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Protein
Submitted name:

Erythropoietin receptor

Gene

EPOR

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei135Required for ligand bindingUniRule annotation1
Sitei451Required for STAT5/PTPN11/SOCS3 bindingUniRule annotation1
Sitei481Required for STAT1/STAT3 activationUniRule annotation1
Sitei510Required for CrkL bindingUniRule annotation1

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Submitted name:
Erythropoietin receptorImported
Gene namesi
Name:EPORImported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
Proteomesi
  • UP000007648 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei268 – 289HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Sequence analysisAdd BLAST36
ChainiPRO_500345847037 – 534Sequence analysisAdd BLAST498

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 82UniRule annotation
Disulfide bondi109 ↔ 125UniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotation

Interactioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei385Interaction with APS and STAT5, and activationUniRule annotation1
Sitei479Interaction with PTPN6UniRule annotation1

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000007486

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini165 – 262Fibronectin type-IIIInterPro annotationAdd BLAST98

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IFGH Eukaryota
ENOG4111PGS LUCA
GeneTreeiENSGT00890000139540
InParanoidiG3VWD1
OMAiVGSEHAQ
OrthoDBiEOG091G0AK8
TreeFamiTF336573

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR009167 Erythropoietin_rcpt
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR015152 Growth/epo_recpt_lig-bind
IPR013783 Ig-like_fold
IPR003528 Long_hematopoietin_rcpt_CS
PANTHERiPTHR23037:SF28 PTHR23037:SF28, 1 hit
PfamiView protein in Pfam
PF09067 EpoR_lig-bind, 1 hit
PF00041 fn3, 1 hit
PIRSFiPIRSF001959 EPO_receptor, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 1 hit
SUPFAMiSSF49265 SSF49265, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 1 hit
PS01352 HEMATOPO_REC_L_F1, 1 hit

Sequencei

Sequence statusi: Complete.

G3VWD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCSQARGARA MERPGPPHWP GIGSLCVLLS AGAAWATPAP SWELKPEPGL
60 70 80 90 100
EGPLYESKVT LLLAEEKEKP ICFTQRLEDL VCFWEETASP GPRNYSFFYH
110 120 130 140 150
LEEELWKPCV LKVVWTGRGT VRYTCPFPLS DASSFIPLEL KVTATPNGTE
160 170 180 190 200
LRRTIYINEV VFLDPPSGLT VQRTETPNQV ALHWLPPPMA QLTKDIHYEV
210 220 230 240 250
KYWEAAGTSE QRMDVREGRT GCVIANLRGH TRYTFAVRAK MAEPSYSGYW
260 270 280 290 300
SSWSQPVTVL IASELDPLIL GMSAILTVIL LLLVLVGLLS QRRFLKQMLW
310 320 330 340 350
PGVPSPEHGF QDLFTIHRGN FQLWLEESNA CLWWGPLSTY LEKPPARLEV
360 370 380 390 400
LSEHCRAAPA EPAREEEPLL GPEACWLAQG AKDDYLVLDT KLLPHSPAAG
410 420 430 440 450
PPGRGPLGLQ ALAGRAPEAQ GEPAGEAGAR SGALVPEPEQ EERASASNFE
460 470 480 490 500
YTVLDAGSQL LCPRVSLPAR PPGPPDLKYL YLVVSDSGIS ADYSSGASQG
510 520 530
TPGSSPEGPY TNLYENSLLQ PSPEPLPPSY VTCS
Length:534
Mass (Da):58,547
Last modified:November 16, 2011 - v1
Checksum:i94FE52ED233A8AEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01068443 Genomic DNA No translation available.
AEFK01068444 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSSHAT00000007548; ENSSHAP00000007486; ENSSHAG00000006505

Similar proteinsi

Entry informationi

Entry nameiG3VWD1_SARHA
AccessioniPrimary (citable) accession number: G3VWD1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 25, 2018
This is version 34 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health