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G3W9L8 (G3W9L8_SARHA) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSSHAP00000012123

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding310 – 3156NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2521Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2751Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2601NADP By similarity PIRSR PIRSR000108-4
Binding site3281NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2121Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
G3W9L8 [UniParc].

Last modified November 16, 2011. Version 1.
Checksum: E47A0AE3AD783201

FASTA41446,710
        10         20         30         40         50         60 
MSKKINGGSV VEMQGDEMTR VIWELIKDKL IFPYVNLDLH SYDLGMENRD ATDDKVTIEA 

        70         80         90        100        110        120 
AEAIKKYNVG IKCATITPDE KRVEEFKLKK MWKSPNGTIR NILGGTVFRE AIICKNIPRL 

       130        140        150        160        170        180 
VNGWVKPIII GRHAYGDQYR ATDFVVPGPG KVEITYTPSD GGEPMTYMVH DFEDCGGVAM 

       190        200        210        220        230        240 
GMYNLDHSIK DFAHSSFQMA LSKGWPLYMS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE 

       250        260        270        280        290        300 
AKKIWYEHRL IDDMVAQALK SEGGFVWACK NYDGDVQSDS IAQGYGSLGM MTSVLICPDG 

       310        320        330        340        350        360 
KTVESEAAHG TVTRHYRMHQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNA ELSKFATILE 

       370        380        390        400        410 
EVCIETIESG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK LGENLKAKLS QAKL 

« Hide

References

« Hide 'large scale' references
[1]"Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil)."
Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P., Tindall E.A. expand/collapse author list , Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M., Jones M.E., Schuster S.C.
Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]Ensembl
Submitted (SEP-2011) to UniProtKB
Cited for: IDENTIFICATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AEFK01133401 Genomic DNA. No translation available.
AEFK01133402 Genomic DNA. No translation available.
RefSeqXP_003766019.1. XM_003765971.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSHAT00000012221; ENSSHAP00000012123; ENSSHAG00000010387.
GeneID100933478.
KEGGshr:100933478.

Organism-specific databases

CTD3417.

Phylogenomic databases

GeneTreeENSGT00390000012547.
KOK00031.
OMASCGGVAM.
OrthoDBEOG7QNVKS.
TreeFamTF300428.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG3W9L8_SARHA
AccessionPrimary (citable) accession number: G3W9L8
Entry history
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 9, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)