G3W586 (G3W586_SARHA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Kynureninase PIRNR PIRNR038800
EC=3.7.1.3 PIRNR PIRNR038800

Gene names

Name:

KYNU Ensembl ENSSHAP00000010591

Organism

Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius) [Reference proteome] Ensembl ENSSHAP00000010591

Taxonomic identifier

9305 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Metatheria › Dasyuromorphia › Dasyuridae › Sarcophilus

Protein attributes

Sequence length	464 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively By similarity. PIRNR PIRNR038800
Catalytic activity	L-3-hydroxykynurenine + H2O = 3-hydroxyanthranilate + L-alanine. PIRNR PIRNR038800 L-kynurenine + H2O = anthranilate + L-alanine. PIRNR PIRNR038800
Cofactor	Pyridoxal phosphate By similarity. PIRNR PIRNR038800
Pathway	Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. PIRNR PIRNR038800 Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. PIRNR PIRNR038800
Subunit structure	Homodimer By similarity. PIRNR PIRNR038800
Subcellular location	Cytoplasm By similarity PIRNR PIRNR038800.
Sequence similarities	Belongs to the kynureninase family. PIRNR PIRNR038800
Caution	The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSSHAP00000010591

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis PIRNR PIRNR038800
Cellular component	Cytoplasm PIRNR PIRNR038800
Ligand	Pyridoxal phosphate PIRNR PIRNR038800
Molecular function	Hydrolase PIRNR PIRNR038800
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	L-kynurenine catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway NAD biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway tryptophan catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	kynureninase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G3W586 [UniParc]. Last modified November 16, 2011. Version 1. Checksum: 74E4F779A20A9678	FASTA	464	52,487
	10 20 30 40 50 60 MNSTSHELPV RTLECIASQL GCNLTDEKLA LYLDEQDELK HFQEYFHIPK MKDLPLIDLS 70 80 90 100 110 120 LVNKDENCIY LLGNSLGLQP RKVKTYLEEE MEKWAKIGSY GHEIGKRPWI TGDECIVHHM 130 140 150 160 170 180 NNIVGAHKDE IALMNGLTVN LHLLLLSFFK PTPTRFKILL EAKAFPSDHY AIESQLQLRG 190 200 210 220 230 240 LDVEKSMLMI KPRQGEDTLR MEDIFEVIEK EGDSIAVILF SGVQFYTGQL FDIPAITKAG 250 260 270 280 290 300 QAKGCFVGFD LAHAVGNVEL YLHDWGVDFA CWCSYKYLNS GAGALAGAFI HEKHAHTMKP 310 320 330 340 350 360 ALTGWFGHKL ESRFTMDNKL DLIPGVNGYR LSNPPILLVC ALEASLEIFS QTTMETLRKK 370 380 390 400 410 420 SILLTGYMEY LIKHYYSKDK TAPNKPFVKI MTPSHIEHRG CQLTLTFSIP MKSVFQELEK 430 440 450 460 RGVVCDKREP SGIRVAPVPL YNSFHDVYKF INVLASAISA AKLK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genetic diversity and population structure of the endangered marsupial Sarcophilus harrisii (Tasmanian devil)." Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P., Tindall E.A. , Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M., Jones M.E., Schuster S.C. Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	Ensembl Submitted (SEP-2011) to UniProtKB Cited for: IDENTIFICATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AEFK01110395 Genomic DNA. No translation available. AEFK01110396 Genomic DNA. No translation available. AEFK01110397 Genomic DNA. No translation available. AEFK01110398 Genomic DNA. No translation available. AEFK01110399 Genomic DNA. No translation available. AEFK01110400 Genomic DNA. No translation available.
RefSeq	XP_003763892.1. XM_003763844.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSSHAT00000010684; ENSSHAP00000010591; ENSSHAG00000009141.
GeneID	100918018.
KEGG	shr:100918018.
Organism-specific databases
CTD	8942.
Phylogenomic databases
GeneTree	ENSGT00390000008033.
KO	K01556.
OMA	MLTHVNY.
Enzyme and pathway databases
UniPathway	UPA00253; UER00329. UPA00334; UER00455.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
InterPro	IPR000192. Aminotrans_V/Cys_dSase. IPR010111. Kynureninase. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR14084. PTHR14084. 1 hit.
Pfam	PF00266. Aminotran_5. 1 hit. [Graphical view]
PIRSF	PIRSF038800. KYNU. 1 hit.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01814. kynureninase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

G3W586_SARHA

Accession

Primary (citable) accession number: G3W586

Entry history

Integrated into UniProtKB/TrEMBL:	November 16, 2011
Last sequence update:	November 16, 2011
Last modified:	March 6, 2013
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)