eggNOGiENOG410J0DB. Eukaryota.
ENOG4111ZSU. LUCA.
GeneTreeiENSGT00390000010115.
KOiK08521.
OMAiCRCGPCR.
OrthoDBiEOG091G0XFH.
TreeFamiTF332940.

Enzyme and pathway databases

ReactomeiR-MMU-193048. Androgen biosynthesis.
R-MMU-193993. Mineralocorticoid biosynthesis.
R-MMU-209822. Glycoprotein hormones.
R-MMU-375281. Hormone ligand-binding receptors.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-MMU-975578. Reactions specific to the complex N-glycan synthesis pathway.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000038194.

Family and domain databases

CDDicd00069. GHB_like. 1 hit.
Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR006208. Glyco_hormone_CN.
IPR001545. Gonadotropin_bsu.
IPR018245. Gonadotropin_bsu_CS.
[Graphical view]
PANTHERiPTHR11515. PTHR11515. 1 hit.
PfamiPF00007. Cys_knot. 1 hit.
[Graphical view]
SMARTiSM00068. GHB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00261. GLYCO_HORMONE_BETA_1. 1 hit.
PS00689. GLYCO_HORMONE_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3X9G6_MOUSE
AccessioniPrimary (citable) accession number: G3X9G6
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 30, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.