G3X8Y8 (G3X8Y8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Toll-like receptor PIRNR PIRNR037595

Gene names

Name:	Tlr2 EMBL EDL15415.1 MGI 1346060 Ensembl ENSMUSP00000029623
ORF Names:	mCG_17071 EMBL EDL15415.1

Organism

Mus musculus (Mouse) [Reference proteome] Ensembl ENSMUSP00000029623

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	784 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the Toll-like receptor family. PIRNR PIRNR037595 Contains 1 TIR domain. SAAS SAAS000483

Ontologies

Keywords
Biological process	Immunity Inflammatory response PIRNR PIRNR037595 Innate immunity PIRNR PIRNR037595
Cellular component	Membrane
Domain	Leucine-rich repeat SAAS SAAS000483 Repeat SAAS SAAS000483 Transmembrane Transmembrane helix SAAS SAAS000483
Molecular function	Receptor PIRNR PIRNR037595 EMBL EDL15415.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	I-kappaB phosphorylation Inferred from electronic annotation. Source: Compara MyD88-dependent toll-like receptor signaling pathway Inferred from genetic interaction PubMed 12719478. Source: MGI cell surface pattern recognition receptor signaling pathway Inferred from mutant phenotype PubMed 12719478. Source: MGI cellular response to bacterial lipopeptide Inferred from mutant phenotype PubMed 15690042. Source: MGI cellular response to diacyl bacterial lipopeptide Inferred from electronic annotation. Source: Compara cellular response to lipoteichoic acid Inferred from mutant phenotype PubMed 15690042. Source: MGI cellular response to peptidoglycan Inferred from mutant phenotype PubMed 16949315. Source: MGI cellular response to triacyl bacterial lipopeptide Inferred from electronic annotation. Source: Compara chloramphenicol transport Inferred from mutant phenotype PubMed 12091878. Source: MGI defense response to Gram-positive bacterium Inferred from mutant phenotype PubMed 11067888PubMed 15690042PubMed 19139201. Source: MGI detection of diacyl bacterial lipopeptide Inferred from electronic annotation. Source: Compara detection of triacyl bacterial lipopeptide Inferred from electronic annotation. Source: Compara induction by symbiont of defense-related host nitric oxide production Inferred from mutant phenotype PubMed 16239543. Source: MGI inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW innate immune response Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of growth of symbiont in host Inferred from mutant phenotype PubMed 11067888PubMed 15690042. Source: MGI negative regulation of interleukin-12 production Inferred from mutant phenotype PubMed 16949315. Source: MGI negative regulation of interleukin-17 production Inferred from mutant phenotype PubMed 16239543. Source: MGI positive regulation of NF-kappaB import into nucleus Inferred from electronic annotation. Source: Compara positive regulation of NF-kappaB transcription factor activity Inferred from electronic annotation. Source: Compara positive regulation of Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of chemokine production Inferred from mutant phenotype PubMed 16239543. Source: MGI positive regulation of cytokine secretion Inferred from genetic interaction PubMed 19770268. Source: MGI positive regulation of inflammatory response Inferred from electronic annotation. Source: InterPro positive regulation of interleukin-6 production Inferred from direct assay PubMed 18261938. Source: MGI positive regulation of interleukin-8 production Inferred from electronic annotation. Source: Compara positive regulation of leukocyte migration Inferred from mutant phenotype PubMed 17114491. Source: MGI positive regulation of macrophage cytokine production Inferred from mutant phenotype PubMed 10549626. Source: MGI positive regulation of nitric oxide biosynthetic process Inferred from mutant phenotype PubMed 10549626PubMed 16239543. Source: MGI positive regulation of toll-like receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of tumor necrosis factor biosynthetic process Inferred from mutant phenotype PubMed 16239543. Source: MGI positive regulation of tumor necrosis factor production Inferred from mutant phenotype PubMed 10549626PubMed 11067888PubMed 12719478PubMed 15690042PubMed 16239543. Source: MGI response to molecule of fungal origin Inferred from mutant phenotype PubMed 12719478. Source: MGI toll-like receptor 2 signaling pathway Inferred from electronic annotation. Source: InterPro
