ID   G3X8P5_MOUSE            Unreviewed;       618 AA.
AC   G3X8P5;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 83.
DE   SubName: Full=Solute carrier family 5 (sodium iodide symporter), member 5 {ECO:0000313|Ensembl:ENSMUSP00000000809.3};
GN   Name=Slc5a5 {ECO:0000313|Ensembl:ENSMUSP00000000809.3,
GN   ECO:0000313|MGI:MGI:2149330};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000000809.3, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000000809.3, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000000809.3,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000000809.3}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000000809.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=iodide(out) + 2 Na(+)(out) = iodide(in) + 2 Na(+)(in);
CC         Xref=Rhea:RHEA:71207, ChEBI:CHEBI:16382, ChEBI:CHEBI:29101;
CC         Evidence={ECO:0000256|ARBA:ARBA00036099};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC       family. {ECO:0000256|ARBA:ARBA00006434, ECO:0000256|RuleBase:RU362091}.
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DR   RefSeq; NP_444478.2; NM_053248.2.
DR   AlphaFoldDB; G3X8P5; -.
DR   SMR; G3X8P5; -.
DR   ProteomicsDB; 341084; -.
DR   Antibodypedia; 14944; 597 antibodies from 31 providers.
DR   DNASU; 114479; -.
DR   Ensembl; ENSMUST00000000809.3; ENSMUSP00000000809.3; ENSMUSG00000000792.3.
DR   GeneID; 114479; -.
DR   KEGG; mmu:114479; -.
DR   UCSC; uc009mbz.2; mouse.
DR   AGR; MGI:2149330; -.
DR   CTD; 6528; -.
DR   MGI; MGI:2149330; Slc5a5.
DR   VEuPathDB; HostDB:ENSMUSG00000000792; -.
DR   GeneTree; ENSGT00940000159489; -.
DR   HOGENOM; CLU_018808_11_1_1; -.
DR   OMA; GFFSHTM; -.
DR   OrthoDB; 3078791at2759; -.
DR   PhylomeDB; G3X8P5; -.
DR   TreeFam; TF316728; -.
DR   BioGRID-ORCS; 114479; 2 hits in 78 CRISPR screens.
DR   Proteomes; UP000000589; Chromosome 8.
DR   Bgee; ENSMUSG00000000792; Expressed in epithelium of stomach and 72 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR   GO; GO:0008507; F:sodium:iodide symporter activity; IEA:Ensembl.
DR   GO; GO:0071320; P:cellular response to cAMP; IEA:Ensembl.
DR   GO; GO:1904322; P:cellular response to forskolin; IEA:Ensembl.
DR   GO; GO:0071371; P:cellular response to gonadotropin stimulus; IEA:Ensembl.
DR   GO; GO:1904401; P:cellular response to Thyroid stimulating hormone; IEA:Ensembl.
DR   GO; GO:1904200; P:iodide transmembrane transport; IEA:Ensembl.
DR   GO; GO:0006590; P:thyroid hormone generation; IEA:InterPro.
DR   CDD; cd11503; SLC5sbd_NIS; 1.
DR   Gene3D; 1.20.1730.10; Sodium/glucose cotransporter; 1.
DR   InterPro; IPR038377; Na/Glc_symporter_sf.
DR   InterPro; IPR001734; Na/solute_symporter.
DR   InterPro; IPR018212; Na/solute_symporter_CS.
DR   InterPro; IPR035689; SLC5A5.
DR   NCBIfam; TIGR00813; sss; 1.
DR   PANTHER; PTHR42985; SODIUM-COUPLED MONOCARBOXYLATE TRANSPORTER; 1.
DR   PANTHER; PTHR42985:SF11; SODIUM_IODIDE COTRANSPORTER; 1.
DR   Pfam; PF00474; SSF; 1.
DR   PROSITE; PS00456; NA_SOLUT_SYMP_1; 1.
DR   PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE   1: Evidence at protein level;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|ProteomicsDB:G3X8P5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        17..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        56..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        87..110
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        131..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        162..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        192..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        242..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        282..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        342..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        392..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        419..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        444..466
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        523..544
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          571..618
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   618 AA;  65540 MW;  448AC5FE85A5118E CRC64;
     MEGAEAGARA TFGPWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG GRQLAAVPVG
     LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CVGQLLNSLL TALLFLPIFY RLGLTSTYQY
     LELRFSRAVR LCGTLQYLVA TMLYTGIVIY APALILNQVT GLDIWASLLS TGIICTLYTT
     VGGMKAVVWT DVFQVVVMLV GFWVILARGV MLMGGPWNVL SLAQNHSRIN LMDFDPDPRS
     RYTFWTFVVG GSLVWLSMYG VNQAQVQRYV ACHTERKAKL ALLVNQLGLF LIVASAACCG
     IVMFVYYKDC DPLLTGRIAA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG TLSTASTSIN
     AMAAVTVEDL IKPRMPSLAP RKLVFISKGL SFIYGSTCLT VAALSSLLGG GVLQGSFTVM
     GVISGPLLGA FTLGMLLPAC NTPGVLSGLT AGLAVSLWVA VGATLYPPGE QTMGVLPTSA
     AGCTNASVLP SPPGAANTSR GIPSSGMDSG RPAFADTFYA VSYLYYGALG TLTTMLCGAL
     ISYLTGPTKR SSLGPGLLWW DLARQTASVA PKEDTTTLED SLVKGPEDIP AATKKPPGFR
     PEAETHPLYL GHDAETNL
//