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Protein
Submitted name:

Protein tyrosine phosphatase, non-receptor type 13

Gene

Ptpn13

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei2349SubstrateUniRule annotation1
Active sitei2379Phosphocysteine intermediateUniRule annotation1
Binding sitei2423SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-1660499. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Submitted name:
Protein tyrosine phosphatase, non-receptor type 13Imported
Submitted name:
RCG37921, isoform CRA_bImported
Gene namesi
Name:Ptpn13Imported
ORF Names:rCG_37921Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi1563360. Ptpn13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSRNOG00000002061.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000057876.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 190KINDInterPro annotationAdd BLAST188
Domaini565 – 865FERMInterPro annotationAdd BLAST301
Domaini1084 – 1170PDZInterPro annotationAdd BLAST87
Domaini1357 – 1442PDZInterPro annotationAdd BLAST86
Domaini1491 – 1579PDZInterPro annotationAdd BLAST89
Domaini1766 – 1847PDZInterPro annotationAdd BLAST82
Domaini1868 – 1944PDZInterPro annotationAdd BLAST77
Domaini2184 – 2438Tyrosine-protein phosphataseInterPro annotationAdd BLAST255
Domaini2360 – 2429TYR_PHOSPHATASE_2InterPro annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2379 – 2385Substrate bindingUniRule annotation7

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili464 – 491Sequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0792. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00900000140780.
KOiK02374.
OMAiGCYVHDV.
TreeFamiTF315388.

Family and domain databases

CDDicd14473. FERM_B-lobe. 1 hit.
Gene3Di1.20.80.10. 1 hit.
2.30.29.30. 1 hit.
3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR019749. Band_41_domain.
IPR014352. FERM/acyl-CoA-bd_prot_sf.
IPR035963. FERM_2.
IPR019748. FERM_central.
IPR000299. FERM_domain.
IPR018979. FERM_N.
IPR018980. FERM_PH-like_C.
IPR011019. KIND_dom.
IPR001478. PDZ.
IPR036034. PDZ_sf.
IPR011993. PH-like_dom_sf.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR012153. PTPN13.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR029071. Ubiquitin-like_domsf.
PANTHERiPTHR19134:SF197. PTHR19134:SF197. 2 hits.
PfamiView protein in Pfam
PF09380. FERM_C. 1 hit.
PF00373. FERM_M. 1 hit.
PF09379. FERM_N. 1 hit.
PF00595. PDZ. 5 hits.
PF00102. Y_phosphatase. 1 hit.
PIRSFiPIRSF000933. Tyr-Ptase_nr13. 1 hit.
PRINTSiPR00935. BAND41.
PR00700. PRTYPHPHTASE.
SMARTiView protein in SMART
SM00295. B41. 1 hit.
SM01196. FERM_C. 1 hit.
SM00750. KIND. 1 hit.
SM00228. PDZ. 5 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
SUPFAMiSSF47031. SSF47031. 1 hit.
SSF50156. SSF50156. 5 hits.
SSF50729. SSF50729. 1 hit.
SSF52799. SSF52799. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiView protein in PROSITE
PS50057. FERM_3. 1 hit.
PS51377. KIND. 1 hit.
PS50106. PDZ. 5 hits.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.

Sequencei

Sequence statusi: Complete.

