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Protein

Sodium/potassium-transporting ATPase subunit alpha

Gene

ATP1A2

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processIon transport, Potassium transportUniRule annotation, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alphaUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:ATP1A2Imported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
Proteomesi
  • UP000007648 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei94 – 116HelicalUniRule annotationAdd BLAST23
Transmembranei128 – 147HelicalUniRule annotationAdd BLAST20
Transmembranei289 – 313HelicalUniRule annotationAdd BLAST25
Transmembranei319 – 342HelicalUniRule annotationAdd BLAST24
Transmembranei855 – 876HelicalUniRule annotationAdd BLAST22
Transmembranei955 – 981HelicalUniRule annotationAdd BLAST27
Transmembranei987 – 1003HelicalUniRule annotationAdd BLAST17

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000010656

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 114Cation_ATPase_NInterPro annotationAdd BLAST75

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili23 – 43Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0203 Eukaryota
COG0474 LUCA
GeneTreeiENSGT00890000139334
InParanoidiG3W5F1
OMAiYVFGGFC
OrthoDBiEOG091G01BB
TreeFamiTF312838

Family and domain databases

CDDicd02608 P-type_ATPase_Na-K_like, 1 hit
Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR006068 ATPase_P-typ_cation-transptr_C
IPR004014 ATPase_P-typ_cation-transptr_N
IPR023299 ATPase_P-typ_cyto_dom_N
IPR018303 ATPase_P-typ_P_site
IPR023298 ATPase_P-typ_TM_dom_sf
IPR008250 ATPase_P-typ_transduc_dom_A_sf
IPR036412 HAD-like_sf
IPR023214 HAD_sf
IPR005775 P-type_ATPase_IIC
IPR001757 P_typ_ATPase
PfamiView protein in Pfam
PF00689 Cation_ATPase_C, 1 hit
PF00690 Cation_ATPase_N, 1 hit
SMARTiView protein in SMART
SM00831 Cation_ATPase_N, 1 hit
SUPFAMiSSF56784 SSF56784, 2 hits
SSF81653 SSF81653, 1 hit
SSF81660 SSF81660, 1 hit
SSF81665 SSF81665, 3 hits
TIGRFAMsiTIGR01106 ATPase-IIC_X-K, 1 hit
TIGR01494 ATPase_P-type, 2 hits
PROSITEiView protein in PROSITE
PS00154 ATPASE_E1_E2, 1 hit

Sequencei

Sequence statusi: Complete.

G3W5F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IEKATGREYS PAATTTENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG
60 70 80 90 100
RKYQVDLSKG LTNQRAQDIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI
110 120 130 140 150
LLWIGALLCF LAYGIQAAME DEPSNDNLYL GVVLAAVVIV TGCFSYYQEA
160 170 180 190 200
KSSKIMDSFK NMVPQQALVV REGEKMQINA EEVVVGDLVE VKGGDRVPAD
210 220 230 240 250
LRIISSHGCK VDNSSLTGES EPQTRSPEFT HENPLETRNI CFFSTNCVEG
260 270 280 290 300
TARGIVIATG DRTVMGRIAT LASGLEVGRT PIAMEIEHFI QLITGVAVFL
310 320 330 340 350
GVSFFVLSLI LGYSWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA
360 370 380 390 400
RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT
410 420 430 440 450
TEDQSDCHQP GATFDKRSPT WTALSRIAGL CNRAVFKAGQ ENISVSKRDT
460 470 480 490 500
AGDASESALL KCIELSCGSV RKMRERNPKV AEIPFNSTNK YQLSIHERED
510 520 530 540 550
SPQSHVLVMK GAPERILDRC SSILVQGKEI PLDKEMQDAF QNAYMELGGL
560 570 580 590 600
GERVLGFCHL NLPAAKFPRG FKFDTDELNF PTEKLCFVGL MSMIDPPRAA
610 620 630 640 650
VPDAVGKCRS AGIKVIMVTG DHPITAKAIA KGVGIISEGN ETVEDIAARL
660 670 680 690 700
NIPVSQVNPR EAKACVVHGS DLKDMTSEQL DEILKNHTEI VFARTSPQQK
710 720 730 740 750
LIIVEGCQRQ GAIVAVTGDG VNDSPALKKA DIGIAMGISG SDVSKQAADM
760 770 780 790 800
ILLDDNFASI VTGVEEGRLI FDNLKKSIAY TLTSNIPEIT PFLLFIIANI
810 820 830 840 850
PLPLGTVTIL CIDLGTDMVP AISLAYEAAE SDIMKRQPRN PQTDKLVNER
860 870 880 890 900
LISMAYGQIG MIQALGGFFT YFVILAENGF LPSRLLGIRL DWDDRSKNDL
910 920 930 940 950
EDSYGQEWTY EQRKVVEFTC HTAFFASIVV VQWADLIICK TRRNSVFQQG
960 970 980 990 1000
MKNKILIFGL LEETALAAFL SYCPGMGLAL RMYPLKVTWW FCAFPYSLLI
1010 1020
FIYDEVRKLI LRRYPGGWVE KETYY
Length:1,025
Mass (Da):112,928
Last modified:November 16, 2011 - v1
Checksum:iC9FCA0ED4B252F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01160655 Genomic DNA No translation available.
AEFK01160656 Genomic DNA No translation available.
AEFK01160657 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSSHAT00000010750; ENSSHAP00000010656; ENSSHAG00000009196

Similar proteinsi

Entry informationi

Entry nameiG3W5F1_SARHA
AccessioniPrimary (citable) accession number: G3W5F1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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