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G3X8Y8 (G3X8Y8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein attributes

Sequence length784 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Sequence similarities

Belongs to the Toll-like receptor family. PIRNR PIRNR037595

Contains TIR domain. SAAS SAAS000157

Ontologies

Keywords
   Biological processImmunity
Inflammatory response PIRNR PIRNR037595
Innate immunity PIRNR PIRNR037595
   Cellular componentMembrane
   DomainLeucine-rich repeat SAAS SAAS000157
Repeat SAAS SAAS000157
Transmembrane
Transmembrane helix SAAS SAAS000157
   Molecular functionReceptor PIRNR PIRNR037595 EMBL EDL15415.1
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processI-kappaB phosphorylation

Inferred from electronic annotation. Source: Ensembl

MyD88-dependent toll-like receptor signaling pathway

Inferred from genetic interaction PubMed 12719478. Source: MGI

cell surface pattern recognition receptor signaling pathway

Inferred from mutant phenotype PubMed 12719478. Source: MGI

cellular response to bacterial lipopeptide

Inferred from mutant phenotype PubMed 15690042. Source: MGI

cellular response to diacyl bacterial lipopeptide

Inferred from electronic annotation. Source: Ensembl

cellular response to lipoteichoic acid

Inferred from mutant phenotype PubMed 15690042. Source: MGI

cellular response to peptidoglycan

Inferred from mutant phenotype PubMed 16949315. Source: MGI

cellular response to triacyl bacterial lipopeptide

Inferred from electronic annotation. Source: Ensembl

central nervous system myelin formation

Inferred from electronic annotation. Source: Ensembl

chloramphenicol transport

Inferred from mutant phenotype PubMed 12091878. Source: MGI

defense response to Gram-positive bacterium

Inferred from mutant phenotype PubMed 11067888PubMed 15690042PubMed 19139201. Source: MGI

detection of diacyl bacterial lipopeptide

Inferred from electronic annotation. Source: Ensembl

detection of triacyl bacterial lipopeptide

Inferred from electronic annotation. Source: Ensembl

induction by symbiont of defense-related host nitric oxide production

Inferred from mutant phenotype PubMed 16239543. Source: MGI

inflammatory response

Inferred from electronic annotation. Source: UniProtKB-KW

innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

leukotriene metabolic process

Inferred from electronic annotation. Source: Ensembl

microglial cell activation involved in immune response

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of growth of symbiont in host

Inferred from mutant phenotype PubMed 11067888PubMed 15690042. Source: MGI

negative regulation of interleukin-12 production

Inferred from mutant phenotype PubMed 16949315. Source: MGI

negative regulation of interleukin-17 production

Inferred from mutant phenotype PubMed 16239543. Source: MGI

nitric oxide metabolic process

Inferred from electronic annotation. Source: Ensembl

pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response

Inferred from electronic annotation. Source: Ensembl

positive regulation of NF-kappaB import into nucleus

Inferred from electronic annotation. Source: Ensembl

positive regulation of NF-kappaB transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of Wnt signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine production

Inferred from mutant phenotype PubMed 16239543. Source: MGI

positive regulation of cytokine secretion

Inferred from genetic interaction PubMed 19770268. Source: MGI

positive regulation of inflammatory response

Inferred from electronic annotation. Source: InterPro

positive regulation of interleukin-10 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interleukin-6 production

Inferred from direct assay PubMed 18261938. Source: MGI

positive regulation of interleukin-8 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte migration

Inferred from mutant phenotype PubMed 17114491. Source: MGI

positive regulation of macrophage cytokine production

Inferred from mutant phenotype PubMed 10549626. Source: MGI

positive regulation of nitric oxide biosynthetic process

Inferred from mutant phenotype PubMed 10549626PubMed 16239543. Source: MGI

positive regulation of oligodendrocyte differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of toll-like receptor signaling pathway

Inferred from electronic annotation. Source: Ensembl

positive regulation of tumor necrosis factor biosynthetic process

Inferred from mutant phenotype PubMed 16239543. Source: MGI

positive regulation of tumor necrosis factor production

Inferred from mutant phenotype PubMed 10549626PubMed 11067888PubMed 12719478PubMed 15690042PubMed 16239543. Source: MGI

response to bacterium

Inferred from mutant phenotype PubMed 17114491. Source: MGI

response to fatty acid

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to insulin

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

response to molecule of fungal origin

Inferred from mutant phenotype PubMed 12719478. Source: MGI

response to peptidoglycan

Inferred from mutant phenotype PubMed 10549626PubMed 17114491. Source: MGI

response to progesterone

Inferred from electronic annotation. Source: Ensembl

response to toxic substance

Inferred from electronic annotation. Source: Ensembl

toll-like receptor 2 signaling pathway

Inferred from electronic annotation. Source: InterPro

   Cellular_componentToll-like receptor 1-Toll-like receptor 2 protein complex

Inferred from sequence orthology PubMed 17889651. Source: MGI

Toll-like receptor 2-Toll-like receptor 6 protein complex

Inferred from physical interaction PubMed 19931471. Source: MGI

cell body

Inferred from electronic annotation. Source: Ensembl

cell projection

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from electronic annotation. Source: Ensembl

external side of plasma membrane

Inferred from direct assay PubMed 15220916. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay PubMed 12719478. Source: MGI