G3V9S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHVSLAEALE VRGGPLQEEE IWAVLNQSAE SLQEVFRRVS IADPAALGFI
60 70 80 90 100
ISPWSLLLLP SGSVSFTDEN VCSQDLRAFT APEVLQSHSL TSLSDVEKVH
110 120 130 140 150
IYSLGMTLYW GADHEVPQSQ PIKLGDHLNS ILLGMCEDVL YARVSVRTVL
160 170 180 190 200
DACSAHIRNS NCAPSFSYVK QLVKLVLGNI SGTDPLSHSS EEKPDRSQAI
210 220 230 240 250
RDRLRGKGLP IGRSSTSDAL DTHKAPLSQQ TFLNKGLSKS MGFLSVRDTQ
260 270 280 290 300
EEEDYSKEIP SDNNSRHEDS EPFSSPYQFK TSSPHIDVLS KKKTWASSMD
310 320 330 340 350
LLCAADRDLS GEIGRYQHCD PETGTGRTSI TSRKKEGRYS DGSIALDVFG
360 370 380 390 400
PQKAEPVIHS RELPASSAVS SALDRIRERQ KKLQVLREAM NVEEPVRRYK
410 420 430 440 450
TYHSDLFSTS SESPSIISSD SDFRQVRKSE ASKRFESSSG LPGVDDTVQS
460 470 480 490 500
RPSRQYETSL EGSLINQEMM LRRQEEEMMQ LQARMALRQS RLSLYPGDTI
510 520 530 540 550
KTSMLDISRD PLREMALETA MTQRKLRNFF GPEFVKTTVE PFASLDLPRS
560 570 580 590 600
ILLQTKKGKS EEQRKKVNIM LLSGQRLELT CDTKTVCRDV FDMVVAHIGL
610 620 630 640 650
VEHHLFALAT LKENEYFFVD PDLKLTKVAP EGWKEEPKRK GKAAVDFTLF
660 670 680 690 700
FRIKFFMDDV SLIQHSLTCH QYYLQLRKDL LEERIHCDDE ASLLLASLAL
710 720 730 740 750
QAEYGDYQPE VHGLSYFRLE HYLPARVMEK LDMSYIKEEL PKLHNTYAGA
760 770 780 790 800
SEKETELEFL KVCQRLTEYG VHFHRVHPEK KSQTGILLGV CSKGVLVFEV
810 820 830 840 850
HNGVRALVLR FPWRETKKIS FSKKKITLQN TSDGIKHAFQ TDSSKACQYL
860 870 880 890 900
LQLCSSQHKF QLQMRARQSN QDAQDLERAS FRSLNLQAES VRGFNVGRAI
910 920 930 940 950
STGSLASSTF NKLAVRPLSV QAEILKRLSC SEWSLYQPLQ NSSKEKNDKA
960 970 980 990 1000
SWEEKPRGMS KSYHDLSQAS LCPHRKQVIN MESLPQAFAE LVGKPLYPMA
1010 1020 1030 1040 1050
RSDTESLAGL PQLNNSKSVA SLNRSPERRS HESDSSVEDP GQAYVVGMSL
1060 1070 1080 1090 1100
PSSGKSSSQV PFKDNDSLHK RWSTVSSPER EITLVNLKKD LKHGLGFQIV
1110 1120 1130 1140 1150
GGGKMGRLDL GVFISAVTPG GPADLDGCLK PGDRLISVNS VSLEGVSHHA
1160 1170 1180 1190 1200
AVDILQNAPE DVTLVISQPK EKPTKVPSTP VHFANGMKNY TKKPSSMQDS
1210 1220 1230 1240 1250
AMDPSEDQPW PRGPLRHVPE SPFGLSSGLR EGSLSSQDSR TESASLSQSH
1260 1270 1280 1290 1300
VNGFFTSHLG DRGWQEPQHS SPSPPVTSKI TEKTFSDSYR SPARRQGTCD
1310 1320 1330 1340 1350
VTELPGCADS DIDDPTYSSS QDRQAPKQEP SSPLKASDKM SFAAFPGPSP
1360 1370 1380 1390 1400
EPGDAFEVEL AKTDGSLGIS VTGGVNTSVR HGGIYVKAVI PNGAAETDGR
1410 1420 1430 1440 1450
IHKGDRVLAV NGVSLEGATH KQAVETLRNT GQVVHLLLEK GQSPTSRERD
1460 1470 1480 1490 1500
