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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 2

Gene

PCSK2

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS08.073

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 2Imported
Gene namesi
Name:PCSK2Imported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
Proteomesi
  • UP000007648 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_500345892026 – 639Sequence analysisAdd BLAST614

Interactioni

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000012098

Structurei

3D structure databases

ProteinModelPortaliG3W9J3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini462 – 598P/Homo BInterPro annotationAdd BLAST137

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili610 – 630Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
KOG3526 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00750000117358
InParanoidiG3W9J3
KOiK01360
OMAiPQRGVLK
OrthoDBiEOG091G05HI
TreeFamiTF314277

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.2601 hit
3.30.70.8501 hit
3.40.50.2001 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

G3W9J3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQGGSVSPQW KVAVVLLCIM IFASAERPIF TNQFLVELHT GGEEEARQVA
60 70 80 90 100
AEHGFSGIRK LPFTGGLYHF YHNGLAKTKR RRSLPHKQKL ETDPRVKMAL
110 120 130 140 150
QQEGFDRKKR GYRDINEIDI NMNDPLFTKQ WYLINTGQAD GTPGLDLNVA
160 170 180 190 200
EAWELGYTGK GVTIGIMDDG IDYLHPDLAA NYNAEASYDF SSNDPYPYPR
210 220 230 240 250
YTDDWFNSHG TRCAGEVSAA ANNNICGVGV AYNSKVAGIR MLDQPFMTDI
260 270 280 290 300
IEASSISHMP QVIDIYSASW GPTDNGKTVD GPRELTLQAM ADGVNKGRGG
310 320 330 340 350
KGSIYVWASG DGGSYDDCNC DGYASSMWTI SINSAINDGR TALYDESCSS
360 370 380 390 400
TLASTFSNGR KRNPEAGVAT TDLYGNCTLR HSGTSAAAPE AAGVFALALE
410 420 430 440 450
ANRELTWRDM QHLTVLTSKR NQLHDEVHQW RRNGVGLEFN HLFGYGVLDA
460 470 480 490 500
GAMVKMAKDW KTVPERFHCV GGSVQEPEKI PSNNKLVLTL TTDACEGKDN
510 520 530 540 550
FVRYLEHVQA VITVNATRRG DLNINMTSPM GTKSILLSRR PRDDDSKVGF
560 570 580 590 600
DKWPFMTTHT WGEDARGTWI LEIGFVGNAP QRGVLKEWTL MLHGTQSAPY
610 620 630
IDQVVKDYQS KLAMSKKEEL EEELDEAVER SLKSILSKN
Length:639
Mass (Da):70,745
Last modified:November 16, 2011 - v1
Checksum:i75277487BA05FE4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01029592 Genomic DNA No translation available.
AEFK01029593 Genomic DNA No translation available.
AEFK01029594 Genomic DNA No translation available.
AEFK01029595 Genomic DNA No translation available.
AEFK01029596 Genomic DNA No translation available.
AEFK01029597 Genomic DNA No translation available.
AEFK01029598 Genomic DNA No translation available.
AEFK01029599 Genomic DNA No translation available.
AEFK01029600 Genomic DNA No translation available.
AEFK01029601 Genomic DNA No translation available.
RefSeqiXP_003758218.1, XM_003758170.2

Genome annotation databases

EnsembliENSSHAT00000012196; ENSSHAP00000012098; ENSSHAG00000010370
GeneIDi100925659
KEGGishr:100925659

Similar proteinsi

Entry informationi

Entry nameiG3W9J3_SARHA
AccessioniPrimary (citable) accession number: G3W9J3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported