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G3X8Y8

- G3X8Y8_MOUSE

UniProt

G3X8Y8 - G3X8Y8_MOUSE

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Protein

Toll-like receptor

Gene

Tlr2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. diacyl lipopeptide binding Source: MGI
  2. lipoteichoic acid binding Source: MGI
  3. peptidoglycan binding Source: Ensembl
  4. protein heterodimerization activity Source: MGI
  5. signaling pattern recognition receptor activity Source: Ensembl
  6. transmembrane signaling receptor activity Source: InterPro
  7. triacyl lipopeptide binding Source: MGI

GO - Biological processi

  1. cell surface pattern recognition receptor signaling pathway Source: MGI
  2. cellular response to bacterial lipopeptide Source: MGI
  3. cellular response to diacyl bacterial lipopeptide Source: Ensembl
  4. cellular response to lipoteichoic acid Source: MGI
  5. cellular response to peptidoglycan Source: MGI
  6. cellular response to triacyl bacterial lipopeptide Source: Ensembl
  7. central nervous system myelin formation Source: Ensembl
  8. chloramphenicol transport Source: MGI
  9. defense response to Gram-positive bacterium Source: MGI
  10. detection of diacyl bacterial lipopeptide Source: Ensembl
  11. detection of triacyl bacterial lipopeptide Source: Ensembl
  12. I-kappaB phosphorylation Source: Ensembl
  13. induction by symbiont of defense-related host nitric oxide production Source: MGI
  14. inflammatory response Source: UniProtKB-KW
  15. innate immune response Source: UniProtKB-KW
  16. leukotriene metabolic process Source: Ensembl
  17. microglial cell activation Source: Ensembl
  18. MyD88-dependent toll-like receptor signaling pathway Source: MGI
  19. negative regulation of cell proliferation Source: Ensembl
  20. negative regulation of growth of symbiont in host Source: MGI
  21. negative regulation of interleukin-12 production Source: MGI
  22. negative regulation of interleukin-17 production Source: MGI
  23. nitric oxide metabolic process Source: Ensembl
  24. positive regulation of chemokine production Source: MGI
  25. positive regulation of cytokine secretion Source: MGI
  26. positive regulation of inflammatory response Source: InterPro
  27. positive regulation of interleukin-10 production Source: Ensembl
  28. positive regulation of interleukin-6 production Source: MGI
  29. positive regulation of interleukin-8 production Source: Ensembl
  30. positive regulation of leukocyte migration Source: MGI
  31. positive regulation of macrophage cytokine production Source: MGI
  32. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  33. positive regulation of NF-kappaB transcription factor activity Source: Ensembl
  34. positive regulation of nitric oxide biosynthetic process Source: MGI
  35. positive regulation of oligodendrocyte differentiation Source: Ensembl
  36. positive regulation of toll-like receptor signaling pathway Source: Ensembl
  37. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
  38. positive regulation of tumor necrosis factor production Source: MGI
  39. positive regulation of Wnt signaling pathway Source: Ensembl
  40. response to bacterium Source: MGI
  41. response to fatty acid Source: Ensembl
  42. response to hypoxia Source: Ensembl
  43. response to insulin Source: Ensembl
  44. response to lipopolysaccharide Source: Ensembl
  45. response to molecule of fungal origin Source: MGI
  46. response to peptidoglycan Source: MGI
  47. response to progesterone Source: Ensembl
  48. response to toxic substance Source: Ensembl
  49. toll-like receptor 2 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotationImported

Keywords - Biological processi

Immunity, Inflammatory responseUniRule annotation, Innate immunityUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_230045. MyD88:Mal cascade initiated on plasma membrane.
REACT_254406. Toll Like Receptor TLR6:TLR2 Cascade.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptorUniRule annotation
Gene namesi
Name:Tlr2Imported
ORF Names:mCG_17071Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1346060. Tlr2.

Subcellular locationi

GO - Cellular componenti

  1. cell body Source: Ensembl
  2. cell projection Source: Ensembl
  3. cytoplasm Source: Ensembl
  4. external side of plasma membrane Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: MGI
  7. Toll-like receptor 1-Toll-like receptor 2 protein complex Source: MGI
  8. Toll-like receptor 2-Toll-like receptor 6 protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Family & Domainsi

Sequence similaritiesi

Belongs to the Toll-like receptor family.UniRule annotation
Contains TIR domain.SAAS annotation

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000119006.
KOiK10159.
OMAiLGNPYKT.
OrthoDBiEOG7SBNN7.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamiPF13504. LRR_7. 2 hits.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3X8Y8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL
60 70 80 90 100
TAAMKSLDLS FNKITYIGHG DLRACANLQV LMLKSSRINT IEGDAFYSLG
110 120 130 140 150
SLEHLDLSDN HLSSLSSSWF GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN
160 170 180 190 200
LQTLRIGNVE TFSEIRRIDF AGLTSLNELE IKALSLRNYQ SQSLKSIRDI
210 220 230 240 250
HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS PLPVDEVSSP
260 270 280 290 300
MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES
310 320 330 340 350
DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL
360 370 380 390 400
VPCSFSQHLK SLEFLDLSEN LMVEEYLKNS ACKGAWPSLQ TLVLSQNHLR
410 420 430 440 450
SMQKTGEILL TLKNLTSLDI SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV
460 470 480 490 500
VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ ELYISRNKLK TLPDASLFPV
510 520 530 540 550
LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE LLSFTMETPA
560 570 580 590 600
LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL
610 620 630 640 650
LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ
660 670 680 690 700
DSHWVENLMV QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV
710 720 730 740 750
FVLSENFVRS EWCKYELDFS HFRLFDENND AAILVLLEPI ERKAIPQRFC
760 770 780
KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT AIKS
Length:784
Mass (Da):89,467
Last modified:November 16, 2011 - v1
Checksum:iBCBE96FCB988D858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133160 Genomic DNA. No translation available.
CH466547 Genomic DNA. Translation: EDL15415.1.
RefSeqiNP_036035.3. NM_011905.3.
UniGeneiMm.87596.

Genome annotation databases

EnsembliENSMUST00000029623; ENSMUSP00000029623; ENSMUSG00000027995.
GeneIDi24088.
KEGGimmu:24088.
UCSCiuc008ppn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC133160 Genomic DNA. No translation available.
CH466547 Genomic DNA. Translation: EDL15415.1 .
RefSeqi NP_036035.3. NM_011905.3.
UniGenei Mm.87596.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029623 ; ENSMUSP00000029623 ; ENSMUSG00000027995 .
GeneIDi 24088.
KEGGi mmu:24088.
UCSCi uc008ppn.2. mouse.

Organism-specific databases

CTDi 7097.
MGIi MGI:1346060. Tlr2.

Phylogenomic databases

GeneTreei ENSGT00760000119006.
KOi K10159.
OMAi LGNPYKT.
OrthoDBi EOG7SBNN7.
TreeFami TF351113.

Enzyme and pathway databases

Reactomei REACT_230045. MyD88:Mal cascade initiated on plasma membrane.
REACT_254406. Toll Like Receptor TLR6:TLR2 Cascade.

Miscellaneous databases

NextBioi 304101.
SOURCEi Search...

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view ]
PANTHERi PTHR24365:SF17. PTHR24365:SF17. 1 hit.
Pfami PF13504. LRR_7. 2 hits.
PF13855. LRR_8. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG3X8Y8_MOUSE
AccessioniPrimary (citable) accession number: G3X8Y8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 26, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3