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G3W9L8

- G3W9L8_SARHA

UniProt

G3W9L8 - G3W9L8_SARHA

Protein

Isocitrate dehydrogenase [NADP]

Gene

IDH1

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei77 – 771Substrate
    Binding sitei82 – 821NADPUniRule annotation
    Binding sitei109 – 1091Substrate
    Binding sitei132 – 1321SubstrateUniRule annotation
    Sitei139 – 1391Critical for catalysisUniRule annotation
    Sitei212 – 2121Critical for catalysisUniRule annotation
    Metal bindingi252 – 2521Magnesium or manganeseUniRule annotation
    Binding sitei260 – 2601NADPUniRule annotation
    Metal bindingi275 – 2751Magnesium or manganeseUniRule annotation
    Binding sitei328 – 3281NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 773NADPUniRule annotation
    Nucleotide bindingi310 – 3156NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: Ensembl
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. 2-oxoglutarate metabolic process Source: Ensembl
    2. glutathione metabolic process Source: Ensembl
    3. isocitrate metabolic process Source: InterPro
    4. response to oxidative stress Source: Ensembl
    5. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:IDH1Imported
    OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
    Taxonomic identifieri9305 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
    ProteomesiUP000007648: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. mitochondrion Source: Ensembl

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 1007Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    GeneTreeiENSGT00390000012547.
    KOiK00031.
    OMAiSCGGVAM.
    OrthoDBiEOG7QNVKS.
    TreeFamiTF300428.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3W9L8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKKINGGSV VEMQGDEMTR VIWELIKDKL IFPYVNLDLH SYDLGMENRD    50
    ATDDKVTIEA AEAIKKYNVG IKCATITPDE KRVEEFKLKK MWKSPNGTIR 100
    NILGGTVFRE AIICKNIPRL VNGWVKPIII GRHAYGDQYR ATDFVVPGPG 150
    KVEITYTPSD GGEPMTYMVH DFEDCGGVAM GMYNLDHSIK DFAHSSFQMA 200
    LSKGWPLYMS TKNTILKKYD GRFKDIFQEI YDKQYKSQFE AKKIWYEHRL 250
    IDDMVAQALK SEGGFVWACK NYDGDVQSDS IAQGYGSLGM MTSVLICPDG 300
    KTVESEAAHG TVTRHYRMHQ KGQETSTNPI ASIFAWTRGL AHRAKLDNNA 350
    ELSKFATILE EVCIETIESG FMTKDLAACI KGLPNVQRSD YLNTFEFMDK 400
    LGENLKAKLS QAKL 414
    Length:414
    Mass (Da):46,710
    Last modified:November 16, 2011 - v1
    Checksum:iE47A0AE3AD783201
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AEFK01133401 Genomic DNA. No translation available.
    AEFK01133402 Genomic DNA. No translation available.
    RefSeqiXP_003766019.1. XM_003765971.1.

    Genome annotation databases

    EnsembliENSSHAT00000012221; ENSSHAP00000012123; ENSSHAG00000010387.
    GeneIDi100933478.
    KEGGishr:100933478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AEFK01133401 Genomic DNA. No translation available.
    AEFK01133402 Genomic DNA. No translation available.
    RefSeqi XP_003766019.1. XM_003765971.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSHAT00000012221 ; ENSSHAP00000012123 ; ENSSHAG00000010387 .
    GeneIDi 100933478.
    KEGGi shr:100933478.

    Organism-specific databases

    CTDi 3417.

    Phylogenomic databases

    GeneTreei ENSGT00390000012547.
    KOi K00031.
    OMAi SCGGVAM.
    OrthoDBi EOG7QNVKS.
    TreeFami TF300428.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiG3W9L8_SARHA
    AccessioniPrimary (citable) accession number: G3W9L8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3