   Molecular_functiondiacyl lipopeptide binding

Inferred from direct assay PubMed 17889651PubMed 19931471. Source: MGI

lipoteichoic acid binding

Inferred from direct assay PubMed 19931471. Source: MGI

peptidoglycan binding

Inferred from electronic annotation. Source: Ensembl

protein heterodimerization activity

Inferred from physical interaction PubMed 19931471. Source: MGI

signaling pattern recognition receptor activity

Inferred from electronic annotation. Source: Ensembl

transmembrane signaling receptor activity

Inferred from electronic annotation. Source: InterPro

triacyl lipopeptide binding

Inferred from direct assay PubMed 17889651. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
G3X8Y8 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: BCBE96FCB988D858

FASTA78489,467
        10         20         30         40         50         60 
MLRALWLFWI LVAITVLFSK RCSAQESLSC DASGVCDGRS RSFTSIPSGL TAAMKSLDLS 

        70         80         90        100        110        120 
FNKITYIGHG DLRACANLQV LMLKSSRINT IEGDAFYSLG SLEHLDLSDN HLSSLSSSWF 

       130        140        150        160        170        180 
GPLSSLKYLN LMGNPYQTLG VTSLFPNLTN LQTLRIGNVE TFSEIRRIDF AGLTSLNELE 

       190        200        210        220        230        240 
IKALSLRNYQ SQSLKSIRDI HHLTLHLSES AFLLEIFADI LSSVRYLELR DTNLARFQFS 

       250        260        270        280        290        300 
PLPVDEVSSP MKKLAFRGSV LTDESFNELL KLLRYILELS EVEFDDCTLN GLGDFNPSES 

       310        320        330        340        350        360 
DVVSELGKVE TVTIRRLHIP QFYLFYDLST VYSLLEKVKR ITVENSKVFL VPCSFSQHLK 

       370        380        390        400        410        420 
SLEFLDLSEN LMVEEYLKNS ACKGAWPSLQ TLVLSQNHLR SMQKTGEILL TLKNLTSLDI 

       430        440        450        460        470        480 
SRNTFHPMPD SCQWPEKMRF LNLSSTGIRV VKTCIPQTLE VLDVSNNNLD SFSLFLPRLQ 

       490        500        510        520        530        540 
ELYISRNKLK TLPDASLFPV LLVMKIRENA VSTFSKDQLG SFPKLETLEA GDNHFVCSCE 

       550        560        570        580        590        600 
LLSFTMETPA LAQILVDWPD SYLCDSPPRL HGHRLQDARP SVLECHQAAL VSGVCCALLL 

       610        620        630        640        650        660 
LILLVGALCH HFHGLWYLRM MWAWLQAKRK PKKAPCRDVC YDAFVSYSEQ DSHWVENLMV 

       670        680        690        700        710        720 
QQLENSDPPF KLCLHKRDFV PGKWIIDNII DSIEKSHKTV FVLSENFVRS EWCKYELDFS 

       730        740        750        760        770        780 
HFRLFDENND AAILVLLEPI ERKAIPQRFC KLRKIMNTKT YLEWPLDEGQ QEVFWVNLRT 


AIKS 

« Hide

References

« Hide 'large scale' references
[1]"A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W. expand/collapse author list , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL15415.1.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: Mixed EMBL EDL15415.1.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000029623.
[4]Ensembl
Submitted (SEP-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000029623.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC133160 Genomic DNA. No translation available.
CH466547 Genomic DNA. Translation: EDL15415.1.
RefSeqNP_036035.3. NM_011905.3.
UniGeneMm.87596.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029623; ENSMUSP00000029623; ENSMUSG00000027995.
GeneID24088.
KEGGmmu:24088.
UCSCuc008ppn.2. mouse.

Organism-specific databases

CTD7097.
MGIMGI:1346060. Tlr2.

Phylogenomic databases

GeneTreeENSGT00700000104367.
KOK10159.
OMARDVCYDA.
OrthoDBEOG7SBNN7.
TreeFamTF351113.

Family and domain databases

Gene3D3.40.50.10140. 1 hit.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027185. TLR2.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERPTHR24365:SF17. PTHR24365:SF17. 1 hit.
PfamPF01582. TIR. 1 hit.
[Graphical view]
PIRSFPIRSF037595. Toll-like_receptor. 1 hit.
SMARTSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMSSF52200. SSF52200. 1 hit.
PROSITEPS51450. LRR. 9 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio304101.
SOURCESearch...

Entry information

Entry nameG3X8Y8_MOUSE
AccessionPrimary (citable) accession number: G3X8Y8
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 16, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)