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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 1

Gene

PCSK1

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS08.072

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 1Imported
Gene namesi
Name:PCSK1Imported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
Proteomesi
  • UP000007648 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000003329

Structurei

3D structure databases

ProteinModelPortaliG3VJH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini460 – 597P/Homo BInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3525 Eukaryota
COG1404 LUCA
COG4935 LUCA
GeneTreeiENSGT00750000117358
InParanoidiG3VJH4
KOiK01359
OMAiFEPRALK
OrthoDBiEOG091G05HI
TreeFamiTF314277

Family and domain databases

CDDicd04059 Peptidases_S8_Protein_converta, 1 hit
Gene3Di2.60.120.260, 1 hit
3.30.70.850, 1 hit
3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR008979 Galactose-bd-like_sf
IPR034182 Kexin/furin
IPR002884 P_dom
IPR000209 Peptidase_S8/S53_dom
IPR036852 Peptidase_S8/S53_dom_sf
IPR023827 Peptidase_S8_Asp-AS
IPR022398 Peptidase_S8_His-AS
IPR023828 Peptidase_S8_Ser-AS
IPR015500 Peptidase_S8_subtilisin-rel
IPR022005 Proho_convert
IPR032815 S8_pro-domain
IPR038466 S8_pro-domain_sf
PfamiView protein in Pfam
PF01483 P_proprotein, 1 hit
PF00082 Peptidase_S8, 1 hit
PF12177 Proho_convert, 1 hit
PF16470 S8_pro-domain, 1 hit
PRINTSiPR00723 SUBTILISIN
SUPFAMiSSF49785 SSF49785, 1 hit
SSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51829 P_HOMO_B, 1 hit
PS00136 SUBTILASE_ASP, 1 hit
PS00137 SUBTILASE_HIS, 1 hit
PS00138 SUBTILASE_SER, 1 hit

Sequencei

Sequence statusi: Complete.

G3VJH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRYWSLQY IAFALYFCWC AMYSGRAEKQ FVNEWAAEIP GGLNSAREIA
60 70 80 90 100
EELGYDLLGQ IGSLENHYLF RHKSHPRRSR RSAIHITKRL SDDDRVTWAE
110 120 130 140 150
QQYGKERNKR SILRDSAEDL FNDPMWNQQW YLQDTRMTPV LPKLDLHVIP
160 170 180 190 200
VWQKGITGKG VVITVLDDGL EWNHTDIYAN YDPEASYDFN DNDRDPFPRY
210 220 230 240 250
DPTNENKHGT RCAGEIAMQA NNQKCGVGVA YNARVGGIRM LDGIVTDAIE
260 270 280 290 300
ASSIGFNPNH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GIKQGRQGKG
310 320 330 340 350
SIFVWASGNG GRQGDDCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST
360 370 380 390 400
LATAYSSGDY TDQRITSADL HDDCTETHTG TSASAPLAAG IFALALEVNP
410 420 430 440 450
QLTWRDMQHL VVWTSEYDPL AINPGWKKNG AGLMVNSRFG FGLLNAKALV
460 470 480 490 500
DLADPKTWRG VPEKKECIVK DNNFEPKSLK ADGVVTIEIP TKACEGQENS
510 520 530 540 550
IKSLEHVQFE ATIEYSRRGD LHVTLTSAAG TSTVLLAERE RDTSPNGFKN
560 570 580 590 600
WDFMSVHTWG ENPVGTWALR ITDMSGRMEN EGRIVNWKLI LHGTSTQPEH
610 620 630 640 650
MKQPRVYTSY NAVQNDRRGV EKMDDSIEDE ATLESLHESP QPSKSSTTPN
660 670 680 690 700
ISGNDKLMEK TPSRAMLQLL QNAFSKQGAS NQTPKNHPDE KLKIPYEHFY
710 720 730 740 750
QALEKLNKPS QLRNAENSLY SDYVDLFYST KPYKHRDDRL LQALVDILKE

GN
Length:752
Mass (Da):84,535
Last modified:November 16, 2011 - v1
Checksum:iAAA0D852A15337BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01057912 Genomic DNA No translation available.
AEFK01057913 Genomic DNA No translation available.
RefSeqiXP_003759876.1, XM_003759828.1

Genome annotation databases

EnsembliENSSHAT00000003365; ENSSHAP00000003329; ENSSHAG00000002927
GeneIDi100925062
KEGGishr:100925062

Similar proteinsi

Entry informationi

Entry nameiG3VJH4_SARHA
AccessioniPrimary (citable) accession number: G3VJH4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health