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Protein
Submitted name:

Proprotein convertase subtilisin/kexin type 1

Gene

PCSK1

Organism
Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS08.072.

Names & Taxonomyi

Protein namesi
Submitted name:
Proprotein convertase subtilisin/kexin type 1Imported
Gene namesi
Name:PCSK1Imported
OrganismiSarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius)Imported
Taxonomic identifieri9305 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDasyuromorphiaDasyuridaeSarcophilus
Proteomesi
  • UP000007648 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

Protein-protein interaction databases

STRINGi9305.ENSSHAP00000003329.

Structurei

3D structure databases

ProteinModelPortaliG3VJH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 110S8_pro-domainInterPro annotationAdd BLAST77
Domaini158 – 442Peptidase S8InterPro annotationAdd BLAST285
Domaini504 – 591P_proproteinInterPro annotationAdd BLAST88
Domaini712 – 750Proho_convertInterPro annotationAdd BLAST39

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3525. Eukaryota.
COG1404. LUCA.
COG4935. LUCA.
GeneTreeiENSGT00750000117358.
InParanoidiG3VJH4.
KOiK01359.
OMAiFEPRALK.
OrthoDBiEOG091G05HI.
TreeFamiTF314277.

Family and domain databases

CDDicd04059. Peptidases_S8_Protein_converta. 1 hit.
Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiView protein in InterPro
IPR008979. Galactose-bd-like.
IPR034182. Kexin/furin.
IPR009020. Peptidase/Inhibitor_I9.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR022005. Proho_convert.
IPR002884. PrprotnconvertsP.
IPR032815. S8_pro-domain.
PfamiView protein in Pfam
PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
PF12177. Proho_convert. 1 hit.
PF16470. S8_pro-domain. 1 hit.
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiView protein in PROSITE
PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

G3VJH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVRYWSLQY IAFALYFCWC AMYSGRAEKQ FVNEWAAEIP GGLNSAREIA
60 70 80 90 100
EELGYDLLGQ IGSLENHYLF RHKSHPRRSR RSAIHITKRL SDDDRVTWAE
110 120 130 140 150
QQYGKERNKR SILRDSAEDL FNDPMWNQQW YLQDTRMTPV LPKLDLHVIP
160 170 180 190 200
VWQKGITGKG VVITVLDDGL EWNHTDIYAN YDPEASYDFN DNDRDPFPRY
210 220 230 240 250
DPTNENKHGT RCAGEIAMQA NNQKCGVGVA YNARVGGIRM LDGIVTDAIE
260 270 280 290 300
ASSIGFNPNH VDIYSASWGP NDDGKTVEGP GRLAQKAFEY GIKQGRQGKG
310 320 330 340 350
SIFVWASGNG GRQGDDCDCD GYTDSIYTIS ISSASQQGLS PWYAEKCSST
360 370 380 390 400
LATAYSSGDY TDQRITSADL HDDCTETHTG TSASAPLAAG IFALALEVNP
410 420 430 440 450
QLTWRDMQHL VVWTSEYDPL AINPGWKKNG AGLMVNSRFG FGLLNAKALV
460 470 480 490 500
DLADPKTWRG VPEKKECIVK DNNFEPKSLK ADGVVTIEIP TKACEGQENS
510 520 530 540 550
IKSLEHVQFE ATIEYSRRGD LHVTLTSAAG TSTVLLAERE RDTSPNGFKN
560 570 580 590 600
WDFMSVHTWG ENPVGTWALR ITDMSGRMEN EGRIVNWKLI LHGTSTQPEH
610 620 630 640 650
MKQPRVYTSY NAVQNDRRGV EKMDDSIEDE ATLESLHESP QPSKSSTTPN
660 670 680 690 700
ISGNDKLMEK TPSRAMLQLL QNAFSKQGAS NQTPKNHPDE KLKIPYEHFY
710 720 730 740 750
QALEKLNKPS QLRNAENSLY SDYVDLFYST KPYKHRDDRL LQALVDILKE

GN
Length:752
Mass (Da):84,535
Last modified:November 16, 2011 - v1
Checksum:iAAA0D852A15337BE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AEFK01057912 Genomic DNA. No translation available.
AEFK01057913 Genomic DNA. No translation available.
RefSeqiXP_003759876.1. XM_003759828.1.

Genome annotation databases

EnsembliENSSHAT00000003365; ENSSHAP00000003329; ENSSHAG00000002927.
GeneIDi100925062.
KEGGishr:100925062.

Similar proteinsi

Entry informationi

Entry nameiG3VJH4_SARHA
AccessioniPrimary (citable) accession number: G3VJH4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: August 30, 2017
This is version 38 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported