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G3X8Z7

- G3X8Z7_MOUSE

UniProt

G3X8Z7 - G3X8Z7_MOUSE

Protein
Submitted name:

MCG5735

Gene

Chrna9

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. acetylcholine-activated cation-selective channel activity Source: MGI
    2. protein binding Source: MGI

    GO - Biological processi

    1. cation transport Source: MGI
    2. detection of mechanical stimulus involved in sensory perception of sound Source: MGI
    3. inner ear morphogenesis Source: MGI
    4. positive regulation of cytosolic calcium ion concentration Source: Ensembl

    Keywords - Molecular functioni

    Ion channel, Ligand-gated ion channelSAAS annotation, ReceptorSAAS annotation

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_198583. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MCG5735Imported
    Submitted name:
    Protein Chrna9Imported
    Gene namesi
    Name:Chrna9Imported
    ORF Names:mCG_5735Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:1202403. Chrna9.

    Subcellular locationi

    GO - Cellular componenti

    1. acetylcholine-gated channel complex Source: Ensembl
    2. cell junction Source: UniProtKB-KW
    3. postsynaptic membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell junction, Cell membraneSAAS annotation, Membrane, Postsynaptic cell membraneSAAS annotation, Synapse

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ligand-gated ion channel (TC 1.A.9) family. [View classification]UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115103.
    KOiK04810.
    OMAiDYCARYK.
    TreeFamiTF315605.

    Family and domain databases

    Gene3Di1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProiIPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view]
    PANTHERiPTHR18945. PTHR18945. 1 hit.
    PfamiPF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view]
    PRINTSiPR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMiSSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsiTIGR00860. LIC. 1 hit.
    PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3X8Z7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNRPHPCISF CWMYFAASGI KAVETANGKY AQKLFSDLFE DYSNALRPVE    50
    DTDAVLNVTL QVTLSQIKDM DERNQILTAY LWIRQTWHDA YLTWDRDQYD 100
    GLDSIRIPSD LVWRPDIVLY NKADDESSEP VNTNVVLRYD GLITWDSPAI 150
    TKSSCVVDVT YFPFDSQQCN LTFGSWTYNG NQVDIFNALD SGDLSDFIED 200
    VEWEVQGMPA VKNVISYGCC SEPYPDVTFT LLLKRRSSFY IVNLLIPCVL 250
    ISFLAPLSFY LPAASGEKVS LGVTILLAMT VFQLMVAEIM PASENVPLIG 300
    KYYIATMALI TASTALTIMV MNIHFCGAEA RPVPHWAKVV ILKYMSRILF 350
    VYDVGESCLS PRHSQEPEQI TKVYGKLPGS NLKASRNKDL SRKKELRKLL 400
    KNDLGYQGGI PQNTDSYCAR YEALTKNIEY IAKCLKDHKA TNSKGSEWKK 450
    VAKVIDRFFM WIFFAMVFVM TVLIIARAD 479
    Length:479
    Mass (Da):54,323
    Last modified:November 16, 2011 - v1
    Checksum:i2F639CEF6A456BCE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115293 Genomic DNA. No translation available.
    CH466524 Genomic DNA. Translation: EDL37758.1.
    RefSeqiNP_001074573.1. NM_001081104.1.
    UniGeneiMm.486671.

    Genome annotation databases

    EnsembliENSMUST00000031108; ENSMUSP00000031108; ENSMUSG00000029205.
    GeneIDi231252.
    KEGGimmu:231252.
    UCSCiuc008xog.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC115293 Genomic DNA. No translation available.
    CH466524 Genomic DNA. Translation: EDL37758.1 .
    RefSeqi NP_001074573.1. NM_001081104.1.
    UniGenei Mm.486671.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031108 ; ENSMUSP00000031108 ; ENSMUSG00000029205 .
    GeneIDi 231252.
    KEGGi mmu:231252.
    UCSCi uc008xog.1. mouse.

    Organism-specific databases

    CTDi 55584.
    MGIi MGI:1202403. Chrna9.

    Phylogenomic databases

    GeneTreei ENSGT00740000115103.
    KOi K04810.
    OMAi DYCARYK.
    TreeFami TF315605.

    Enzyme and pathway databases

    Reactomei REACT_198583. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.

    Miscellaneous databases

    ChiTaRSi CHRNA9. mouse.
    NextBioi 380471.
    PROi G3X8Z7.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 1.20.120.370. 2 hits.
    2.70.170.10. 1 hit.
    InterProi IPR027361. Acetylcholine_rcpt_TM.
    IPR006202. Neur_chan_lig-bd.
    IPR006201. Neur_channel.
    IPR006029. Neurotrans-gated_channel_TM.
    IPR018000. Neurotransmitter_ion_chnl_CS.
    IPR002394. Nicotinic_acetylcholine_rcpt.
    [Graphical view ]
    PANTHERi PTHR18945. PTHR18945. 1 hit.
    Pfami PF02931. Neur_chan_LBD. 1 hit.
    PF02932. Neur_chan_memb. 1 hit.
    [Graphical view ]
    PRINTSi PR00254. NICOTINICR.
    PR00252. NRIONCHANNEL.
    SUPFAMi SSF63712. SSF63712. 1 hit.
    SSF90112. SSF90112. 1 hit.
    TIGRFAMsi TIGR00860. LIC. 1 hit.
    PROSITEi PS00236. NEUROTR_ION_CHANNEL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiG3X8Z7_MOUSE
    AccessioniPrimary (citable) accession number: G3X8Z7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3