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Protein

Phosphoinositide phospholipase C

Gene

Plce1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotation, HydrolaseUniRule annotationSAAS annotation, TransducerSAAS annotation
Biological processLipid degradationUniRule annotationSAAS annotation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-RNO-1855204. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase CUniRule annotation (EC:3.1.4.11UniRule annotation)
Gene namesi
Name:Plce1Imported
ORF Names:rCG_48328Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi69424. Plce1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000014276.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini528 – 781Ras-GEFInterPro annotationAdd BLAST254
Domaini1373 – 1521PI-PLC X-boxInterPro annotationAdd BLAST149
Domaini1734 – 1824PI-PLC Y-boxInterPro annotationAdd BLAST91
Domaini1839 – 1923C2InterPro annotationAdd BLAST85
Domaini2114 – 2217Ras-associatingInterPro annotationAdd BLAST104

Phylogenomic databases

eggNOGiKOG0169. Eukaryota.
ENOG410XPSW. LUCA.
GeneTreeiENSGT00730000110782.
OMAiKVLKMWQ.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 1 hit.
InterProiView protein in InterPro
IPR000008. C2_dom.
IPR035892. C2_domain_sf.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR028398. PLC-epsilon1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000159. RA_dom.
IPR023578. Ras_GEF_dom_sf.
IPR001895. RASGEF_cat_dom.
IPR036964. RASGEF_cat_dom_sf.
IPR029071. Ubiquitin-like_domsf.
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF6. PTHR10336:SF6. 1 hit.
PfamiView protein in Pfam
PF00168. C2. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiView protein in SMART
SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
SUPFAMiSSF47473. SSF47473. 2 hits.
SSF48366. SSF48366. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 3 hits.
SSF54236. SSF54236. 2 hits.
PROSITEiView protein in PROSITE
PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V9X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEEMAASF LIPVPQRKVA SAQSVAEERG EKVSEAGIPK TRAGRQGGLT
60 70 80 90 100
PRTISQRNEP EEESPRTDFS QVFSIARGEL DSDENHNERC WEENVPGSTK
110 120 130 140 150
NHAVNCNSLL QSHQHALPPS QLCEVCDSVT EEHLCLQPGI PSPLERKVFP
160 170 180 190 200
GIELEMEDSP MDVSPLGNQP GIMESSGPHS DRNMAVFHFH YAGDRTMPGA
210 220 230 240 250
FHTLSEKFIL DDCANCVTLP GGQQNKNYMA YTCKLVELTR TCGSKNGQLK
260 270 280 290 300
CDHCTSLRDE YLCFESSCRK AEALSSGGGF CEDGFTHGPS AKTFLNPLEE
310 320 330 340 350
FSDNCEDVDD IFKGKKERST LLVRRFCKND REVKKSVYTG TRAIVRTLPS
360 370 380 390 400
GHIGLAAWSY VDQKKAGLMW PCGNGMRPLS TVDVRQSGRQ RLSEAQWCLI
410 420 430 440 450
YSAVRREETE DTVGSLLHCS TQLPTPDTAH GRIGDGPCLK QCVRDSECEY
460 470 480 490 500
RATLQRTSIA QYITGSLLEA TTSLGARSSL LSSFGGSTGR IMLKERQPGT
510 520 530 540 550
SMANSSPVPS SSAGISKELI DLQPLIQFPE EVASILTEQE QNIYRRVLPM
560 570 580 590 600
DYLCFLTRDL SSPECQRSLP RLKACISESI LMSQSGEHNA LEDLVMRFNE
610 620 630 640 650
VSSWVTWLIL TAGSMEEKRE VFSYLVHVAK CCWNMGNYNA VMEFLAGLRS
660 670 680 690 700
RKVLKMWQFM DQSDIETMRS LKDAMAQHES SVEYKKVVTR ALHIPGCKVV
710 720 730 740 750
PFCGVFLKEL CEVLDGASGL LKLCPRYSSQ EEALEFVADY SGQDNFLQRV
760 770 780 790 800
