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Protein
Submitted name:

Sodium/iodide cotransporter

Gene

Slc5a5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-209968. Thyroxine biosynthesis.
R-MMU-428643. Organic anion transporters.

Names & Taxonomyi

Protein namesi
Submitted name:
Sodium/iodide cotransporterImported
Submitted name:
Solute carrier family 5 (Sodium iodide symporter), member 5Imported
Gene namesi
Name:Slc5a5Imported
ORF Names:mCG_14796Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2149330. Slc5a5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 36HelicalSequence analysisAdd BLAST20
Transmembranei56 – 75HelicalSequence analysisAdd BLAST20
Transmembranei87 – 110HelicalSequence analysisAdd BLAST24
Transmembranei131 – 156HelicalSequence analysisAdd BLAST26
Transmembranei162 – 180HelicalSequence analysisAdd BLAST19
Transmembranei192 – 211HelicalSequence analysisAdd BLAST20
Transmembranei242 – 261HelicalSequence analysisAdd BLAST20
Transmembranei282 – 307HelicalSequence analysisAdd BLAST26
Transmembranei342 – 371HelicalSequence analysisAdd BLAST30
Transmembranei392 – 413HelicalSequence analysisAdd BLAST22
Transmembranei419 – 437HelicalSequence analysisAdd BLAST19
Transmembranei444 – 466HelicalSequence analysisAdd BLAST23
Transmembranei523 – 544HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000000792.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000809.

Family & Domainsi

Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
KOiK14385.
OMAiATFGAWD.
OrthoDBiEOG091G07OC.
TreeFamiTF316728.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3X8P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGAEAGARA TFGPWDYGVF ATMLLVSTGI GLWVGLARGG QRSADDFFTG
60 70 80 90 100
GRQLAAVPVG LSLAASFMSA VQVLGVPAEA ARYGLKFLWM CVGQLLNSLL
110 120 130 140 150
TALLFLPIFY RLGLTSTYQY LELRFSRAVR LCGTLQYLVA TMLYTGIVIY
160 170 180 190 200
APALILNQVT GLDIWASLLS TGIICTLYTT VGGMKAVVWT DVFQVVVMLV
210 220 230 240 250
GFWVILARGV MLMGGPWNVL SLAQNHSRIN LMDFDPDPRS RYTFWTFVVG
260 270 280 290 300
GSLVWLSMYG VNQAQVQRYV ACHTERKAKL ALLVNQLGLF LIVASAACCG
310 320 330 340 350
IVMFVYYKDC DPLLTGRIAA PDQYMPLLVL DIFEDLPGVP GLFLACAYSG
360 370 380 390 400
TLSTASTSIN AMAAVTVEDL IKPRMPSLAP RKLVFISKGL SFIYGSTCLT
410 420 430 440 450
VAALSSLLGG GVLQGSFTVM GVISGPLLGA FTLGMLLPAC NTPGVLSGLT
460 470 480 490 500
AGLAVSLWVA VGATLYPPGE QTMGVLPTSA AGCTNASVLP SPPGAANTSR
510 520 530 540 550
GIPSSGMDSG RPAFADTFYA VSYLYYGALG TLTTMLCGAL ISYLTGPTKR
560 570 580 590 600
SSLGPGLLWW DLARQTASVA PKEDTTTLED SLVKGPEDIP AATKKPPGFR
610
PEAETHPLYL GHDAETNL
Length:618
Mass (Da):65,540
Last modified:November 16, 2011 - v1
Checksum:i448AC5FE85A5118E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019302 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28884.1.
RefSeqiNP_444478.2. NM_053248.2.
UniGeneiMm.172923.

Genome annotation databases

EnsembliENSMUST00000000809; ENSMUSP00000000809; ENSMUSG00000000792.
GeneIDi114479.
KEGGimmu:114479.
UCSCiuc009mbz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC019302 Genomic DNA. No translation available.
CH466569 Genomic DNA. Translation: EDL28884.1.
RefSeqiNP_444478.2. NM_053248.2.
UniGeneiMm.172923.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000809.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000809; ENSMUSP00000000809; ENSMUSG00000000792.
GeneIDi114479.
KEGGimmu:114479.
UCSCiuc009mbz.2. mouse.

Organism-specific databases

CTDi6528.
MGIiMGI:2149330. Slc5a5.

Phylogenomic databases

eggNOGiKOG2349. Eukaryota.
COG0591. LUCA.
GeneTreeiENSGT00760000118955.
KOiK14385.
OMAiATFGAWD.
OrthoDBiEOG091G07OC.
TreeFamiTF316728.

Enzyme and pathway databases

ReactomeiR-MMU-209968. Thyroxine biosynthesis.
R-MMU-428643. Organic anion transporters.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000792.

Family and domain databases

InterProiIPR001734. Na/solute_symporter.
IPR018212. Na/solute_symporter_CS.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 2 hits.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00813. sss. 1 hit.
PROSITEiPS00456. NA_SOLUT_SYMP_1. 1 hit.
PS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG3X8P5_MOUSE
AccessioniPrimary (citable) accession number: G3X8P5
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 2, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.