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G3X8Y8

- G3X8Y8_MOUSE

UniProt

G3X8Y8 - G3X8Y8_MOUSE

Protein

Toll-like receptor

Gene

Tlr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. diacyl lipopeptide binding Source: MGI
    2. lipoteichoic acid binding Source: MGI
    3. peptidoglycan binding Source: Ensembl
    4. protein heterodimerization activity Source: MGI
    5. signaling pattern recognition receptor activity Source: Ensembl
    6. transmembrane signaling receptor activity Source: InterPro
    7. triacyl lipopeptide binding Source: MGI

    GO - Biological processi

    1. cell surface pattern recognition receptor signaling pathway Source: MGI
    2. cellular response to bacterial lipopeptide Source: MGI
    3. cellular response to diacyl bacterial lipopeptide Source: Ensembl
    4. cellular response to lipoteichoic acid Source: MGI
    5. cellular response to peptidoglycan Source: MGI
    6. cellular response to triacyl bacterial lipopeptide Source: Ensembl
    7. central nervous system myelin formation Source: Ensembl
    8. chloramphenicol transport Source: MGI
    9. defense response to Gram-positive bacterium Source: MGI
    10. detection of diacyl bacterial lipopeptide Source: Ensembl
    11. detection of triacyl bacterial lipopeptide Source: Ensembl
    12. I-kappaB phosphorylation Source: Ensembl
    13. induction by symbiont of defense-related host nitric oxide production Source: MGI
    14. inflammatory response Source: UniProtKB-KW
    15. innate immune response Source: UniProtKB-KW
    16. leukotriene metabolic process Source: Ensembl
    17. microglial cell activation involved in immune response Source: Ensembl
    18. MyD88-dependent toll-like receptor signaling pathway Source: MGI
    19. negative regulation of cell proliferation Source: Ensembl
    20. negative regulation of growth of symbiont in host Source: MGI
    21. negative regulation of interleukin-12 production Source: MGI
    22. negative regulation of interleukin-17 production Source: MGI
    23. nitric oxide metabolic process Source: Ensembl
    24. pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response Source: Ensembl
    25. positive regulation of chemokine production Source: MGI
    26. positive regulation of cytokine secretion Source: MGI
    27. positive regulation of inflammatory response Source: InterPro
    28. positive regulation of interleukin-10 production Source: Ensembl
    29. positive regulation of interleukin-6 production Source: MGI
    30. positive regulation of interleukin-8 production Source: Ensembl
    31. positive regulation of leukocyte migration Source: MGI
    32. positive regulation of macrophage cytokine production Source: MGI
    33. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    34. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
    35. positive regulation of nitric oxide biosynthetic process Source: MGI
    36. positive regulation of oligodendrocyte differentiation Source: Ensembl
    37. positive regulation of toll-like receptor signaling pathway Source: Ensembl
    38. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
    39. positive regulation of tumor necrosis factor production Source: MGI
    40. positive regulation of Wnt signaling pathway Source: Ensembl
    41. response to bacterium Source: MGI
    42. response to fatty acid Source: Ensembl
    43. response to hypoxia Source: Ensembl
    44. response to insulin Source: Ensembl
    45. response to lipopolysaccharide Source: Ensembl
    46. response to molecule of fungal origin Source: MGI
    47. response to peptidoglycan Source: MGI
    48. response to progesterone Source: Ensembl
    49. response to toxic substance Source: Ensembl
    50. toll-like receptor 2 signaling pathway Source: InterPro

    Keywords - Molecular functioni

    ReceptorUniRule annotationImported

    Keywords - Biological processi

    Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptorUniRule annotation
    Gene namesi
    Name:Tlr2Imported
    ORF Names:mCG_17071Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1346060. Tlr2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell body Source: Ensembl
    2. cell projection Source: Ensembl
    3. cytoplasm Source: Ensembl
    4. external side of plasma membrane Source: MGI
    5. integral component of membrane Source: UniProtKB-KW
    6. plasma membrane Source: MGI
    7. Toll-like receptor 1-Toll-like receptor 2 protein complex Source: MGI
    8. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: MGI

    Keywords - Cellular componenti

    Membrane

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.UniRule annotation
    Contains TIR domain.SAAS annotation

    Keywords - Domaini

    Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00700000104367.
    KOiK10159.
    OMAiLGNPYKT.
    OrthoDBiEOG7SBNN7.
    TreeFamiTF351113.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027185. TLR2.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
    PfamiPF13504. LRR_7. 2 hits.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 9 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3X8Y8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL    50
    TAAMKSLDLS FNKITYIGHG DLRACANLQV LMLKSSRINT IEGDAFYSLG 100
    SLEHLDLSDN HLSSLSSSWF GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN 150
    LQTLRIGNVE TFSEIRRIDF AGLTSLNELE IKALSLRNYQ SQSLKSIRDI 200
    HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS PLPVDEVSSP 250
    MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES 300
    DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL 350
    VPCSFSQHLK SLEFLDLSEN LMVEEYLKNS ACKGAWPSLQ TLVLSQNHLR 400
    SMQKTGEILL TLKNLTSLDI SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV 450
    VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ ELYISRNKLK TLPDASLFPV 500
    LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE LLSFTMETPA 550
    LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL 600
    LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ 650
    DSHWVENLMV QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV 700
    FVLSENFVRS EWCKYELDFS HFRLFDENND AAILVLLEPI ERKAIPQRFC 750
    KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT AIKS 784
    Length:784
    Mass (Da):89,467
    Last modified:November 16, 2011 - v1
    Checksum:iBCBE96FCB988D858
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC133160 Genomic DNA. No translation available.
    CH466547 Genomic DNA. Translation: EDL15415.1.
    RefSeqiNP_036035.3. NM_011905.3.
    UniGeneiMm.87596.

    Genome annotation databases

    EnsembliENSMUST00000029623; ENSMUSP00000029623; ENSMUSG00000027995.
    GeneIDi24088.
    KEGGimmu:24088.
    UCSCiuc008ppn.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC133160 Genomic DNA. No translation available.
    CH466547 Genomic DNA. Translation: EDL15415.1 .
    RefSeqi NP_036035.3. NM_011905.3.
    UniGenei Mm.87596.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029623 ; ENSMUSP00000029623 ; ENSMUSG00000027995 .
    GeneIDi 24088.
    KEGGi mmu:24088.
    UCSCi uc008ppn.2. mouse.

    Organism-specific databases

    CTDi 7097.
    MGIi MGI:1346060. Tlr2.

    Phylogenomic databases

    GeneTreei ENSGT00700000104367.
    KOi K10159.
    OMAi LGNPYKT.
    OrthoDBi EOG7SBNN7.
    TreeFami TF351113.

    Miscellaneous databases

    NextBioi 304101.
    SOURCEi Search...

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000157. TIR_dom.
    IPR027185. TLR2.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF17. PTHR24365:SF17. 1 hit.
    Pfami PF13504. LRR_7. 2 hits.
    PF13855. LRR_8. 1 hit.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 9 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiG3X8Y8_MOUSE
    AccessioniPrimary (citable) accession number: G3X8Y8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3