PASPRCPTPD QDAQSQAPEK MEKQTAHVKD YSFVTEDNTF EVKLFKNSSG
1510 1520 1530 1540 1550
LGFSFSREDN LTPELINGSI VRVKKLFPGQ PAAESGKINV GDVILKVNGA
1560 1570 1580 1590 1600
PLKGLSQQDV ISALRGTAPE VSLLLCRPAP GVLPEVNTAL LTPLHSPAHA
1610 1620 1630 1640 1650
FLNSRKEHSQ PSPLSVEQCA SSDENGLSGQ SKRQCKPPSR RESYSDHSDS
1660 1670 1680 1690 1700
GEEESVRAAA KMPNVIPLSA FAPEALRSQG EPASTMFYLP RKIPGKPESE
1710 1720 1730 1740 1750
SSRLPHPLDV SPGQIRQPPA ECAPSDSPGK HLTHLASQLH KEENMTALKN
1760 1770 1780 1790 1800
DLGNHLEDSE LEVELLITLV KSEKGSLGFT VTKGSQSIGC YVHDVIQDPA
1810 1820 1830 1840 1850
KGDGRLRPGD RLVKVNDADV TNMTHTDAVN LLRAAPKTVR LVIGRILELP
1860 1870 1880 1890 1900
RMPVFPHLLP DITVTCHGEE LGFSLSGGRG SPHGVVYISD INPRSAAAVD
1910 1920 1930 1940 1950
CSLQLLDIIH YVNGVSTHGM TLEEANRALD LSLPSVVLKV TRDGCPVVPC
1960 1970 1980 1990 2000
STRSAISALR PLEANGLSSM EPYGQPALTP KKSFSKVNGD GASGAMCPGG
2010 2020 2030 2040 2050
KGLSSPRKKS ADLMEARESD SRDDDVYDDP QEAEVIQSLL DVVDEEAQNL
2060 2070 2080 2090 2100
LNQTKASRRA CSPDPLRTNG EASEDGEDTD CDGSPLPEDV PESVNGGGGK
2110 2120 2130 2140 2150
ACFASLIQAS QEEKPVKEEA TQESRESTTE TTDREDSSKD PLFLTNEELA
2160 2170 2180 2190 2200
ALPVVRVPPS GKYTGTQLQA TIRTLQGLLD QGIPSKELEN LQELKPLDQC
2210 2220 2230 2240 2250
LIGQTKENRR KNRYKNILPY DTTRVPLGDE GGYINASFIR IPVGTQEFVY
2260 2270 2280 2290 2300
IACQGPLPTT VGDFWQMVWE QNSTVIAMMT QEVEGEKIKC QRYWPSILGT
2310 2320 2330 2340 2350
TTMANERLRL ALLRMQQLKG FVVRVMALED IQTGEVRHIS HLNFTAWPDH
2360 2370 2380 2390 2400
DTPSHPEDLL TFISYMRHIR RSGPVITHCS AGIGRSGTLI CIDVVLGLIS
2410 2420 2430 2440 2450
QDLEFDISDL VRCMRLQRHG MVQTEGQYVF CYQVVLYVLT HLQAEEQKAQ

PGLPQ
Length:2,455
Mass (Da):270,444
Last modified:November 16, 2011 - v1
Checksum:i55B0C80CAD780D7B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07014298 Genomic DNA. No translation available.
CH474022 Genomic DNA. Translation: EDL99522.1.
RefSeqiNP_001094259.1. NM_001100789.1.
UniGeneiRn.35546.

Genome annotation databases

EnsembliENSRNOT00000061162; ENSRNOP00000057876; ENSRNOG00000002061.
ENSRNOT00000087081; ENSRNOP00000071873; ENSRNOG00000002061.
GeneIDi498331.
KEGGirno:498331.

Similar proteinsi

Entry informationi

Entry nameiG3V9S3_RAT
AccessioniPrimary (citable) accession number: G3V9S3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 22, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported