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Protein

Isocitrate dehydrogenase [NADP]

Gene

IDH1

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei77 – 771SubstrateUniRule annotation
Binding sitei82 – 821NADPUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei132 – 1321SubstrateUniRule annotation
Sitei139 – 1391Critical for catalysisUniRule annotation
Sitei212 – 2121Critical for catalysisUniRule annotation
Metal bindingi252 – 2521Magnesium or manganeseUniRule annotation
Binding sitei260 – 2601NADPUniRule annotation
Metal bindingi275 – 2751Magnesium or manganeseUniRule annotation
Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 773NADPUniRule annotation
Nucleotide bindingi310 – 3156NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: Ensembl
  3. NAD binding Source: InterPro

GO - Biological processi

  1. 2-oxoglutarate metabolic process Source: Ensembl
  2. glutathione metabolic process Source: Ensembl
  3. isocitrate metabolic process Source: InterPro
  4. response to oxidative stress Source: Ensembl
  5. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:IDH1Imported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
ProteomesiUP000007648: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. mitochondrion Source: Ensembl
  4. peroxisome Source: Ensembl
Complete GO annotation...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 1007Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000012547.
InParanoidiG3W9L8.
KOiK00031.
OMAiHNFESCG.
OrthoDBiEOG7QNVKS.
TreeFamiTF300428.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3W9L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKINGGSV VEMQGDEMTR VIWELIKDKL IFPYVNLDLH SYDLGMENRD
60 70 80 90 100
ATDDKVTIEA AEAIKKYNVG IKCATITPDE KRVEEFKLKK MWKSPNGTIR
110 120 130 140 150
NILGGTVFRE AIICKNIPRL VNGWVKPIII GRHAYGDQYR ATDFVVPGPG
160 170 180 190 200
KVEITYTPSD GGEPMTYMVH DFEDCGGVAM GMYNLDHSIK DFAHSSFQMA
210 220 230 240 250
LSKGWPLYMS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE AKKIWYEHRL
260 270 280 290 300
IDDMVAQALK SEGGFVWACK NYDGDVQSDS IAQGYGSLGM MTSVLICPDG
310 320 330 340 350
KTVESEAAHG TVTRHYRMHQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNA
360 370 380 390 400
ELSKFATILE EVCIETIESG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK
410
LGENLKAKLS QAKL
Length:414
Mass (Da):46,710
Last modified:November 16, 2011 - v1
Checksum:iE47A0AE3AD783201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01133401 Genomic DNA. No translation available.
AEFK01133402 Genomic DNA. No translation available.
RefSeqiXP_003766019.1. XM_003765971.1.

Genome annotation databases

EnsembliENSSHAT00000012221; ENSSHAP00000012123; ENSSHAG00000010387.
GeneIDi100933478.
KEGGishr:100933478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01133401 Genomic DNA. No translation available.
AEFK01133402 Genomic DNA. No translation available.
RefSeqiXP_003766019.1. XM_003765971.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSHAT00000012221; ENSSHAP00000012123; ENSSHAG00000010387.
GeneIDi100933478.
KEGGishr:100933478.

Organism-specific databases

CTDi3417.

Phylogenomic databases

GeneTreeiENSGT00390000012547.
InParanoidiG3W9L8.
KOiK00031.
OMAiHNFESCG.
OrthoDBiEOG7QNVKS.
TreeFamiTF300428.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (SEP-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiG3W9L8_SARHA
AccessioniPrimary (citable) accession number: G3W9L8
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 4, 2015
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.