Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hexokinase

Gene

HK2

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: Ensembl

GO - Biological processi

  1. apoptotic mitochondrial changes Source: Ensembl
  2. glucose metabolic process Source: Ensembl
  3. glycolytic process Source: UniProtKB-KW
  4. regulation of glucose import Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:HK2Imported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
ProteomesiUP000007648 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial outer membrane Source: Ensembl
Complete GO annotation...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 2 hexokinase type-1 domains.UniRule annotation
Contains 2 hexokinase type-2 domains.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017159.
InParanoidiG3W8B7.
KOiK00844.
OMAiHHLGLES.
OrthoDBiEOG7S21X5.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

G3W8B7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIASHLLAYF FTELNHDQVQ KVDQYLYHMR LSDETLEEVS KRFRKEMEKG
60 70 80 90 100
LGADTHPTAS VKMLPTFVRS TPDGTEDGDF LALDLGGTNF RVLRVRVTDN
110 120 130 140 150
GLQKVEMENQ IYAIPEAIMR GSGTQLFDHI AECLANFMDK LQIKNKKLPL
160 170 180 190 200
GFTFSFPCHQ TKLDESYLVS WTKGFKSSGV EGRDVVSLIR KAIQRRGDFD
210 220 230 240 250
IDIVAVVNDT VGTMMTCGYD DQNCEIGLIV GTGTNACYME EMRYIDTVEG
260 270 280 290 300
DEGRMCINME WGAFGDDGVL NDIRTEFDRE IDMGSLNPGK QLFEKMISGM
310 320 330 340 350
YMGELVRLIL VKMAKEELLF GGKLSPELLT TGRFETKDVS DIEGEKDGIK
360 370 380 390 400
KALEILTRLG LQPSQEDCVA THRICQIVST RSANLCAATL AAVLRRIKEN
410 420 430 440 450
KGEDRLRSTI GVDGSVYKKH PHFAKRLHKA VRRLVPDCDV RFLRSEDGSG
460 470 480 490 500
KGAAMVTAVA YRLADQHRAR QKTLEALNLS HDQLLEVKRR MKREIELGLG
510 520 530 540 550
KDTHAAASVK MLPTYVCATP DGTEKGDFLA LDLGGTNFRV LLVRVRNGMR
560 570 580 590 600
RGVEMHNKIY SIPQEVMHGT GDELFDHIVQ CIADFLEYMG MKGVSLPLGF
610 620 630 640 650
TFSFPCQQNR LDESILLKWT KGFKATGCEG EDVVGLLKEA IHRREEFDLD
660 670 680 690 700
VVAVVNDTVG TMMTCGYEDP QCEVGLIVGT GTNACYMEEM RNIELVEGDE
710 720 730 740 750
GRMCVNMEWG AFGDNGSLDD ILTEFDLAVD ELSLNPGKQR FEKMISGMYL
760 770 780 790 800
GEIVRNILIN FTKRGLLFRG RISERLKTRG IFETKFLSQI ESDCLALLQV
810 820 830 840 850
RTILRHLGLE STCDDSIIVK EVCTVVARRA AQLCGAGMAA VVDKIRENRQ
860 870 880 890 900
LDTLKITVGV DGTLYKLHPH FAKVMHATVK ELAPKCDVSF LESEDGSGKG
910
AALITAVACR IRDAGQR
Length:917
Mass (Da):102,358
Last modified:November 16, 2011 - v1
Checksum:i264587C5AAE77E39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01027480 Genomic DNA. No translation available.
AEFK01027481 Genomic DNA. No translation available.
AEFK01027482 Genomic DNA. No translation available.
AEFK01027483 Genomic DNA. No translation available.
AEFK01027484 Genomic DNA. No translation available.
RefSeqiXP_003758010.1. XM_003757962.1.

Genome annotation databases

EnsembliENSSHAT00000011768; ENSSHAP00000011672; ENSSHAG00000010027.
GeneIDi100930478.
KEGGishr:100930478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01027480 Genomic DNA. No translation available.
AEFK01027481 Genomic DNA. No translation available.
AEFK01027482 Genomic DNA. No translation available.
AEFK01027483 Genomic DNA. No translation available.
AEFK01027484 Genomic DNA. No translation available.
RefSeqiXP_003758010.1. XM_003757962.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSHAT00000011768; ENSSHAP00000011672; ENSSHAG00000010027.
GeneIDi100930478.
KEGGishr:100930478.

Organism-specific databases

CTDi3099.

Phylogenomic databases

GeneTreeiENSGT00390000017159.
InParanoidiG3W8B7.
KOiK00844.
OMAiHHLGLES.
OrthoDBiEOG7S21X5.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (AUG-2011) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiG3W8B7_SARHA
AccessioniPrimary (citable) accession number: G3W8B7
Entry historyi
Integrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 1, 2015
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.