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Protein
Submitted name:

Sodium/iodide cotransporter

Gene

Slc5a5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

  1. iodide transmembrane transporter activity Source: MGI
  2. sodium:iodide symporter activity Source: MGI
  3. symporter activity Source: MGI

GO - Biological processi

  1. cellular response to cAMP Source: Ensembl
  2. cellular response to gonadotropin stimulus Source: Ensembl
  3. iodide transport Source: MGI
  4. sodium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Biological processi

TransportUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_219697. Thyroxine biosynthesis.
REACT_251149. Organic anion transporters.

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium/iodide cotransporterImported
Submitted name:
Solute carrier family 5 (Sodium iodide symporter), member 5Imported
Gene namesi
Name:Slc5a5Imported
ORF Names:mCG_14796Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:2149330. Slc5a5.

Subcellular locationi

Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. nucleus Source: MGI
  4. vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Structurei

3D structure databases

ProteinModelPortaliG3X8P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]UniRule annotation

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118955.
KOiK14385.
OMAiATFGAWD.
OrthoDBiEOG70PBX7.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3X8P5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGAEAGARA TFGPWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG
60 70 80 90 100
GRQLAAVPVG LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CVGQLLNSLL
110 120 130 140 150
TALLFLPIFY RLGLTSTYQY LELRFSRAVR LCGTLQYLVA TMLYTGIVIY
160 170 180 190 200
APALILNQVT GLDIWASLLS TGIICTLYTT VGGMKAVVWT DVFQVVVMLV
210 220 230 240 250
GFWVILARGV MLMGGPWNVL SLAQNHSRIN LMDFDPDPRS RYTFWTFVVG
260 270 280 290 300
GSLVWLSMYG VNQAQVQRYV ACHTERKAKL ALLVNQLGLF LIVASAACCG
310 320 330 340 350
IVMFVYYKDC DPLLTGRIAA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG
360 370 380 390 400
TLSTASTSIN AMAAVTVEDL IKPRMPSLAP RKLVFISKGL SFIYGSTCLT
410 420 430 440 450
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FTLGMLLPAC NTPGVLSGLT
460 470 480 490 500
AGLAVSLWVA VGATLYPPGE QTMGVLPTSA AGCTNASVLP SPPGAANTSR
510 520 530 540 550
GIPSSGMDSG RPAFADTFYA VSYLYYGALG TLTTMLCGAL ISYLTGPTKR
560 570 580 590 600
SSLGPGLLWW DLARQTASVA PKEDTTTLED SLVKGPEDIP AATKKPPGFR
610
PEAETHPLYL GHDAETNL
Length:618
Mass (Da):65,540
Last modified:November 16, 2011 - v1
Checksum:i448AC5FE85A5118E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019302 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28884.1.
RefSeqiNP_444478.2. NM_053248.2.
UniGeneiMm.172923.

Genome annotation databases

EnsembliENSMUST00000000809; ENSMUSP00000000809; ENSMUSG00000000792.
GeneIDi114479.
KEGGimmu:114479.
UCSCiuc009mbz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019302 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28884.1.
RefSeqiNP_444478.2. NM_053248.2.
UniGeneiMm.172923.

3D structure databases

ProteinModelPortaliG3X8P5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000809; ENSMUSP00000000809; ENSMUSG00000000792.
GeneIDi114479.
KEGGimmu:114479.
UCSCiuc009mbz.2. mouse.

Organism-specific databases

CTDi6528.
MGIiMGI:2149330. Slc5a5.

Phylogenomic databases

GeneTreeiENSGT00760000118955.
KOiK14385.
OMAiATFGAWD.
OrthoDBiEOG70PBX7.
TreeFamiTF316728.

Enzyme and pathway databases

ReactomeiREACT_219697. Thyroxine biosynthesis.
REACT_251149. Organic anion transporters.

Miscellaneous databases

NextBioi368443.
SOURCEiSearch...

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
IPR019900. Na/solute_symporter_subgr.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome."
    Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R., Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A., Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.
    , Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K., Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J., Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R., Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H., Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A., Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A., Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C., Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C., Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B., Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E., Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R., Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C., Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L., Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S., Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L., Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R., Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R., Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J., Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L., Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C., Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A., Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H., Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L., Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M., Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K., Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S., Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J., Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G., Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.
    Science 296:1661-1671(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MixedImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiG3X8P5_MOUSE
AccessioniPrimary (citable) accession number: G3X8P5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 4, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.