Cellular_component	Toll-like receptor 1-Toll-like receptor 2 protein complex Inferred from sequence orthology PubMed 17889651. Source: MGI Toll-like receptor 2-Toll-like receptor 6 protein complex Inferred from physical interaction PubMed 19931471. Source: MGI cytoplasm Inferred from electronic annotation. Source: Compara external side of plasma membrane Inferred from direct assay PubMed 15220916. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	Gram-positive bacterial cell surface binding Inferred from electronic annotation. Source: Compara diacyl lipopeptide binding Inferred from direct assay PubMed 17889651PubMed 19931471. Source: MGI lipoteichoic acid binding Inferred from direct assay PubMed 19931471. Source: MGI pattern recognition receptor activity Inferred from electronic annotation. Source: Compara peptidoglycan binding Inferred from electronic annotation. Source: Compara protein heterodimerization activity Inferred from sequence orthology PubMed 17889651. Source: MGI transmembrane signaling receptor activity Inferred from electronic annotation. Source: InterPro triacyl lipopeptide binding Inferred from direct assay PubMed 17889651. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G3X8Y8 [UniParc]. Last modified November 16, 2011. Version 1. Checksum: BCBE96FCB988D858	FASTA	784	89,467
	10 20 30 40 50 60 MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL TAAMKSLDLS 70 80 90 100 110 120 FNKITYIGHG DLRACANLQV LMLKSSRINT IEGDAFYSLG SLEHLDLSDN HLSSLSSSWF 130 140 150 160 170 180 GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN LQTLRIGNVE TFSEIRRIDF AGLTSLNELE 190 200 210 220 230 240 IKALSLRNYQ SQSLKSIRDI HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS 250 260 270 280 290 300 PLPVDEVSSP MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES 310 320 330 340 350 360 DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL VPCSFSQHLK 370 380 390 400 410 420 SLEFLDLSEN LMVEEYLKNS ACKGAWPSLQ TLVLSQNHLR SMQKTGEILL TLKNLTSLDI 430 440 450 460 470 480 SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ 490 500 510 520 530 540 ELYISRNKLK TLPDASLFPV LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE 550 560 570 580 590 600 LLSFTMETPA LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL 610 620 630 640 650 660 LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ DSHWVENLMV 670 680 690 700 710 720 QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV FVLSENFVRS EWCKYELDFS 730 740 750 760 770 780 HFRLFDENND AAILVLLEPI ERKAIPQRFC KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT AIKS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome." Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D. Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL15415.1.
[2]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: Mixed EMBL EDL15415.1.
[3]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000029623.
[4]	Ensembl Submitted (SEP-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000029623.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC133160 Genomic DNA. No translation available. CH466547 Genomic DNA. Translation: EDL15415.1.
RefSeq	NP_036035.3. NM_011905.3.
UniGene	Mm.87596.
3D structure databases
SMR	G3X8Y8. Positions 27-784.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029623; ENSMUSP00000029623; ENSMUSG00000027995.
GeneID	24088.
KEGG	mmu:24088.
Organism-specific databases
CTD	7097.
MGI	MGI:1346060. Tlr2.
Phylogenomic databases
GeneTree	ENSGT00700000104367.
KO	K10159.
OMA	IDWPENY.
Family and domain databases
InterPro	IPR000483. Cys-rich_flank_reg_C. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000157. TIR_dom. IPR027185. TLR2. IPR017241. Toll-like_receptor. [Graphical view]
PANTHER	PTHR24365:SF17. PTHR24365:SF17. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
PIRSF	PIRSF037595. Toll-like_receptor. 1 hit.
SMART	SM00369. LRR_TYP. 2 hits. SM00082. LRRCT. 1 hit. SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS51450. LRR. 9 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	304101.
SOURCE	Search...

Entry information

Entry name

G3X8Y8_MOUSE

Accession

Primary (citable) accession number: G3X8Y8

Entry history

Integrated into UniProtKB/TrEMBL:	November 16, 2011
Last sequence update:	November 16, 2011
Last modified:	May 1, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)