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Protein
Submitted name:

Uncharacterized protein

Gene

SETDB1

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: InterPro
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:SETDB1Imported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
ProteomesiUP000007648 Componenti: Unplaced

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00780000121845.
KOiK11421.

Family and domain databases

InterProiIPR016177. DNA-bd_dom.
IPR025796. Hist-Lys_N-MeTrfase_SETDB1.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00391. MBD. 1 hit.
SM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00333. TUDOR. 2 hits.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51573. SAM_MT43_SUVAR39_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3WHI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSFPGCFGL GAAAAGMEPQ EIAELQQAVV EELGISMEEL RQFIDEELEK
60 70 80 90 100
MDCVKQRKRQ LAELESWVVQ KETEVAHVDE LFDEASRAVT NCETLVKDFY
110 120 130 140 150
SKLGLQYRES SSEDEASKPT EVIEIPDEDD DVLSVDSGDA GSRTPKDQKL
160 170 180 190 200
REAMAALRKS AQDVQKFMDA VNKKTSSQDL NKGALGQVPV ELSKDGDLVV
210 220 230 240 250
SMRILGKKRT KTWHKGTLIA IQTVGAGRKF KVKFDNKGKS LLSGNHIAYD
260 270 280 290 300
YHPPADKLYV GSRVVAKYKD GNQVWLYAGI VAETPNVKNK LRFLIFFDDG
310 320 330 340 350
YASYVTQSEL YPICRPLKKT WEDIEDISCR DFIEEYITAY PNRPMVLLKS
360 370 380 390 400
GQLIKTEWEG TWWKSRVEEV DGSLVKILFL DDKRCEWIYR GSTRLEPMFS
410 420 430 440 450
MKTSTASTLE KKQGGQLRTR PNMGAVRSKG PVVQYTQDLT GTGTQFKPLE
460 470 480 490 500
PPRTPSLPAP TLSPQVADLE SLESQLAQAR KQVAKKSTSF RLGSVGSGHS
510 520 530 540 550
SPTSPGLNEA VPGGKSAVGQ TVRLTPGSAT PGPTFPAFHG MLERAPAEPS
560 570 580 590 600
YRAPMEKLFY LPHACSHTCL TRVRPVSNAQ YRGKNPLLVP LLYDFRRMTA
610 620 630 640 650
RRRVNRKMGF HVIYKTPCGL CLRTMNEIER YLFETSCDFL FLEMFCLDPY
660 670 680 690 700
VLVDRKFQPY KPFYYILDIT HGQEDVPLSC VNEIDTTPPP QVAYSKERIP
710 720 730 740 750
GKGVFINTGW EFLVGCDCKD GCRDKSKCAC HQLTIQATAC TPGGQINPNS
760 770 780 790 800
GYQHKRLDEC LPTGVYECNK RCKCNINMCT NRLVQHGLQV RLQLFKTQNK
810 820 830 840 850
GWGIRCLDDI ARGSFVCIYA GKILTDDFAD KEGLEMGDEY FANLDHIESV
860 870 880 890 900
ENFKEGYESD APCSSDSSGV DLKDQEDGNS GTEDPEESND DSSDDNFCKD
910 920 930 940 950
EDFSTSSVWR SYATRRQTRG QKENGTSETA SKDSRPTDSG TPHLSAPQTS
960 970 980 990 1000
MGGCKPPSSE DTPKNKVATW LSCNNVSDSS FADSDSRSSF RTSEGGDGRA
1010 1020 1030 1040 1050
GVGRGDGEKP SVSGLGVKEE GDIKAPKKEE SDEQSKIVLS SEGSRTFGYN
1060 1070 1080 1090 1100
PSPLKTEGIK GPPSKTNIHQ ARRLVAPAQA NPDDVLTLSS STESEGESGT
1110 1120 1130 1140 1150
SRKPVAGQAP ATAADSDDIQ TISSGSDGED YEDKKNLSGP IKRQVAVKST
1160 1170 1180 1190 1200
RGFALKSTHG IAIKSTNMAS ADKGESVPVR KNTRQFYDGE ESCYIIDAKL
1210 1220 1230 1240 1250
EGNLGRYLNH SCSPNLFVQN VFVDTHDLRF PWVAFFASKR IRAGTELTWD
1260 1270
YNYEVGSVEG KELLCCCGAI ECRGRLL
Length:1,277
Mass (Da):141,281
Last modified:November 15, 2011 - v1
Checksum:i151246E30F22C589
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01176895 Genomic DNA. No translation available.
AEFK01176896 Genomic DNA. No translation available.
RefSeqiXP_003770007.1. XM_003769959.1.

Genome annotation databases

EnsembliENSSHAT00000015012; ENSSHAP00000014887; ENSSHAG00000012701.
GeneIDi100928904.
KEGGishr:100928904.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01176895 Genomic DNA. No translation available.
AEFK01176896 Genomic DNA. No translation available.
RefSeqiXP_003770007.1. XM_003769959.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSHAT00000015012; ENSSHAP00000014887; ENSSHAG00000012701.
GeneIDi100928904.
KEGGishr:100928904.

Organism-specific databases

CTDi9869.

Phylogenomic databases

GeneTreeiENSGT00780000121845.
KOiK11421.

Family and domain databases

InterProiIPR016177. DNA-bd_dom.
IPR025796. Hist-Lys_N-MeTrfase_SETDB1.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR003606. Pre-SET_Zn-bd_sub.
IPR001214. SET_dom.
IPR002999. Tudor.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00391. MBD. 1 hit.
SM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SM00333. TUDOR. 2 hits.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51573. SAM_MT43_SUVAR39_1. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (AUG-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiG3WHI2_SARHA
AccessioniPrimary (citable) accession number: G3WHI2
Entry historyi
Integrated into UniProtKB/TrEMBL: November 15, 2011
Last sequence update: November 15, 2011
Last modified: March 3, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.