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G3X8T9

- G3X8T9_MOUSE

UniProt

G3X8T9 - G3X8T9_MOUSE

Protein
Submitted name:

Serine (Or cysteine) peptidase inhibitor, clade A, member 3N, isoform CRA_a

Gene

Serpina3n

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 22 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: RefGenome

    GO - Biological processi

    1. cellular response to cAMP Source: Ensembl
    2. cellular response to glucocorticoid stimulus Source: Ensembl
    3. cellular response to interferon-gamma Source: Ensembl
    4. cellular response to interleukin-1 Source: Ensembl
    5. cellular response to interleukin-6 Source: Ensembl
    6. inflammatory response Source: Ensembl
    7. negative regulation of endopeptidase activity Source: RefGenome
    8. regulation of proteolysis Source: RefGenome
    9. response to cytokine Source: MGI
    10. response to lipopolysaccharide Source: Ensembl
    11. response to peptide hormone Source: MGI
    12. response to vitamin B6 Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Serine (Or cysteine) peptidase inhibitor, clade A, member 3N, isoform CRA_aImported
    Submitted name:
    Serine protease inhibitor A3NImported
    Gene namesi
    Name:Serpina3nImported
    ORF Names:mCG_3346Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:105045. Serpina3n.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: MGI
    2. extracellular space Source: Ensembl

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the serpin family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00740000115120.
    KOiK04525.
    OMAiVKFVPMS.
    OrthoDBiEOG78M027.
    TreeFamiTF343201.

    Family and domain databases

    InterProiIPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view]
    PANTHERiPTHR11461. PTHR11461. 1 hit.
    PfamiPF00079. Serpin. 1 hit.
    [Graphical view]
    SMARTiSM00093. SERPIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF56574. SSF56574. 1 hit.
    PROSITEiPS00284. SERPIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3X8T9-1 [UniParc]FASTAAdd to Basket

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    MAFIAALGLL MAGICPAVLC FPDGTLGMDA AVQEDHDNGT QLDSLTLASI    50
    NTDFAFSLYK ELVLKNPDKN IVFSPLSISA ALAVMSLGAK GNTLEEILEG 100
    LKFNLTETSE ADIHQGFGHL LQRLNQPKDQ VQISTGSALF IEKRQQILTE 150
    FQEKARALYQ AEAFTADFQQ PRQAKKLIND YVRKQTQGMI KELVSDLDKR 200
    TLMVLVNYIY FKAKWKVPFD PLDTFKSEFY AGKRRPVIVP MMSMEDLTTP 250
    YFRDEELFCT VVELKYTGNA SAMFILPDQG KMQQVEASLQ PETLRKWKNS 300
    LKPRMIDELH LPKFSISTDY SLEDVLSKLG IREVFSTQAD LSAITGTKDL 350
    RVSQVVHKAV LDVAETGTEA AAATGVKFVP MSAKLYPLTV YFNRPFLIMI 400
    FDTETEIAPF IAKIANPK 418
    Length:418
    Mass (Da):46,766
    Last modified:November 16, 2011 - v1
    Checksum:iF9B291DCDDAF76F3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC117194 Genomic DNA. No translation available.
    CH466549 Genomic DNA. Translation: EDL18789.1.
    RefSeqiNP_033278.2. NM_009252.2.
    UniGeneiMm.482074.

    Genome annotation databases

    EnsembliENSMUST00000021506; ENSMUSP00000021506; ENSMUSG00000021091.
    GeneIDi20716.
    KEGGimmu:20716.
    UCSCiuc007oxg.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC117194 Genomic DNA. No translation available.
    CH466549 Genomic DNA. Translation: EDL18789.1 .
    RefSeqi NP_033278.2. NM_009252.2.
    UniGenei Mm.482074.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000021506 ; ENSMUSP00000021506 ; ENSMUSG00000021091 .
    GeneIDi 20716.
    KEGGi mmu:20716.
    UCSCi uc007oxg.1. mouse.

    Organism-specific databases

    CTDi 20716.
    MGIi MGI:105045. Serpina3n.

    Phylogenomic databases

    GeneTreei ENSGT00740000115120.
    KOi K04525.
    OMAi VKFVPMS.
    OrthoDBi EOG78M027.
    TreeFami TF343201.

    Miscellaneous databases

    NextBioi 299305.
    SOURCEi Search...

    Family and domain databases

    InterProi IPR023795. Serpin_CS.
    IPR023796. Serpin_dom.
    IPR000215. Serpin_fam.
    [Graphical view ]
    PANTHERi PTHR11461. PTHR11461. 1 hit.
    Pfami PF00079. Serpin. 1 hit.
    [Graphical view ]
    SMARTi SM00093. SERPIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56574. SSF56574. 1 hit.
    PROSITEi PS00284. SERPIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
      Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
      , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
      Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MixedImported.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiG3X8T9_MOUSE
    AccessioniPrimary (citable) accession number: G3X8T9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 22 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3