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Protein

Metalloendopeptidase

Gene

Tll1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi240Zinc; catalyticUniRule annotation1
Active sitei241UniRule annotation1
Metal bindingi244Zinc; catalyticUniRule annotation1
Metal bindingi250Zinc; catalyticUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, MetalloproteaseUniRule annotation, Protease

Keywords - Ligandi

Metal-bindingUniRule annotationSAAS annotation, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

ReactomeiR-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.
R-MMU-2214320. Anchoring fibril formation.
R-MMU-2243919. Crosslinking of collagen fibrils.

Names & Taxonomyi

Protein namesi
Recommended name:
MetalloendopeptidaseUniRule annotation (EC:3.4.24.-UniRule annotation)
Gene namesi
Name:Tll1Imported
ORF Names:mCG_22897Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:106923. Tll1.

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000053626.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070560.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini349 – 461CUBInterPro annotationAdd BLAST113
Domaini462 – 574CUBInterPro annotationAdd BLAST113
Domaini574 – 615EGF-likeInterPro annotationAdd BLAST42
Domaini618 – 730CUBInterPro annotationAdd BLAST113
Domaini730 – 770EGF-likeInterPro annotationAdd BLAST41
Domaini774 – 886CUBInterPro annotationAdd BLAST113
Domaini887 – 1003CUBInterPro annotationAdd BLAST117

Sequence similaritiesi

Belongs to the peptidase M12A family.UniRule annotationSAAS annotation
Contains 2 EGF-like domains.UniRule annotation
Contains 5 CUB domains.UniRule annotation

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119018.
KOiK09608.
OMAiGHFCGYD.
OrthoDBiEOG091G009U.
TreeFamiTF314351.

Family and domain databases

CDDicd00041. CUB. 5 hits.
Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3X9F5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLQALSPRM LLWLVVSGIV FSRVLWVCAG LDYDYTFDGN EEDKTEPIDY
60 70 80 90 100
KDPCKAAVFW GDIALDDEDL NIFQIDRTID LTQSPFGKLG HITGGFGDHG
110 120 130 140 150
MPKKRGALYQ LIERIRRIGS GLEQNNTMKG KAPPKLSEQS EKNRVPRAAT
160 170 180 190 200
SRTERIWPGG VIPYVIGGNF TGSQRAMFKQ AMRHWEKHTC VTFTERSDEE
210 220 230 240 250
SYIVFTYRPC GCCSYVGRRG NGPQAISIGK NCDKFGIVVH ELGHVIGFWH
260 270 280 290 300
EHTRPDRDNH VTIIRENIQP GQEYNFLKME PGEVNSLGER YDFDSIMHYA
310 320 330 340 350
RNTFSRGMFL DTILPSRDDN GIRPAIGQRT RLSKGDIAQA RKLYRCPACG
360 370 380 390 400
ETLQESSGNL SSPGFPNGYP SYTHCIWRVS VTPGEKIVLN FTTMDLYKSS
410 420 430 440 450
LCWYDYIEVR DGYWRKSPLL GRFCGDKVAG VLTSTDSRMW IEFRSSSNWV
460 470 480 490 500
GKGFAAVYEA ICGGEIRKNE GQIQSPNYPD DYRPMKECVW KIMVSEGYHV
510 520 530 540 550
GLTFQAFEIE RHDSCAYDHL EVRDGASENS PLIGRFCGYD KPEDIRSTSN
560 570 580 590 600
TLWMKFVSDG TVNKAGFAAN FFKEEDECAK PDRGGCEQRC LNTLGSYQCA
610 620 630 640 650
CEPGYELGPD RRSCEAACGG LLTKLNGTIT TPGWPKEYPP NKNCVWQVIA
660 670 680 690 700
PSQYRISVKF EFFELEGNEV CKYDYVEIWS GLSSESKLHG KFCGADIPEV
710 720 730 740 750
MTSHFNNMRI EFKSDNTVSK KGFKAHFFSD KDECSKDNGG CQHECVNTMG
760 770 780 790 800
SYTCQCRNGF VLHENKHDCK EAECEQKIHS PSGLITSPNW PDKYPSRKEC
810 820 830 840 850
TWVISAIPGH RITLAFNEFE VEQHQECAYD HLEIFDGETE KSPILGRLCG
860 870 880 890 900
SKIPDPLMAT GNEMFIRFIS DASVQRKGFQ ATHSTECGGR LKAESKPRDL
910 920 930 940 950
YSHAQFGDNN YPGQLDCEWL LVSERGSRLE LSFQTFEVEE EADCGYDYVE
960 970 980 990 1000
VFDGLSSKAV GLGRFCGSGP PEEIYSIGDV ALIHFHTDDT INKKGFYIRY
1010
KSIRYPETMH AKN
Length:1,013
Mass (Da):114,549
Last modified:November 16, 2011 - v1
Checksum:iAAC04489B5500ADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110622 Genomic DNA. No translation available.
AC147185 Genomic DNA. No translation available.
AC149051 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28671.1.
RefSeqiNP_033416.2. NM_009390.2.
UniGeneiMm.418367.
Mm.438712.

Genome annotation databases

EnsembliENSMUST00000066166; ENSMUSP00000070560; ENSMUSG00000053626.
GeneIDi21892.
KEGGimmu:21892.
UCSCiuc009lut.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110622 Genomic DNA. No translation available.
AC147185 Genomic DNA. No translation available.
AC149051 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28671.1.
RefSeqiNP_033416.2. NM_009390.2.
UniGeneiMm.418367.
Mm.438712.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000070560.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066166; ENSMUSP00000070560; ENSMUSG00000053626.
GeneIDi21892.
KEGGimmu:21892.
UCSCiuc009lut.1. mouse.

Organism-specific databases

CTDi7092.
MGIiMGI:106923. Tll1.

Phylogenomic databases

eggNOGiKOG3714. Eukaryota.
ENOG410ZPX7. LUCA.
GeneTreeiENSGT00760000119018.
KOiK09608.
OMAiGHFCGYD.
OrthoDBiEOG091G009U.
TreeFamiTF314351.

Enzyme and pathway databases

ReactomeiR-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-1650814. Collagen biosynthesis and modifying enzymes.
R-MMU-2214320. Anchoring fibril formation.
R-MMU-2243919. Crosslinking of collagen fibrils.

Miscellaneous databases

ChiTaRSiTll1. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053626.

Family and domain databases

CDDicd00041. CUB. 5 hits.
Gene3Di2.60.120.290. 5 hits.
3.40.390.10. 1 hit.
InterProiIPR015446. BMP_1/tolloid-like.
IPR000859. CUB_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024079. MetalloPept_cat_dom.
IPR001506. Peptidase_M12A.
IPR006026. Peptidase_Metallo.
[Graphical view]
PfamiPF01400. Astacin. 1 hit.
PF00431. CUB. 5 hits.
[Graphical view]
PIRSFiPIRSF001199. BMP_1/tolloid-like. 1 hit.
PRINTSiPR00480. ASTACIN.
SMARTiSM00042. CUB. 5 hits.
SM00181. EGF. 2 hits.
SM00179. EGF_CA. 2 hits.
SM00235. ZnMc. 1 hit.
[Graphical view]
SUPFAMiSSF49854. SSF49854. 5 hits.
PROSITEiPS00010. ASX_HYDROXYL. 2 hits.
PS01180. CUB. 5 hits.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3X9F5_MOUSE
AccessioniPrimary (citable) accession number: G3X9F5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 30, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.