GQNGLKNPEK ELTVNSIFQI IRSCSRSLET EDEESASEGS GSRKNSLKDK
810 820 830 840 850
TRWQFIIGDL LDSDNDIFEK SKECDPHGSE ESQKAFDHGT ELIPWYVLSI
860 870 880 890 900
QADVHQFLLQ GATVIHYDQD THLSARCFLQ LQPDNSTLTW MKPPTASPAG
910 920 930 940 950
ARLKLGVLSN VAEPGKFPSL GNAGVSGLVE GILDLFSVKA VYMGHPGIDI
960 970 980 990 1000
HTVCVQNKLS SMLLSETGVT LLYGLQTTDN RLLHFVAPKH TAKMLFSGLL
1010 1020 1030 1040 1050
ELTTAVRKIR KFPDQRQQWL RKQYVSFYQE DGRYEGPTLA HAVELFGGRR
1060 1070 1080 1090 1100
WSTRNPSPGM SAKNAEKPNM QRNNTLGIST TKKKKKMLMR GESGEVTDDE
1110 1120 1130 1140 1150
MATRKAKMYR ECRSRSGSDP QEANEQEDSE ANVITNPPNP LHSRRAYSLT
1160 1170 1180 1190 1200
TAGSPNLATG MSSPISAWSS SSWHGRIKGG MKGFQSFMVS DSNMSFIEFV
1210 1220 1230 1240 1250
ELFKSFSIRS RKDLKDIFDI YSVPCNRSAS ESAPLYTNLT IEENTNDLQP
1260 1270 1280 1290 1300
DLDLLTRNVS DLGLFMKSKQ QLSDNQRQIS DAIAAASIVT NGTGIESTSL
1310 1320 1330 1340 1350
GIFGVGILQL NDFLVNCQGE HCTYDEILSI IQKFEPNISM CHQGLLSFEG
1360 1370 1380 1390 1400
FARFLMDKDN FASKNDESRE NKKDLQLPLS YYYIESSHNT YLTGHQLKGE
1410 1420 1430 1440 1450
SSVELYSQVL LQGCRSIELD CWDGDDGMPI IYHGHTLTTK IPFKEVVEAI
1460 1470 1480 1490 1500
DRSAFITSDL PIIISIENHC SLPQQRKMAE IFKSVFGEKL VAKFLFETDF
1510 1520 1530 1540 1550
SDDPMLPSPD QLRRKVLLKN KKLKAHQTPV DILKQKAHQL ASMQTQAFTG
1560 1570 1580 1590 1600
GNANPPPASN EEEEDEEDEY DYDYESLSDD NILEDRPENK SCADKLQFEY
1610 1620 1630 1640 1650
NEEVPKRIKK ADNSSGNKGK VYDMELGEEF YLPQNKKESR QIAPELSDLV
1660 1670 1680 1690 1700
IYCQAVKFPG LSTLNSSGSG RGKERKSRKS IFGNNPGRMS PGETASFNRT
1710 1720 1730 1740 1750
SGKSSCEGIR QIWEEPPLSP NTSLSAIIRT PKCYHISSLN ENAAKRLCRR
1760 1770 1780 1790 1800
YSQKLIQHTA CQLLRTYPAA TRIDSSNPNP LMFWLHGIQL VALNYQTDDL
1810 1820 1830 1840 1850
PLHLNAAMFE ANGGCGYVLK PPVLWDKSCP MYQKFSPLER DLDAMDPATY
1860 1870 1880 1890 1900
SLTIISGQNV CPSNSTGSPC IEVDVLGMPL DSCHFRTKPI HRNTLNPMWN
1910 1920 1930 1940 1950
EQFLFRVHFE DLVFLRFAVV ENNSSAITAQ RIIPLKALKR GYRHLQLRNL
1960 1970 1980 1990 2000
HNEILEISSL FINSRRMEDN PSGSTRPASL MFNTEERKCS QTHKVTVHGV
2010 2020 2030 2040 2050
PGPEPFAVFT INEGTKAKQL LQQILAVDQD TKLTAADYFL MEEKHFISKE
2060 2070 2080 2090 2100
KNECRKQPFQ RAVGPEEDIV QILNSWFPEE GYVGRIVLKP QQETLEEKNI
2110 2120 2130 2140 2150
VHDDREVILS SEEESFFVQV HDVSPEQPRT VIKAPRVSTA QDVIQQTLCK
2160 2170 2180 2190 2200
AKYSYSILNN PNPCDYVLLE EVMKDAPNKK SSTPKSSQRI LLDQECVFQA
2210 2220 2230 2240 2250
QSKWKGAGKF ILKLKEQVQA SREDKRRGIS FASELKKLTK STKQTRGLTS
2260 2270 2280
PPQLVASESV QSKEEKPMGA LASGDTAGYQ S
Length:2,281
Mass (Da):255,363
Last modified:November 16, 2011 - v1
Checksum:i750CF769E20A2CEF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC117848 Genomic DNA. No translation available.
AC122568 Genomic DNA. No translation available.
AC132689 Genomic DNA. No translation available.
CH473953 Genomic DNA. Translation: EDM13222.1.
UniGeneiRn.64650.

Genome annotation databases

EnsembliENSRNOT00000067149; ENSRNOP00000062667; ENSRNOG00000014276.
ENSRNOT00000079219; ENSRNOP00000072165; ENSRNOG00000014276.

Similar proteinsi

Entry informationi

Entry nameiG3V9X9_RAT
AccessioniPrimary (citable) accession number: G3V9X9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 22, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported