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G3V9S4

- G3V9S4_RAT

UniProt

G3V9S4 - G3V9S4_RAT

Protein
Submitted name:

Dopamine beta hydroxylase

Gene

Dbh

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 20 (01 Oct 2014)
      Sequence version 1 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen Source: InterPro

    GO - Biological processi

    1. behavioral response to ethanol Source: Ensembl
    2. blood vessel remodeling Source: Ensembl
    3. cytokine production Source: Ensembl
    4. dopamine catabolic process Source: Ensembl
    5. fear response Source: Ensembl
    6. glucose homeostasis Source: Ensembl
    7. homoiothermy Source: Ensembl
    8. leukocyte mediated immunity Source: Ensembl
    9. leukocyte migration Source: Ensembl
    10. locomotory behavior Source: Ensembl
    11. maternal behavior Source: Ensembl
    12. memory Source: Ensembl
    13. positive regulation of vasoconstriction Source: Ensembl
    14. regulation of cell proliferation Source: Ensembl
    15. regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    16. response to amphetamine Source: Ensembl
    17. response to pain Source: Ensembl
    18. visual learning Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Dopamine beta hydroxylaseImported
    Submitted name:
    Dopamine beta-hydroxylaseImported
    Gene namesi
    Name:DbhImported
    ORF Names:rCG_45701Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 3

    Organism-specific databases

    RGDi2489. Dbh.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00530000063085.
    OMAiSYFGDAW.
    OrthoDBiEOG78WKR4.
    TreeFamiTF320698.

    Family and domain databases

    Gene3Di2.60.120.230. 1 hit.
    2.60.120.310. 1 hit.
    InterProiIPR014784. Cu2_ascorb_mOase-like_C.
    IPR020611. Cu2_ascorb_mOase_CS-1.
    IPR000323. Cu2_ascorb_mOase_N.
    IPR000945. DBH-rel.
    IPR005018. DOMON_domain.
    IPR008977. PHM/PNGase_F_dom.
    IPR028460. Tbh/DBH.
    [Graphical view]
    PANTHERiPTHR10157. PTHR10157. 1 hit.
    PTHR10157:SF4. PTHR10157:SF4. 1 hit.
    PfamiPF01082. Cu2_monooxygen. 1 hit.
    PF03351. DOMON. 1 hit.
    [Graphical view]
    PRINTSiPR00767. DBMONOXGNASE.
    SMARTiSM00664. DoH. 1 hit.
    [Graphical view]
    SUPFAMiSSF49742. SSF49742. 2 hits.
    PROSITEiPS00084. CU2_MONOOXYGENASE_1. 1 hit.
    PS50836. DOMON. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    G3V9S4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPHLSHQPC WSLPSPSVRE AASMYGTAVA IFLVILVAAL QGSEPPESPF    50
    PYHIPLDPEG TLELSWNVSY DQEIIHFQLQ VQGPRAGVLF GMSDRGEMEN 100
    ADLVMLWTDG DRTYFADAWS DQKGQIHLDT HQDYQLLQAQ RVSNSLSLLF 150
    KRPFVTCDPK DYVIEDDTVH LVYGILEEPF QSLEAINTSG LHTGLQQVQL 200
    LKPEVSTPAM PADVQTMDIR APDVLIPSTE TTYWCYITEL PLHFPRHHII 250
    MYEAIVTEGN EALVHHMEVF QCTNESEAFP MFNGPCDSKM KPDRLNYCRH 300
    VLAAWALGAK AFYYPEEAGV PFGGSGSSRF LRLEVHYHNP RNIQGRRDSS 350
    GIRLHYTASL RPNEAGIMEL GLVYTPLMAI PPQETTFVLT GYCTDRCTQM 400
    ALPKSGIRIF ASQLHTHLTG RKVITVLARD GQQREVVNRD NHYSPHFQEI 450
    RMLKNAVTVH QGDVLITSCT YNTENRTMAT VGGFGILEEM CVNYVHYYPK 500
    TELELCKSAV DDGFLQKYFH IVNRFGNEEV CTCPQASVPQ QFASVPWNSF 550
    NRDMLKALYN YAPISVHCNK TSAVRFPGNW NLQPLPKITS AVEEPDPRCP 600
    IRQTRGPAGP FVVITTEADT E 621
    Length:621
    Mass (Da):69,996
    Last modified:November 16, 2011 - v1
    Checksum:iAC8213A9291902C6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06022026 Genomic DNA. No translation available.
    AABR06022027 Genomic DNA. No translation available.
    AABR06022028 Genomic DNA. No translation available.
    CH474001 Genomic DNA. Translation: EDL93440.1.
    UniGeneiRn.87166.

    Genome annotation databases

    EnsembliENSRNOT00000061201; ENSRNOP00000057915; ENSRNOG00000006641.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06022026 Genomic DNA. No translation available.
    AABR06022027 Genomic DNA. No translation available.
    AABR06022028 Genomic DNA. No translation available.
    CH474001 Genomic DNA. Translation: EDL93440.1 .
    UniGenei Rn.87166.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000061201 ; ENSRNOP00000057915 ; ENSRNOG00000006641 .

    Organism-specific databases

    RGDi 2489. Dbh.

    Phylogenomic databases

    GeneTreei ENSGT00530000063085.
    OMAi SYFGDAW.
    OrthoDBi EOG78WKR4.
    TreeFami TF320698.

    Miscellaneous databases

    NextBioi 35584407.
    PROi G3V9S4.

    Family and domain databases

    Gene3Di 2.60.120.230. 1 hit.
    2.60.120.310. 1 hit.
    InterProi IPR014784. Cu2_ascorb_mOase-like_C.
    IPR020611. Cu2_ascorb_mOase_CS-1.
    IPR000323. Cu2_ascorb_mOase_N.
    IPR000945. DBH-rel.
    IPR005018. DOMON_domain.
    IPR008977. PHM/PNGase_F_dom.
    IPR028460. Tbh/DBH.
    [Graphical view ]
    PANTHERi PTHR10157. PTHR10157. 1 hit.
    PTHR10157:SF4. PTHR10157:SF4. 1 hit.
    Pfami PF01082. Cu2_monooxygen. 1 hit.
    PF03351. DOMON. 1 hit.
    [Graphical view ]
    PRINTSi PR00767. DBMONOXGNASE.
    SMARTi SM00664. DoH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49742. SSF49742. 2 hits.
    PROSITEi PS00084. CU2_MONOOXYGENASE_1. 1 hit.
    PS50836. DOMON. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    2. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    3. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    4. Ensembl
      Submitted (SEP-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiG3V9S4_RAT
    AccessioniPrimary (citable) accession number: G3V9S4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 16, 2011
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3