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Protein

Sodium/potassium-transporting ATPase subunit alpha

Gene

ATP1A2

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotation
Biological processIon transport, Potassium transportUniRule annotation, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotation, Nucleotide-binding, Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alphaUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:ATP1A2Imported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
Proteomesi
  • UP000007648 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei94 – 116HelicalUniRule annotationAdd BLAST23
Transmembranei128 – 147HelicalUniRule annotationAdd BLAST20
Transmembranei289 – 313HelicalUniRule annotationAdd BLAST25
Transmembranei319 – 342HelicalUniRule annotationAdd BLAST24
Transmembranei855 – 876HelicalUniRule annotationAdd BLAST22
Transmembranei955 – 981HelicalUniRule annotationAdd BLAST27
Transmembranei987 – 1003HelicalUniRule annotationAdd BLAST17

Keywords - Cellular componenti

Membrane

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000010656.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 114Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0203. Eukaryota.
COG0474. LUCA.
GeneTreeiENSGT00890000139334.
InParanoidiG3W5F1.
OMAiCVVAFIP.
OrthoDBiEOG091G01BB.
TreeFamiTF312838.

Family and domain databases

CDDicd02608. P-type_ATPase_Na-K_like. 1 hit.
Gene3Di3.40.1110.10. 1 hit.
InterProiView protein in InterPro
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_dom_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom_sf.
IPR008250. ATPase_P-typ_transduc_dom_A_sf.
IPR036412. HAD-like_sf.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

G3W5F1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IEKATGREYS PAATTTENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG
60 70 80 90 100
RKYQVDLSKG LTNQRAQDIL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI
110 120 130 140 150
LLWIGALLCF LAYGIQAAME DEPSNDNLYL GVVLAAVVIV TGCFSYYQEA
160 170 180 190 200
KSSKIMDSFK NMVPQQALVV REGEKMQINA EEVVVGDLVE VKGGDRVPAD
210 220 230 240 250
LRIISSHGCK VDNSSLTGES EPQTRSPEFT HENPLETRNI CFFSTNCVEG
260 270 280 290 300
TARGIVIATG DRTVMGRIAT LASGLEVGRT PIAMEIEHFI QLITGVAVFL
310 320 330 340 350
GVSFFVLSLI LGYSWLEAVI FLIGIIVANV PEGLLATVTV CLTLTAKRMA
360 370 380 390 400
RKNCLVKNLE AVETLGSTST ICSDKTGTLT QNRMTVAHMW FDNQIHEADT
410 420 430 440 450
TEDQSDCHQP GATFDKRSPT WTALSRIAGL CNRAVFKAGQ ENISVSKRDT
460 470 480 490 500
AGDASESALL KCIELSCGSV RKMRERNPKV AEIPFNSTNK YQLSIHERED
510 520 530 540 550
SPQSHVLVMK GAPERILDRC SSILVQGKEI PLDKEMQDAF QNAYMELGGL
560 570 580 590 600
GERVLGFCHL NLPAAKFPRG FKFDTDELNF PTEKLCFVGL MSMIDPPRAA
610 620 630 640 650
VPDAVGKCRS AGIKVIMVTG DHPITAKAIA KGVGIISEGN ETVEDIAARL
660 670 680 690 700
NIPVSQVNPR EAKACVVHGS DLKDMTSEQL DEILKNHTEI VFARTSPQQK
710 720 730 740 750
LIIVEGCQRQ GAIVAVTGDG VNDSPALKKA DIGIAMGISG SDVSKQAADM
760 770 780 790 800
ILLDDNFASI VTGVEEGRLI FDNLKKSIAY TLTSNIPEIT PFLLFIIANI
810 820 830 840 850
PLPLGTVTIL CIDLGTDMVP AISLAYEAAE SDIMKRQPRN PQTDKLVNER
860 870 880 890 900
LISMAYGQIG MIQALGGFFT YFVILAENGF LPSRLLGIRL DWDDRSKNDL
910 920 930 940 950
EDSYGQEWTY EQRKVVEFTC HTAFFASIVV VQWADLIICK TRRNSVFQQG
960 970 980 990 1000
MKNKILIFGL LEETALAAFL SYCPGMGLAL RMYPLKVTWW FCAFPYSLLI
1010 1020
FIYDEVRKLI LRRYPGGWVE KETYY
Length:1,025
Mass (Da):112,928
Last modified:November 16, 2011 - v1
Checksum:iC9FCA0ED4B252F62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01160655 Genomic DNA. No translation available.
AEFK01160656 Genomic DNA. No translation available.
AEFK01160657 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSSHAT00000010750; ENSSHAP00000010656; ENSSHAG00000009196.

Similar proteinsi

Entry informationi

Entry nameiG3W5F1_SARHA
AccessioniPrimary (citable) accession number: G3W5F1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 22, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported