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Protein

Isocitrate dehydrogenase [NADP]

Gene

IDH1

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei77SubstrateUniRule annotation1
Binding sitei82NADPUniRule annotation1
Binding sitei109SubstrateUniRule annotation1
Binding sitei132SubstrateUniRule annotation1
Sitei139Critical for catalysisUniRule annotation1
Sitei212Critical for catalysisUniRule annotation1
Metal bindingi252Magnesium or manganeseUniRule annotation1
Binding sitei260NADPUniRule annotation1
Metal bindingi275Magnesium or manganeseUniRule annotation1
Binding sitei328NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 77NADPUniRule annotation3
Nucleotide bindingi310 – 315NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandMagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:IDH1Imported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
Proteomesi
  • UP000007648 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000012123

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 401Iso_dhInterPro annotationAdd BLAST393

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 100Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1526 Eukaryota
COG0538 LUCA
GeneTreeiENSGT00390000012547
InParanoidiG3W9L8
KOiK00031
OMAiAMGMYNQ
OrthoDBiEOG091G06IY
TreeFamiTF300428

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004790 Isocitrate_DH_NADP
IPR024084 IsoPropMal-DH-like_dom
PANTHERiPTHR11822 PTHR11822, 1 hit
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
PIRSFiPIRSF000108 IDH_NADP, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00127 nadp_idh_euk, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequencei

Sequence statusi: Complete.

G3W9L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKKINGGSV VEMQGDEMTR VIWELIKDKL IFPYVNLDLH SYDLGMENRD
60 70 80 90 100
ATDDKVTIEA AEAIKKYNVG IKCATITPDE KRVEEFKLKK MWKSPNGTIR
110 120 130 140 150
NILGGTVFRE AIICKNIPRL VNGWVKPIII GRHAYGDQYR ATDFVVPGPG
160 170 180 190 200
KVEITYTPSD GGEPMTYMVH DFEDCGGVAM GMYNLDHSIK DFAHSSFQMA
210 220 230 240 250
LSKGWPLYMS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE AKKIWYEHRL
260 270 280 290 300
IDDMVAQALK SEGGFVWACK NYDGDVQSDS IAQGYGSLGM MTSVLICPDG
310 320 330 340 350
KTVESEAAHG TVTRHYRMHQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNA
360 370 380 390 400
ELSKFATILE EVCIETIESG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK
410
LGENLKAKLS QAKL
Length:414
Mass (Da):46,710
Last modified:November 16, 2011 - v1
Checksum:iE47A0AE3AD783201
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01133401 Genomic DNA No translation available.
AEFK01133402 Genomic DNA No translation available.
RefSeqiXP_003766019.1, XM_003765971.2
XP_012401888.1, XM_012546434.1

Genome annotation databases

EnsembliENSSHAT00000012221; ENSSHAP00000012123; ENSSHAG00000010387
GeneIDi100933478
KEGGishr:100933478

Similar proteinsi

Entry informationi

Entry nameiG3W9L8_SARHA
AccessioniPrimary (citable) accession number: G3W9L8
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: May 23, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health