ID   G3X8W6_MOUSE            Unreviewed;       466 AA.
AC   G3X8W6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 86.
DE   SubName: Full=Regulator of G-protein signaling 11 {ECO:0000313|Ensembl:ENSMUSP00000025020.6};
GN   Name=Rgs11 {ECO:0000313|Ensembl:ENSMUSP00000025020.6,
GN   ECO:0000313|MGI:MGI:1354739};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000025020.6, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000025020.6, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025020.6,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000025020.6}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000025020.6};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; NP_001074538.1; NM_001081069.1.
DR   AlphaFoldDB; G3X8W6; -.
DR   SMR; G3X8W6; -.
DR   Antibodypedia; 22598; 155 antibodies from 27 providers.
DR   DNASU; 50782; -.
DR   Ensembl; ENSMUST00000025020.6; ENSMUSP00000025020.6; ENSMUSG00000024186.16.
DR   GeneID; 50782; -.
DR   KEGG; mmu:50782; -.
DR   UCSC; uc008bdr.1; mouse.
DR   AGR; MGI:1354739; -.
DR   CTD; 8786; -.
DR   MGI; MGI:1354739; Rgs11.
DR   VEuPathDB; HostDB:ENSMUSG00000024186; -.
DR   GeneTree; ENSGT00940000160198; -.
DR   OMA; WAFNFRE; -.
DR   OrthoDB; 22856at2759; -.
DR   PhylomeDB; G3X8W6; -.
DR   TreeFam; TF351956; -.
DR   BioGRID-ORCS; 50782; 1 hit in 76 CRISPR screens.
DR   ChiTaRS; Rgs11; mouse.
DR   Proteomes; UP000000589; Chromosome 17.
DR   Bgee; ENSMUSG00000024186; Expressed in retinal neural layer and 167 other cell types or tissues.
DR   ExpressionAtlas; G3X8W6; baseline and differential.
DR   GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR   GO; GO:0031681; F:G-protein beta-subunit binding; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G protein-coupled receptor signaling pathway; IEA:InterPro.
DR   CDD; cd04450; DEP_RGS7-like; 1.
DR   CDD; cd00068; GGL; 1.
DR   Gene3D; 1.10.1240.60; -; 1.
DR   Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR   Gene3D; 4.10.260.10; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR015898; G-protein_gamma-like_dom.
DR   InterPro; IPR036284; GGL_sf.
DR   InterPro; IPR016137; RGS.
DR   InterPro; IPR047016; RGS6/7/9/11.
DR   InterPro; IPR047017; RGS6/7/9/11_DHEX_sf.
DR   InterPro; IPR040759; RGS_DHEX.
DR   InterPro; IPR036305; RGS_sf.
DR   InterPro; IPR044926; RGS_subdomain_2.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR45746; LP21163P; 1.
DR   PANTHER; PTHR45746:SF3; REGULATOR OF G-PROTEIN SIGNALING 11; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF00631; G-gamma; 1.
DR   Pfam; PF00615; RGS; 1.
DR   Pfam; PF18148; RGS_DHEX; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM01224; G_gamma; 1.
DR   SMART; SM00224; GGL; 1.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR   SUPFAM; SSF48670; Transducin (heterotrimeric G protein), gamma chain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50186; DEP; 1.
DR   PROSITE; PS50132; RGS; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700}.
FT   DOMAIN          34..109
FT                   /note="DEP"
FT                   /evidence="ECO:0000259|PROSITE:PS50186"
FT   DOMAIN          303..418
FT                   /note="RGS"
FT                   /evidence="ECO:0000259|PROSITE:PS50132"
FT   REGION          441..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        442..456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   466 AA;  53643 MW;  99675728D6EBA09C CRC64;
     MAMVTRCTPH GGCSRMQRPH LSKMERVVVS MQDPDQGVKM RSQRLLITVI PHAVAGRDLV
     EWLVQKFCIL EDEALHLGTL LAQHGYIYPL RESRDLTLRP DETPYRFQTP YFWTSTMWPA
     AELDYAIYLA KKNIQKQGAL VDYEKEHYAL LHKKINHAWD LVLMQAREQL RAAKQRRKGD
     RMVISCQEQT YWLVNKPPPG APNILEQGPE RGSYNPSHMQ MSSDFYKCEI ECFRKALGRN
     RVKSSACLEA YLKFSSQHGP HDPIMSGCLP SNPWITDDVT YWAMNAPNVA APTKLRVERW
     SFSFRELLDD PVGRAHFMDF LQKEFSAENL SFWEACEELR FGGQAQVPTL VDSVYQQFLA
     PGAARWINID SRTMERTLEG LRQPHRYVLD AAQLHIYMLM KKDSYPRFLK SDIYKGLLEE
     AVIPLETKRW PFPFLRKPLH SSPSPALQST PREPAATSSP EGADGE
//