ID   G3X981_MOUSE            Unreviewed;       507 AA.
AC   G3X981;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   SubName: Full=Peripherin {ECO:0000313|Ensembl:ENSMUSP00000049303.8};
GN   Name=Prph {ECO:0000313|Ensembl:ENSMUSP00000049303.8,
GN   ECO:0000313|MGI:MGI:97774};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000049303.8, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000049303.8, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000049303.8,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000049303.8}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000049303.8};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the intermediate filament family.
CC       {ECO:0000256|RuleBase:RU000685}.
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DR   RefSeq; NP_038667.2; NM_013639.2.
DR   RefSeq; XP_006520694.1; XM_006520631.3.
DR   AlphaFoldDB; G3X981; -.
DR   SMR; G3X981; -.
DR   jPOST; G3X981; -.
DR   MaxQB; G3X981; -.
DR   PeptideAtlas; G3X981; -.
DR   ProteomicsDB; 343104; -.
DR   Antibodypedia; 3724; 597 antibodies from 39 providers.
DR   DNASU; 19132; -.
DR   Ensembl; ENSMUST00000047104.15; ENSMUSP00000049303.8; ENSMUSG00000023484.15.
DR   GeneID; 19132; -.
DR   UCSC; uc007xon.2; mouse.
DR   AGR; MGI:97774; -.
DR   CTD; 5630; -.
DR   MGI; MGI:97774; Prph.
DR   VEuPathDB; HostDB:ENSMUSG00000023484; -.
DR   GeneTree; ENSGT00940000160203; -.
DR   HOGENOM; CLU_012560_7_4_1; -.
DR   OMA; THSRKMV; -.
DR   OrthoDB; 4640531at2759; -.
DR   PhylomeDB; G3X981; -.
DR   TreeFam; TF330122; -.
DR   BioGRID-ORCS; 19132; 1 hit in 77 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 15.
DR   Bgee; ENSMUSG00000023484; Expressed in trigeminal ganglion and 104 other cell types or tissues.
DR   ExpressionAtlas; G3X981; baseline and differential.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0007010; P:cytoskeleton organization; IEA:UniProt.
DR   Gene3D; 1.20.5.170; -; 1.
DR   Gene3D; 1.20.5.500; Single helix bin; 1.
DR   Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR   InterPro; IPR018039; IF_conserved.
DR   InterPro; IPR039008; IF_rod_dom.
DR   InterPro; IPR006821; Intermed_filament_DNA-bd.
DR   PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR   PANTHER; PTHR45652:SF14; PERIPHERIN; 1.
DR   Pfam; PF00038; Filament; 2.
DR   Pfam; PF04732; Filament_head; 1.
DR   SMART; SM01391; Filament; 1.
DR   SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR   PROSITE; PS00226; IF_ROD_1; 1.
DR   PROSITE; PS51842; IF_ROD_2; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW   ECO:0000256|RuleBase:RU000685};
KW   Proteomics identification {ECO:0007829|MaxQB:G3X981,
KW   ECO:0007829|PeptideAtlas:G3X981};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT   DOMAIN          101..443
FT                   /note="IF rod"
FT                   /evidence="ECO:0000259|PROSITE:PS51842"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          91..253
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          330..421
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        1..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   507 AA;  57864 MW;  8E26609474CD6D06 CRC64;
     MPSSASMSHH HSSGLRSSIS STSYRRTFGP PPSLSPGAFS YSSSSRFSSS RLLGSGSPSS
     SARLGSFRAP RAGALRLPSE RLDFSMAEAL NQEFLATRSN EKQELQELND RFANFIEKVR
     FLEQQNAALR GELSQARGQE PARADQLCQQ ELRELRRELE LLGRERDRVQ VERDGLAEDL
     AALKQRLEEE TRKREDAEHN LVLFRKDVDD ATLSRLELER KIESLMDEIE FLKKLHEEEL
     RDLQVSVESQ QVQQVEVEAT VKPELTAALR DIRAQYENIA AKNLQEAEEW YKSKVREHWG
     NPGGPRVGRH WEWRCASQPG LSATAQYADL SDAANRNHEA LRQAKQEMNE SRRQIQSLMC
     EVDGLRGTNE ALLRQLRELE EQFALEAGGY QAGAARLEEE LRQLKEEMAR HLREYQELLN
     VKMALDIEIA TYRKLLEGEE SRISVPVHSF ASLSLKTTVP EMEPLQDSHS KKMVLIRTIE
     TRDGEKVVTE SQKEQHSDLD KSSIHSY
//