G3V9S4 (G3V9S4_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Dopamine beta hydroxylase EMBL EDL93440.1

Submitted name:
Dopamine beta-hydroxylase Ensembl ENSRNOP00000057915

Gene names

Name:	Dbh Ensembl ENSRNOP00000057915 EMBL EDL93440.1
ORF Names:	rCG_45701 EMBL EDL93440.1

Organism

Rattus norvegicus (Rat) [Reference proteome] Ensembl ENSRNOP00000057915

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	621 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	behavioral response to ethanol Inferred from electronic annotation. Source: Compara blood vessel remodeling Inferred from electronic annotation. Source: Compara cytokine production Inferred from electronic annotation. Source: Compara dopamine catabolic process Inferred from electronic annotation. Source: Compara fear response Inferred from electronic annotation. Source: Compara glucose homeostasis Inferred from electronic annotation. Source: Compara homoiothermy Inferred from electronic annotation. Source: Compara leukocyte mediated immunity Inferred from electronic annotation. Source: Compara leukocyte migration Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara maternal behavior Inferred from electronic annotation. Source: Compara memory Inferred from electronic annotation. Source: Compara norepinephrine biosynthetic process Inferred from electronic annotation. Source: Compara positive regulation of vasoconstriction Inferred from electronic annotation. Source: Compara regulation of apoptotic process Inferred from electronic annotation. Source: Compara regulation of cell proliferation Inferred from electronic annotation. Source: Compara response to amphetamine Inferred from electronic annotation. Source: Compara response to pain Inferred from electronic annotation. Source: Compara visual learning Inferred from electronic annotation. Source: Compara
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro dopamine beta-monooxygenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	G3V9S4 [UniParc]. Last modified November 16, 2011. Version 1. Checksum: AC8213A9291902C6	FASTA	621	69,996
	10 20 30 40 50 60 MQPHLSHQPC WSLPSPSVRE AASMYGTAVA IFLVILVAAL QGSEPPESPF PYHIPLDPEG 70 80 90 100 110 120 TLELSWNVSY DQEIIHFQLQ VQGPRAGVLF GMSDRGEMEN ADLVMLWTDG DRTYFADAWS 130 140 150 160 170 180 DQKGQIHLDT HQDYQLLQAQ RVSNSLSLLF KRPFVTCDPK DYVIEDDTVH LVYGILEEPF 190 200 210 220 230 240 QSLEAINTSG LHTGLQQVQL LKPEVSTPAM PADVQTMDIR APDVLIPSTE TTYWCYITEL 250 260 270 280 290 300 PLHFPRHHII MYEAIVTEGN EALVHHMEVF QCTNESEAFP MFNGPCDSKM KPDRLNYCRH 310 320 330 340 350 360 VLAAWALGAK AFYYPEEAGV PFGGSGSSRF LRLEVHYHNP RNIQGRRDSS GIRLHYTASL 370 380 390 400 410 420 RPNEAGIMEL GLVYTPLMAI PPQETTFVLT GYCTDRCTQM ALPKSGIRIF ASQLHTHLTG 430 440 450 460 470 480 RKVITVLARD GQQREVVNRD NHYSPHFQEI RMLKNAVTVH QGDVLITSCT YNTENRTMAT 490 500 510 520 530 540 VGGFGILEEM CVNYVHYYPK TELELCKSAV DDGFLQKYFH IVNRFGNEEV CTCPQASVPQ 550 560 570 580 590 600 QFASVPWNSF NRDMLKALYN YAPISVHCNK TSAVRFPGNW NLQPLPKITS AVEEPDPRCP 610 620 IRQTRGPAGP FVVITTEADT E

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the Brown Norway rat yields insights into mammalian evolution." Rat Genome Sequencing Project Consortium Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M. , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S. Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway Ensembl ENSRNOP00000057915.
[2]	"Gene and alternative splicing annotation with AIR." Florea L., Di Francesco V., Miller J., Turner R., Yao A., Harris M., Walenz B., Mobarry C., Merkulov G.V., Charlab R., Dew I., Deng Z., Istrail S., Li P., Sutton G. Genome Res. 15:54-66(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL93440.1.
[3]	Mural R.J., Li P.W., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S.H., Dew I., Evans C.A., Ferriera S., Flanigan M., Fosler C., Glodek A., Gu Z., Holt R.A., Jennings D., Kraft C.L., Lu F. , Nguyen T., Nusskern D.R., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Wang Z., Woodage T., Zheng X.H., Zhong F. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: BN EMBL EDL93440.1.
[4]	Ensembl Submitted (SEP-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Brown Norway Ensembl ENSRNOP00000057915.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AABR06022026 Genomic DNA. No translation available. AABR06022027 Genomic DNA. No translation available. AABR06022028 Genomic DNA. No translation available. CH474001 Genomic DNA. Translation: EDL93440.1.
UniGene	Rn.87166.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000061201; ENSRNOP00000057915; ENSRNOG00000006641.
Organism-specific databases
RGD	2489. Dbh.
Phylogenomic databases
GeneTree	ENSGT00530000063085.
OMA	GAKAFYY.
Family and domain databases
Gene3D	2.60.120.230. 1 hit. 2.60.120.310. 1 hit.
InterPro	IPR014784. Cu2_ascorb_mOase-like_C. IPR020611. Cu2_ascorb_mOase_CS-1. IPR000323. Cu2_ascorb_mOase_N. IPR005018. DOMON_domain. IPR000945. Dopamine_b_mOase. IPR008977. PHM/PNGase_F_dom. [Graphical view]
PANTHER	PTHR10157. PTHR10157. 1 hit.
Pfam	PF01082. Cu2_monooxygen. 1 hit. PF03351. DOMON. 1 hit. [Graphical view]
PRINTS	PR00767. DBMONOXGNASE.
SMART	SM00664. DoH. 1 hit. [Graphical view]
SUPFAM	SSF49742. PHM_PNGase_F. 2 hits.
PROSITE	PS00084. CU2_MONOOXYGENASE_1. 1 hit. PS50836. DOMON. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	35584407.

Entry information

Entry name

G3V9S4_RAT

Accession

Primary (citable) accession number: G3V9S4

Entry history

Integrated into UniProtKB/TrEMBL:	November 16, 2011
Last sequence update:	November 16, 2011
Last modified:	April 3, 2013
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)